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University of Cincinnati Department of Pediatrics

Alan H. Jobe, MD, PhD

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Alan H. Jobe, MD, PhD

Title

Director, Perinatal Biology

Appointment

Professor of Pediatrics

Email

alan.jobe@cchmc.org

Phone

513-636-8563

Fax

513-636-8691

Credentials

MD: University of California, San Diego, 1973.

PhD: Cell Biology, University of California, San Diego, CA, 1973.

Residency: Pediatrics, University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: Neonatology, University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine

Awards and Honors

  • Best Doctors in America, 2008
  • Awarded "2005 Best Doctors"
  • Awarded "2004 Best Doctors"
  • Alvo Ylppö Medal for Pediatric Research, Finnish Pediatric Societies, 2002
  • E. Mead Johnson Research Award, American Academy of Pediatrics, 1986

Research

Alan Jobe has been continuously funded since 1977 by NIH for a series of research studies focusing on surfactant, lung development and lung injury. His present research interests are to better understand the pathophysiology and treatment of bronchopulmonary dysplasia (BPD). He uses fetal sheep models of chorioamnionitis and chronic infection to explore how the fetus responds to inflammation and how that may contribute to BPD. A new direction of that research is to evaluate innate immune modulation in the fetus and its effects on postnatal immune function. Other studies are to characterize how the components of neonatal resuscitation (ventilation variables, oxygen) injure the preterm lung and how that initial injury may progress to BPD.

Research Grants and Contracts

  • NICHD - R01 Antecedents to Lung Injury in the Preterm
  • NHLBI - R01 New mediators of Clinical Lung Maturation
  • NICHD - T32 Program Director for Training Grant for Pediatric Subspecialists

Publications, Most Recent

Alan Jobe's publications as listed by PubMed

Jobe AH, Newnham JP, Moss TJ, and Ikegami M. Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep.Am. J. Ob/Gyn. 188:22-28, 2003.

Jobe AH, Scott SM, Polk DH, and Seidner SR. Adrenal and thyroid axis function in preterm ventilated baboons.Biol. Neonate. 83:208-216, 2003.

Strand M, Ikegami M, and Jobe AH. Effects of high Pco2 on ventilated preterm lamb lungs.Pediatr. Res., 53:468-472, 2003.

Smith LM, Ervin MG, Wada N, Ikegami M, and Jobe AH. Single and multiple prenatal glucocorticoid exposures improve preterm newborn lamb cardiovascular and renal function similarly.Am. J. Ob/Gyn. 188:444-453, 2003.

Kallapur SG, Jobe AH, Ikegami M, and Bachurski CJ. Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung.Am. J. Resp. Crit. Care Med. 167:779-786, 2003.

Kallapur SG, Kramer BW, Moss TJ, Newnham JP, Jobe AH, Ikegami M, and Bachurski CJ. Maternal glucocorticoids increase endotoxin induced lung inflammation in preterm lambs.Am. J. Physiol. 284:L633-L642, 2003.

Epaud R, Ikegami M, Whitsett JA, Jobe AH, Weaver TE, Akinbi HT. Surfactant protein B inhibits endotoxin-induced lung inflammation.Am. J. Respir. Cell Mol. Biol. 28:373-378, 2003.

Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, and Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants.J. Perinatol. 23:195-199, 2003.

Kramer BW, Jobe AH, and Ikegami M. Monocyte function in preterm, term and adult sheep.Pediatr. Res. 54:52-57, 2003.

Sosenko IR, and Jobe AH. Intra-amniotic endotoxin increases lung antioxidant enzyme activity in preterm lambs.Peds. Res. 53:679-683, 2003.

Ikegami M, Moss TJM., Kallapur SG, Mulrooney N, Kramer BW, Nitsos I, Bachurski CJ, Newnham, and Jobe AH. Minimal lung and systemic responses to TNF in preterm sheep.Am. J. Physiol. 285: L121-L129, 2003.

Moss TJM., Nitsos I, Newnham JP, Ikegami M, and Jobe AH. Chorioamnionitis induced by subchronic endotoxin infusion in sheep.Am. J. Ob/Gyn. Am. J. Obstet. Gynecol. 189: 1771-1776, 2003.

