Find a Health Care Professional / Researcher

Donald L. Gilbert, MD, MS

Title

Director, Movement Disorder Clinic and Tourette's Syndrome Clinic

Appointment

Associate Professor of Pediatric Neurology

Email

donald.gilbert@cchmc.org

Phone

513-636-4222

Fax

513-636-3980

Bio

Donald Gilbert, MD, earned his Bachelor of Arts at Princeton University, where he majored in philosophy. He subsequently earned his MD at the University of Michigan and spent a year at the National Institutes of Health as a Howard Hughes Medical Institute Research Scholar. Dr. Gilbert did his pediatrics and neurology training at Johns Hopkins in Baltimore and is board certified in neurology with special competence in child neurology. Dr. Gilbert has an MS in Clinical Research Design and Statistical Analysis from the University of Michigan.

At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette's Syndrome Clinics, which specialize in evaluation and pharmacologic treatment of tics, chorea, tremor, dystonia, stereotypies, ataxia, and other movement disorders. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette's Syndrome. Dr. Gilbert directs the Transcranial Magnetic Stimulation Laboratory at CCHMC.

Credentials

BA: Philosophy, Princeton University, Princeton, NJ, 1987

MD: Medicine, University of Michigan School of Medicine, Ann Arbor, MI, 1993

MS: Clinical Research Design and Statistical Analysis, University of Michigan, Ann Arbor, MI, 2003

Residency: Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, 1995

Fellowship: Pediatric Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 1995

Certification: Board Certified in Neurology with Special Competence in Child Neurology, 2000. Board eligible in Pediatrics.

Appointment: Associate Professor of Pediatric Neurology

Awards and Honors

1982 American Field Service Scholarship, to France
1983 Presidential Scholar
1983 High School Valedictorian
1987 Graduated Cum Laude, Princeton University
1998 Thomas Preziosi Award for Excellence in Clinical Care, Johns Hopkins
1999 Commencement Address, A.E. Stevenson High School
2000 Mead Johnson Excellence in Teaching Award
2000 NIDA/NIMH Junior Investigator Travel Award
2001 Mead Johnson Excellence in Teaching Award
2003 Mead Johnson Excellence in Teaching Award
2004 Tourette Syndrome Association Promising Young Investigator Travel Award
2006 M. Harold Fogelson MD Pediatric Neurology Teaching Award

Research

Visit Dr. Gilbert's Lab Site.

Clinical trials in Tourette's Syndrome and Associated ADHD.

Epidemiology of Tourette's Syndrome and PANDAS.

Clinical effectiveness of multi-drug treatments in Tourette's Syndrome.

Transcranial Magnetic Stimulation in Tourette's Syndrome and pediatric movement disorders.

Functional Neurosurgery for Pediatric Dystonia.

Research Grants and Contracts

Principal Investigator. Cortical Disinhibition: neurophysiological marker and endophenotype of ADHD. Translational Research Initiative, Cincinnati Children's Hospital Medical Center.

Principal Investigator: Gene Expression Profiling in Children and Adolescents with Tourette Syndrome. Funded by Tourette Syndrome Association.

Principal Investigator and Sponsor: Effects of ADHD medications on cortical excitability. Funded by Eli Lilly Company.

Principal Investigator: Effectiveness of Multi-Drug Treatments in Tourette's. National Institutes of Health K23 NS41920.

Principal Investigator: Transcranial Magnetic Stimulation Study of Tourette's Neurophysiology -- Funded by the Tourette Syndrome Association. Tourette Syndrome Association.

Site Investigator: Pandas and Strep Infection -- Are they Linked? National Institutes of Health (University of Rochester subcontract) R01 NS42240.

Site Investigator: A Prospective Longitudinal Study of Pandas. National Institutes of Health (Yale University subcontract) R01 MH61940.

Publications, Most Recent

Spencer TJ, Sallee FR, Gilbert DL, et al. Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome.J Atten Disord 2008;11:470-481.

Hershey AD, Burdine D, Liu C, Nick TG, Gilbert DL, Glauser TA. Assessing Quality and Normalization of Microarrays: Case Studies using Neurological Genomic Data.Acta Neurologica Scandinavica 2008. DOI: 10.1111 ⁄ j.1600-0404.2007.00979.x.

Giles LL, Delbello MP, Gilbert DL, Stanford KE, Shear PK, Strakowski SM. Cerebellar ataxia in youth at risk for Bipolar Disorder.Bipolar Disorders 2007. In Press.

