Find a Health Care Professional / Researcher

John J. Bissler, MD

Title

Clark D. West Chair of NephrologyDirector, Nephrology Fellowship Training ProgramAssociate Program Director for Research and Academic Careers

Appointment

Associate Professor of Pediatrics

Email

john.bissler@cchmc.org

Phone

513-636-4531

Fax

513-636-7407

Credentials

MD: Northeastern Ohio University College of Medicine, Rootstown, OH, 1985.

Residency: Pediatrics, Children's Medical Center, Akron, OH.

Fellowship: Nephrology, Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1989; Pediatric Nephrology, 1992.

Awards and Honors

• Best Doctors in America, 2008
• Awarded "2005 Best Doctors"
• Awarded "2004 Best Doctors"
• Phi Beta Kappa, 1980
• Alpha Omega Alpha, 1984
• Magna cum laude Kent State University, 1985
• Outstanding Intern Award Neonatal Intensive Care, 1986
• William Cooper Procter Pediatric Research Scholar, 1991
• Trainee Investigator Award American Federation for Clinical Research, 1994

Research Grants and Contracts

DNA Structure and Mutagenesis

1. DNA Replication Fork: Pausing, Recombination and Disease
   Agency: NIH (R01 DK061458)
   PI: John J. Bissler, MD
   Dates/Effort: 5/1/03-4/30/08 (25%)
   Total Direct Costs: $1,025,002
   Goal: To investigate the contribution of alternative DNA secondary structures to replication fork arrest and induction of recombination. No overlap.

Utility of Rapamycin for the Treatment of Renal Angiomyolipomas

1. Utility of Rapamycin for the Treatment of Renal Angiomyolipomas
   Agency: NIH (R21CA103486)
   PI: John J. Bissler, MD
   Dates/Effort: 07/01/03-06/30/06 (30%)
   Total Direct Costs: $445,000
   Goal: To assess the role of rapamycin in the treatment of renal angiomyolipomas.
2. Utility of Rapamycin for the Treatment of Renal Angiomyolipomas
   Agency: TS Alliance
   PI: John Bissler, MD
   Dates/Effort: 7/1/03-6/30/06 (0%)
   Total costs: $100,000
   Goal: To assess the role of rapamycin in the treatment of renal angiomyolipomas.
3. RAD001 Therapy of Angiomyolipomata in Patients with Tuberous Sclerosis Complex and Sporadic Lymphangioleiomyomatosis
   Agency: Novartis
   PI: John Bissler, MD
   Dates/Effort: 10/1/04-9/30/06 (30%)
   Total costs: $622,248
   Goal: To assess the role of everlimus in the treatment of renal angiomyolipomata.
4. Natural History of Tuberous Sclerosis: Renal Disease
   Agency: Department of Defense
   PI: John Bissler, MD
   Dates: 06/01/05-05/31/08
   Total costs: $1,000,000
   Goal: To assess the natural history of the renal lesions in tuberous sclerosis complex.

