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Research Horizons at Cincinnati Children's Research Foundation

Explore highlights of the exciting research happening at Cincinnati Children's Research Foundation with Research Horizons. Each issue features recent studies published by Cincinnati Children's investigators. By combining cutting-edge research and education with the best in pediatric care, we are striving to improve the lives of children and families everywhere.This issue features these news briefs:

In addition, you will find the following feature stories that highlight some of our many world-class researchers:

The Consequences of Progress: An editorial by James Greenberg, MD, and Jeffrey Whitsett, MD, Co-directors, Perinatal Institute

James Greenberg, MD, and Jeffrey Whitsett, MD, Co-directors, Perinatal Institute.Despite advances in neonatal and perinatal medicine, certain aspects of pregnancy and parturition continue to perplex physicians and researchers. [more]

 Who's in Charge? - A new study explores whether infant or mother calls the shots before birth

Jeffrey Whitsett, MD.In a genomic-age version of the chicken-or-egg question, neonatologist and researcher Jeffrey Whitsett, MD, is pondering what leads to premature birth and influences the readiness for survival of the preterm infant. Whitsett is exploring the genes that trigger a baby’s too-early birth, how genes signals readiness for birth and who’s in control – baby or mother. [more]

Milking It: A New Line of Defense Could be as Close as Mother’s Milk

Ardythe L. Morrow, PhD.Scientists are getting closer to coming up with an immune-boosting substance that could prevent people from getting sick by studying something long known for its healing powers: breast milk. [more]

A New Way of Predicting Preemies at Risk

A New Way of Predicting Preemies at Risk.A premature baby’s saliva could hold enough clues to predict whether that infant is at risk for death, infectious diseases and necrotizing enterocolitis (NEC), the most common gastrointestinal emergency in the neonatal intensive care unit. [more]

The Facts of Life: Regional information sharing gives needed insights into prematurity

The Facts of Life: Regional information sharing gives needed insights into prematurity.Despite advances in caring for premature infants, doctors still know relatively little about what causes prematurity in the first place. Neonatologists at Cincinnati Children’s Hospital Medical Center are working with obstetricians and clinical staff at hospitals throughout Greater Cincinnati to share information that should help with that understanding. [more]

Womb With a (New) View: The ultimate source of comfort might not be what we thought

Alan Jobe, MD, PhD.The womb has long been thought of as the ultimate safe harbor – a nurturing incubator from which we’re thrust into the harsh environs of the outside world. [more]

Fetal Immune Response: A Delicate Balance

Claire Chougnet, PhD.Animal models, particularly mouse models, cannot replicate the development of the human immune system, says Claire Chougnet, PhD. The best method available for studying human immunity in its earliest stages is cord blood taken just after delivery, but that presents its own set of problems. [more]