Gilbert DL. Zhang J. Lipps TD. Natarajan N. Brandyberry J. Wang Z. Sallee FR. Wassermann EM. Atomoxetine treatment of ADHD in Tourette syndrome: reduction in motor cortex inhibition correlates with clinical improvement.Clinical Neurophysiology 2007; 118:1835-41.

Litt L, Gilbert DL, Walker W, Sharp F. Tourette Syndrome subgroups identified using blood gene expression profiling and principal components analysis.Am J Med Genetics, Part B: Neuropsychiatric Genetics. 2007; 144B:958-963.

Wu S, Graham B, Gelfand MJ, Gruppe RE, Dinopolous A, Gilbert DL. Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome.Movement Disorders 2007; 22:1813-1815.

Gilbert DL, Christian BT, Gelfand MJ, Shi B, Mantil J, Sallee FR. Altered Mesolimbocortical and Thalamic Dopamine in Tourette Syndrome.Neurology 2006; 67:1695-1697.

Gilbert DL, Wang Z, Sallee FR, Ridel KR, Merhar S, Zhang J, Lipps TD, White C, Badreldin N, Wassermann EM. Dopamine transporter genotype influences the physiological response to medication in ADHD.Brain 2006. 129:2038-2046. doi:10.1093/brain/awl147.

Gilbert DL, Ridel KR, Sallee FR, Zhang J, Lipps T, Wassermann EM. Comparison of the inhibitory and excitatory effects of ADHD medications methylphenidate and atomoxetine on motor cortex.Neuropsychopharmacology 2006; 31:442-449.

Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rašin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Šestan N, State MW. Sequence Variants in SLITRK1 are associated with Tourette's Syndrome.Science 2005; 310:317-320.

Gilbert DL, Buncher CR. Scientific and ethical issues in randomized, rater-blind, active comparator versus double-blind, placebo controlled trials in Tourette Syndrome.The Journal of Neuropsychiatry and Clinical Neurosciences 2005; 17:324-332.

Gilbert DL, Lipps TD. Tourette Syndrome.Current Treatment Options in Neurology. 2005;7:211-219.

Ridel, KR, Leslie ND, Gilbert DL. An Updated Review of the Long-term Neurological Effects of Galactosemia.Pediatric Neurology 2005;33:153-161.

Gilbert DL, Sallee FR, Zhang J, Lipps T, Wassermann EM. TMS-evoked cortical inhibition, a consistent marker of ADHD scores in Tourette Syndrome.Biological Psychiatry 2005; 57:1597-1600.

Merhar SL, Gilbert DL. Clinical (video) findings and CSF neurotransmitters in two children with severe chronic bilirubin encephalopathy, including a former-preterm infant without marked hyperbilirubinemia.Pediatrics 2005;116:1226-30.

Allen AJ, Kurlan RM, Gilbert DL, Coffey BJ, Linder SL, Lewis DW, Winner PK, Dunn DW, Dure LS, Sallee FR, Milton DR, Mintz MI, Ricardi RK, Erenberg G, Layton LL, Feldman PD, Kelsey DK, Spencer TJ. Atomoxetine Treatment in Children and Adolescents with ADHD and Comorbid Tic Disorders.Neurology 2005; 65:1941-1949.

Gilbert DL, Bansal AS, Sethuraman G, Huff T, Zhang J, Sallee FR, Wassermann EM. Association of Cortical Disinhibition with tic, ADHD, and OCD Severity in Tourette Syndrome.Movement Disorders 2004;19:416-425.

Gilbert DL, Deroos ST, Bare MA. Does Sleep or Sleep Deprivation Increase Epileptiform Discharges in Pediatric EEGs? Pediatrics 2004;114: 658-662.

Gilbert DL, Garvey M, Bansal AS, Huff T, Zhang J, Wassermann EM. Should Transcranial Magnetic Research in Children be Considered Minimal Risk?Clinical Neurophysiology 2004;18:1730-1739.

Gilbert DL, Batterson, JR, Sethuraman G, Sallee FR. Tic reduction with risperidone vs. pimozide in a randomized, double-blind, crossover trial.J Am Acad Child Adolesc Psychiatry 2004;43:206-214.

Garvey MA, Gilbert DL. Transcranial Magnetic Stimulation in Children.European Journal of Paediatric Neurology. 2004;8:7-19.

Tang Y, Schapiro M, Franz D, Patterson B, Hickey F, Schorry EK, Hopkin RJ, Wylie M, Narayan T, Glauser TA, Gilbert DL, Hershey AD, Sharp FR. Blood Expression Profiles Using Microarrays For Tuberous Sclerosis Complex 2, Neurofibromatosis type 1 and Down's Syndrome.Annals Neurology 2004;56: 808-814.

Tang Y, Hershey AD, Powers SW, Kabbouche MA, Gilbert DL, Glauser TA, Sharp FR. Genomic Abnormalities in Patients with Migraine and Chronic Migraine: Preliminary Blood Gene Expression Suggests Platelet Abnormalities.Headache 2004; 44:994-1004.

Tang Y, Glauser TA, Gilbert DL, Hershey AD, Privitera MD, Ficker DM, et al. Valproic acid blood genomic expression patterns in children with epilepsy - a pilot study.Acta Neurologica Scandinavica 2004;109(3):159-168.

Chae JH, Nahas Z, Wassermann EM, Li X, Sethuraman G, Gilbert DL, Sallee FR, George MS. A pilot safety study of repetitive transcranial magnetic stimulation (rTMS) in Tourette's syndrome. Cognitive & Behavioral Neurology 2004;17:109-17.

Tang Y, Lu A, Ran R, Aronow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR. Human blood genomics: distinct profiles for gender, age, and neurofibromatosis type 1.Molecular Brain Research 2004;132:155-167.

Gilbert DL, Dure L, Sethuraman G, Raab D, Lane J, Sallee FR. Tic reduction with pergolide in a randomized controlled trial in children.Neurology 2003;60:606-611.

Sallee FR, Gilbert DL, Vinks AA, Miceli JJ, Robarge L, Wilner K. Pharmacodynamics of ziprasidone in children and adolescents: Impact on dopamine transmission.J Am Acad Child Adolesc Psychiatry 2003;42:902-907

Gilbert DL, Sethuraman G, Kotagal U, Buncher CR. Meta-analysis of EEG test performance shows wide variation among studies.Neurology 2003;60:564-570.

Gilbert DL and Gartside P. Factors affecting the yield of pediatric EEGs in clinical practice.Clin Pediatrics 2002;41:25-32.

Gilbert DL, Sethuraman G, Sine L, Peters S, Sallee FR. Tourette Syndrome improvement with pergolide in a randomized, double-blind, crossover trial.Neurology 2000;54:1310-1315.

Gilbert DL, Buncher CR. An EEG should not be obtained routinely after first unprovoked seizure in childhood.Neurology 2000;54:635-641.

Professional Organization Memberships

Member, American Academy of Pediatrics
Member, American Academy of Neurology
Member, American Neurological Association
Member, Movement Disorder Society
Medical Advisory Board Member, Tourette Syndrome Association, 1999-present
Member, Child Neurology Society, 2000-present

Special Interests

Movement disorders; Tourette's Syndrome; Sydenham's Chorea; Kernicterus; Dystonia; Ataxia; clinical research; transcranial magnetic stimulation

Editing

Editorial Board, American Academy of Pediatrics PREP" Self-Assessment

National Medical Advisory Board, Tourette Syndrome Association

Abstracts and Presentations, Most Recent

Tic Disorders and Associated Symptoms, American Academy of Neurology Meeting, San Diego, CA, April 5, 2006.

Neurologic Disorders at the 31st Annual Review Course of the American Academy of Child and Adolescent Psychiatry, Cincinnati, OH, March 2, 2006.

Treatment of Tics, NIH symposium on Tourette Syndrome at the Child Neurology Society Meeting in Los Angeles, CA, September 28, 2005.

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections -- real or imagined and Beyond Simple Tics, American Academy of Pediatrics 2005 National Conference and Exhibition, Washington DC, October 8-11, 2005.

Clinical Research in Neurology, American Neurological Association Resident Career Day, Invited Speaker at ANA meeting, San Diego, CA, September 2005.

K23 Award Career Development Presentation, NINDS / American Neurological Association Career Development Award Meeting, Toronto, October 2, 2004

Gilbert DL, Wang Z, Ridel KR, Merhar SL, Sallee FR, Zhang J, Lipps TD, White C, Badreldin N,Wassermann EM. The effects of methylphenidate and atomoxetine on cortical inhibition in youth with ADHD differ by Dopamine Transporter Genotypes. Presented at the 58th American Academy of Neurology Annual Meeting, April 6, 2006, in San Diego, California.

Ran R, Tang Y, Du X, Franz D, Schapiro M, Gilbert D, Hershey A, Glauser T, Xu H, Lit L, Lu A, Sharp FR. Autism Related Genes Regulated in Blood of Tuberous Sclerosis Patients: Genomic Analysis Using Microarrays. Presented at the 35th Annual Meeting of the Society for Neuroscience, Washington, DC, November 12-16, 2005.

Gilbert DL, Christian BT, Gelfand MJ, Mantil J, Sallee FR: Altered Mesolimbocortical and Thalamic D2 Receptor Binding in Tourette Syndrome, a Study with [F-18]Fallypride PET, Presented at the Nineteenth Annual Symposia on Etiology, Pathogenesis, and Treatment of Parkinson's Disease and Other Movement Disorders, San Diego, CA September 25, 2005.

Gilbert DL, Leslie ND, Lipps TD, Reed L, Kretschmann K: A novel, autosomal dominant, complicated spastic paraplegia in adults with genetic anticipation and severe generalized dystonia in childhood. Presented at the 9th International Congress of the Movement Disorder Society, New Orleans, Louisiana, USA, March 6, 2005.

Gilbert DL, Ridel KR, Sallee FR, Zhang J, Lipps TD, Wassermann EM: Comparison of the inhibitory and excitatory effects of ADHD medications methylphenidate and atomoxetine on motor cortex. Presented at the 57th American Academy of Neurology Annual Meeting, Miami, FL, April 13, 2005.

Krivitzky L, Nortz M, Gilbert DL: Neuropsychological Functioning in a Case of Juvenile Parkinsonism. Presented at the 33rd Annual Meeting of the International Neuropsychology Society, St. Louis, MO, February 3, 2005.

Gilbert DL, Merhar SL, McMahon MA: Chronic Bilirubin Encephalopathy in a Premature Infant without Marked Hyperbilirubinemia. Presented at the Eighteenth Annual Symposia on Etiology, Pathogenesis, and Treatment of Parkinson's Disease and Other Movement Disorders, Toronto, CANADA, October 3, 2004.

Gilbert DL, Sallee FR, Zhang J, Lipps TD, Wassermann EM: Changes in motor cortex inhibition and ADHD symptom severity in Tourette Syndrome. Presented at the 4th International Scientific Symposium on Tourette Syndrome, Cleveland, OH USA, June 25-27, 2004.

Gilbert DL, Tang Y, Glauser TA, Hershey AD, Sharp FA: Blood Gene Expression Profiling of Tourette Syndrome -- A Pilot Microarray Study. Presented at the 4th International Scientific Symposium on Tourette Syndrome, Cleveland, OH USA June 25-27, 2004.

Wong BL, Morehart PJ, Gilbert DL: Corticosteroids, Bisphosphonates and Bone Mineral Density (BMD) in Duchenne Muscular Dystrophy. Presented at the 9th International World Muscle Society Congress, Goteborg, Sweden, Sept 1-4, 2004.

Dinopoulos A, Kure S, Chucks G, Sato K, Gilbert D, Matsubara Y, deGrauw T: Atypical Nonketotic Hyperglycinemia: 3 New Cases with GLDC Mutations. Presented at the 41st Annual Symposium of the Society for the Study of Inborn Errors of Metabolism, Amsterdam, the Netherlands, September 1-4, 2004.

Bond GR, Garro AC, Gilbert DL: Dyskinesias associated with atomoxetine in combination with other psychoactive drugs.Journal of Toxicology Clinical Toxicology 2004;42. Presented at the North American Congress of Clinical Toxicology, Seattle, Washington, September 11, 2004.

Gilbert DL, Tang Y, Glauser TA, Hershey AD, Sharp FR: Blood gene expression profiling identifies a subgroup of Tourette's syndrome patients with cytotoxic T cell involvement. Presented at the 5th Brain Research Symposium, New Orleans, LA, USA. November 6-7, 2003.

Gilbert DL, Bansal AS, Sethuraman G, Sallee FR, Zhang J, Huff T, Wassermann EM: Association of Cortical vs Behavioral Disinhibition in Tourette Syndrome and ADHD. Presented at the 32nd Annual Meeting of the Child Neurology Society, Miami FL, October 1-4, 2003.

Glauser TA, Tang Y, Gilbert DL, Hershey AD, Sharp FR. Blood Genomic Expression Patterns for Valpropic Acid Treatment and its Anticonvulsant Efficacy. Presented at the 5th Brain Research Symposium, New Orleans, LA, USA. 2003.

Gilbert DL, Franz DN, Tang Y, Lu A, Aranow B, Schorry EK, Hopkin RJ, Glauser TA, Hershey A, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR: Human Blood Genomic Profiles unique for Autosomal Dominant CNS disorders: A pilot study of Tourette Syndrome, Neurofibromatosis Type1, and Tuberous Sclerosis Type 2. Presented at the 32nd Annual Meeting of the Child Neurology Society, Miami FL, 2003.