Publications, Most Recent

• Robison JG, Lu L, Dixon K, Bissler JJ. DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci.J Biol Chem. 280:12927-12934, 2005.
• Nguyen MT, Bissler JJ. Chapter 87: Acute Renal Failure in Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. Wheeler, Wong and Shanley, Editors, 2005, Springer-Verlag: London. (In Press)
• Bissler JJ, Dixon BP. A mechanistic approach to inherited polycystic kidney disease.Pediatr Nephrol. 20:558-566, 2005.
• Williams J, Donnelly L, Johnson N, Racadio J, Bissler J. Prophylactic embolization of renal angiomyolipomas in patients with tuberous sclerosis.Journal Of Reontgenology (2005, In Press).
• VanDeVoorde, R, Bissler JJ, Section XI: Nephrology and Genitourinary Tract: Chapter 9: Hematuria and Proteinuria, in Current Pediatric Therapy, Burg FD, et al., Editors. 2005, Saunders: New York.
• Cicardi M, Bissler JJ, Sullivan KE. Swelling isn't swell.Clin Immunol. 113:231-233, 2004.
• Bissler JJ, Kingswood JC. Renal angiomyolipomata.Kidney Int. 66:924-934, 2004.
• Fricke BL, Donnelly LF, Casper KA, Bissler JJ. Frequency and imaging appearance of hepatic angiomyolipomas in pediatric and adult patients with tuberous sclerosis.AJR Am J Roentgenol. 182:1027-1030, 2004.
• Patel HP, Lu L, Blaszak RT, Bissler JJ. PKD1 intron 21: triplex DNA formation and effect on replication.Nucleic Acids Res. 32:1460-1468, 2004.
• Hopkin RJ, Bissler J, Grabowski GA. Comparative evaluation of alpha-galactosidase A infusions for treatment of Fabry disease.Genet Med. 5:144-153, 2003.
• Potaman VN, Bissler JJ, Hashem VI, Oussatcheva EA, Lu L, Shlyakhtenko LS, Lyubchenko YL, Matsuura T, Ashizawa T, Leffak M, Benham CJ, Sinden RR. Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeats.J Mol Biol. 326:1095-1111, 2003.
• Brady RC, Bissler JJ. Renal, hepatic, and marrow dysfunction in a patient with chronic renal insufficiency.Pediatr Nephrol. 18:293-296, 2003.
• Bissler JJ. Parenteral Fluid Therapy for Infants and Children. In: Rakel RE, Bope ET, eds. Conn's Current Therapy. 55th ed: W. B. Saunders Company; 2003.
• Dabora SL, Roberts P, Nieto A, Perez R, Jozwiak S, Franz D, Bissler J, Thiele EA, Sims K, Kwiatkowski DJ. Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients.Am J Hum Genet. 71:750-758, 2002.
• Casper KA, Donnelly LF, Chen B, Bissler JJ. Tuberous sclerosis complex: renal imaging findings.Radiology. 225:451-456, 2002.
• Lu L, Patel H, Bissler JJ. Optimizing DpnI digestion conditions to detect replicated DNA.Biotechniques. 33:316-318, 2002.
• Rosenberg ME, Girton R, Finkel D, Chmielewski D, Barrie A, 3rd, Witte DP, Zhu G, Bissler JJ, Harmony JA, Aronow BJ. Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging.Mol Cell Biol. 22:1893-1902, 2002.
• Bissler JJ, Racadio J, Donnelly LF, Johnson ND. Reduction of postembolization syndrome after ablation of renal angiomyolipoma.Am J Kidney Dis. 39:966-971, 2002.
• Bissler JJ, Tsoras M, Goring HH, Hug P, Chuck G, Tombragel E, McGraw C, Schlotman J, Ralston MA, Hug G. Infantile dilated X-linked cardiomyopathy, G4.5 mutations, altered lipids, and ultrastructural malformations of mitochondria in heart, liver, and skeletal muscle.Lab Invest. 82:335-344, 2002.

Professional Organization Memberships

• American Academy for the Advancement of Science, 1990
• American Society of Pediatric Nephrology, 1991
• Fellow American Academy of Pediatrics, 1992
• International Society of Pediatric Nephrology, 1996
• Molecular Medicine Society, 1996
• Physician Scientist Training Program University of Cincinnati College of Medicine, 1997
• Society for Pediatric Research, 2000
• American Society of Nephrology, 2000
• American Academy of Pediatrics Nephrology Section Member, 2000
• American Society for Biochemistry and Molecular Biology (sponsor: Robert D. Wells, PhD), 2002
• Chair-elect, Medical Board of Directors, The Kidney Foundation of Greater Cincinnati, 1999 to present
• Chairman, Patient Services Committee, The Kidney Foundation of Greater Cincinnati, 1998 to present
• Medical Board of Directors, The Kidney Foundation of Greater Cincinnati, 1996 to present

Special Interests

• Polycystic kidney disease
• Inherited renal diseases
• Disorders of complement system
• Biology of renal inflammation
• Hemodiafiltration

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center:

• University of Cincinnati Department of Pediatrics
• Nephrology and Hypertension (research)
• University of Cincinnati Department of Pediatrics (research)
• Dialysis Unit
• End-Stage Renal Disease Care Program
• Kidney Transplant Program
• Kidney Clinic
• Nephrology / Hypertension