Moss TJM., Mulrooney N, Nitsos I, Ikegami M, Jobe AH, and Newnham JP. Intra-amniotic corticosteroids for preterm lung maturation in sheep.Am. J. Ob/Gyn. 189:1389-1395, 2003.

Newnham, JP, Kallapur SG, Kramer BW, Moss TJM., Nitsos l, Ikegami M, and Jobe AH. Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep.Am. J. Obstet. Gynecol. 189:1458-1466, 2003.

Ikegami M, Kallapur SG and Jobe AH. Responses of ventilated lambs to intra-amniotic endotoxin given 4d before preterm delivery.Am.J. Physiol. 286:L573-579, 2004.

Jobe AH and Soll RF. Choice and dose of corticosteroid for antenatal treatments.Am. J. Obstet. Gynecol. 190:878-881, 2004.

Kramer BW, Ikegami M, Moss TJM, Nitsos I, Newnham JP, and Jobe AH.
Antenatal betamethasone changes cord blood monocyte responses to endotoxin in preterm lambs.Pedaitr. Res. 55:764-768, 2004.

Mulrooney N, Jobe AH, and Ikegami M. Lung inflammatory responses to intratracheal IL-1 in ventilated preterm lambs.Pediatr. Res. 55:682-687, 2004.

Smith LM, Altamirano AK, Ervin MG, Seidner ST, and Jobe AH. Prenatal glucocorticoid exposure and postnatal adaptation in premature newborn baboons ventilated for six days.Am. J. Ob/Gyn., 191, 1688-1694, 2004.

Pillow JJ, Jobe AH, Collins RA, Hantos Z, Ikegami M, Moss TJ, Newnham JP, Willet KE, and Sly PD. Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is due to changes in surfactant pool size and histology.Am. J. Physiol Lung Cell Mol Physiol., 287:L992-L998, 2004.

Kallapur SG, Bachurski C, Le Cras TD, Joshi SN, Ikegami M, and Jobe AH. Vascular changes after intra-amniotic endotoxin in preterm lamb lungs.Am. J. Physiol Lung Cell Mol. Physiol., 287:L1178-L1185, 2004.

Kramer BW, Ikegami M, Moss TJM., Nitsos I, Newnham JP, and Jobe AH. Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep.AJRCCM, 171:73-77, 2005.

Mulrooney N, Champion Z, Moss TJM, Nitsos I, Ikegami M, and Jobe AH. Surfactant and physiological responses of preterm lambs to continuous positive airway pressure.AJRCCM, 171:1-6, 2005.

Kallapur SG, Nitsos I, Moss TJ, Kramer BW, Newnham JP, Ikegami M, and Jobe AH. Chronic endotoxin exposure does not cause structural abnormalities in the fetal sheep lungs.Am. J. Physiol. Lung Cell Mol. Physiol. Online, 2005.

Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Ch B, Wrage, LA., and Pole K. Validation of the NIH Consensus definition of bronchopulmonary dysplasia.Pediatr., In press, 2005.

Newnham JP, Shub A, Jobe AH, Bird PS, Ikegami M, Nitsos, Il, and Moss TJM. The effects of intra-amniotic administration of periodontal endotoxin in sheep.Am. J. Obstet. Gynecol. In press, 2005.

Professional Organization Memberships

  • Human Embryology and Development Study Section, 7/83-6/87
  • Chairman, Pediatrics Assembly of American Thoracic Society, 1987
  • President, Society for Pediatric Research, 1990
  • Chairman of Steering Committee for NICHD Neonatal Network, 1996-2006
  • Secretary-Treasurer, American Pediatric Society, 2003-2009
  • Member, American Board of Pediatrics - Neonatal Section, 1999; Chair, 2003-2004
  • National Advisory Child Health and Human Development Council, NIH, 2003-2007

Special Interests

  • Pulmonary biology
  • Surfactant physiology
  • Lung development

Editing

  • Associate Editor, Journal of Pediatrics, 1997 to present
  • Editorial Board, Biology of the Neonate, 1986 to present
  • Editorial Board, Journal of Applied Physiology, 1992 to 1994
  • Editorial Board, American Journal of Respiratory and Critical Care Medicine, 1993 to present
  • Editorial Board, American Journal of Physiology - Lung Cellular and Molecular Physiology, 1994 to present

Dr. Jobe speaks frequently nationally and internationally on BPD and neonatal care issues in general.

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: