University of Cincinnati Department of Pediatrics

Catherine Dent Krawczeski, MD

Title

Director, Cardiac Intensive Care; Assistant Medical Director, Cardiac Transplantation

Appointment

Associate Professor of Pediatrics

Email

catherine.krawczeski@cchmc.org

Phone

513-636-3291

Fax

513-636-3952

Credentials

MD: University of Missouri, Kansas City, Missouri, 1991.

Residency: Pediatrics, Washington University, St. Louis Children's Hospital, St. Louis, Missouri.

Fellowships: Pediatric Critical Care, Pediatric Cardiology, Washington University, St. Louis Children's Hospital, St. Louis, Missouri.

Certification:
American Board of Pediatrics 1995, recertification 2002

American Board of Pediatrics, Sub-board of Pediatric Critical Care 2000, recertification 2007

American Board of Pediatrics, Sub-board of Pediatric Cardiology 2002

Awards and Honors

American Medical Women's Association Outstanding Graduate Award, University of Missouri-Kansas City, 1991
Outstanding Student in Surgical Pathology, University of Missouri-Kansas City, 1990
Curator's Scholar, University of Missouri-Kansas City, 1985

Research

Intensive care outcomes; cardiopulmonary bypass mediated injury; neurodevelopmental outcomes in congenital heart disease; urinary biomarkers of renal ischemia

Research Grants and Contracts

Primary Investigator, American Heart Association Postdoctoral Fellowship Award, Missouri Affiliate, "Characterization of cardiac matrix remodeling and microscopic tissue material properties in diabetic cardiomyopathy," 07/01/1998- 06/30/2000.

Co-investigator, American Heart Association Grant-In-Aid, Ohio Valley Affiliate, "A novel biomarker for early ischemic renal injury," PI Prasad Devarajan, 07/01/2004-06/30/2006.

Co-investigator, National Institute of Health-NIDDK, R21, "NGAL: A novel early biomarker of acute renal injury," PI Prasad Devarajan, 9/30/2004-8/31/2006.

Co-investigator, CCHMC Translational Research Initiative, "A novel biomarker for nephrotoxic injury," PI Prasad Devarajan, 07/1/04 – 06/30/06.

Institutional Principal Investigator, National Institute of Health-NHLBI, Pediatric Heart Network, "Trial of Right Ventricular vs. Modified Blalock-Taussig Shunt in Infants with Single Ventricle Defect Undergoing Staged Reconstruction," 09/01/05-04/30/07

Co-Investigator, National Institute of Health-NHLBI, Pediatric Heart Network "Infant Single Ventricle Trial," Institutional PI: William Border, 01/01/05-03/31/07

Co-Invesigator, National Institute of Health-NHLBI, Pediatric Heart Network, Institutional PI: Woody Benson, 09/01/06-8/31/11.

Co-Investigator, CCHMC Bridge the Gap Initiative, "Proteomic analysis of urine in pathologic states", PI Prasad Devarajan, 01/01/06-12/31/07

Co-Investigator, National Institiute of Health-NHLBI, "Biomarkers of renal injury in cardiac surgery", PI Chirag Parikh, 07/01/07-06/30/12

Publications, Most Recent

Bennett M, Dent CL, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P: Urinary NGAL predicts acute kidney injury after cardiac surgery: a prospective study. Clinical Journal of the American Society of Nephrology, 2008, in press.

Portilla D, Dent C, Sugaya T, Nagothu K, Kundi I, Moore P, Noiri E, Devarajan P: Liver fatty-acid binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney International, 2007, December 19; 1-8..

Wheeler DS, Dent CL, Manning PB, Nelson DP: Factors prolonging hospital stay following the arterial switch operation. Cardiology in the Young, 2007, in press.

Dent C, Ma Q, Dastrala S, Bennett M, Mistnefes M, Barasch J, Devarajan P: Plasma NGAL predicts acute kidney injury, morbidity, and mortality after cardiac surgery: a prospective study. Critical Care Medicine, 2007 Dec 10;11(6):R127 [Epub ahead of print].

Han WK, Wailar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV: Urinary biomarkers for detection of acute kidney injury. Kidney International, 2007, Dec 5; [E pub ahead of print].

Hirsch R, Dent C, Pfriem H, Allen J, Beekman RH III, Ma Q, Dastrala S, Bennett M, Mitsnefes M, Devarajan P: NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatric Nephrology, 2007, Dec; 22 (12): 2089-2095.

Giuliano JS Jr, Sekar P, Dent CL, Border WL, Hirsch R, Manning PB, Wheeler DS: Unilateral pulmonary edema and acute rheumatic fever: Brief report and review. European Journal of Pediatrics, 2007 Apr 21; [E pub ahead of print].

Gudausky TM, Pearl J, Dent CL, Kim E, Divanovic A, Spicer RL, Beekman RH III: Open-Chest Epicardial Approach to Transcatheter Pulmonary Artery Stenting Following Heart Transplantation in an Infant.Congenital Heart Disease, 2007 Jan; 2: 64-69.

Nicolas RT, Kort HW, Balzer DT, Trinkaus K, Dent CL, Hirsch R, Canter CE: Surveillance for transplant coronary artery disease in infant, child, and adolescent heart transplant recipients: an intravascular ultrasound study.Journal of Heart and Lung Transplantation, 2006 Aug;25 (8): 921-7.

Dent CL. Cerebral Oximetry—Preventing Brain Injury after the Norwood Procedure.Neonatal Intensive Care 2006 Oct; 19(6): 45-47.

Parikh CR, Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly C, Dent C, Devarajan P and Edelstein CL: Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery.Kidney International 2006 Jul; 70 (1):199-203.

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain MRI abnormalities following the Norwood procedure using regional cerebral perfusion.Journal of Thoracic and Cardiovascular Surgery 2005 Dec; 130: 1523-30 and 2006 Jan; 131: 190-7.

Nguyen MT, Ross GF, Dent CL, Devarajan P: Early prediction of acute renal injury using urinary proteomics.American Journal of Nephrology 2005 Jul-Aug 16;25(4):318-326.

Mishra J*, Dent C*, Tarabishi R*, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch JM and Devarajan P. Neutrophil Gelatinase-Associated Lipocalin (NGAL): A novel, sensitive, specific biomarker for acute renal injury following cardiac surgery.Lancet 2005 Apr; 365:1231-38. *Co-first authors.

Schwartz SM, Dent CL, Musa NL, Nelson DP. Single Ventricle Physiology.Critical Care Clinics 2003 Jul;19: 393-411

Presentations, Most Recent

Dent CL, Nguyen M, Ross G, Harris N, Mitsnefes M, Devarajan P.: Aprotinin increases the risk of acute kidney injury following pediatric cardiac surgery. American Heart Association Scientific Sessions 2007, November 2007.

Nguyen MT, Dent CL, Ross G, Harris N, Mitsnefes M and Devarajan P.: Urinary aprotinin levels predict acute kidney injury in pediatric cardiac surgery patients. 2007 American Society of Nephrology 40th Annual Meeting & Scientific Exposition, November 2007.

Nguyen MT, Ross G, Harris N, Dent C, Mitsnefes M and Devarajan P.: Urinary aprotinin predicts acute kidney injury in pediatric cardiac surgery patients. 2007 American Society of Pediatric Nephrology Annual Meeting, April 2007.

Giuliano JS, Sekar P, Dent CL, Border WL, Hirsch R, Manning PB, Wheeler DS: Unilateral pulmonary edema and acute rheumatic fever. 36th Critical Care Congress, Society of Critical Care Medicine, February 2007.

Brilli R, Dent C, Fridriksson J, Shaw J, Boundarant P, Ryckman S, Wells D, Raake J, Amato R, Schwartz S.: Pediatric VAP bundle reduces VAP in PICU, NICU, CICU. 36th Critical Care Congress, Society of Critical Care Medicine, February 2007.

Dent CL, Beebe DW, Spaeth JP, Jones BV, Barnard T, Bogenschutz T, Kurth CD: Gross motor delay is common early after the Norwood procedure even in the presence of a normal brain MRI. American Heart Association Scientific Sessions 2006, November 2006.

Hirsch R, Dent C, Pfriem H, Allen J, Mishra J, Ma Q, Kelly C, Beekman R, Mitsnefes M, Devarajan P: NGAL is an early predictive biomarker of acute kidney injury following cardiac catheterization with contrast administration in children. American Heart Association Scientific Sessions 2006, November 2006.

Devarajan P, Hirsch R, Dent C, Pfriem H, Allen J, Beekman R, Mishra J, Ma Q, Kelly C, Mitsnefes M: NGAL is an early predictive biomarker of acute kidney injury following contrast administration. American Society of Nephrology 39th Annual Meeting & Scientific Exposition, October 2006.

Vandevoorde R, Kathman T, Dent C, Devarajan P: Serum Cystatin C is a novel predictive biomarker for acute kidney injury. 2006 Pediatric Academic Societies' Annual Meeting, April 2006.

Nguyen MT, Ross G, Harris N, Kathman T, Dent C, Devarajan P: Characterization of a novel biomarker panel for acute kidney injury. 2006 Pediatric Academic Societies' Annual Meeting, April 2006.

Willis M, Alfaro MP, Byrge M, Barlow C, Jones K, Lingsch T, Border W, Manning P, Dent C: The evolution of a postcardiothoracic surgery feeding guideline: evidence-based practice. Ninth Annual Update on Pediatric Cardiovascular Disease, February 2006.

Sajan I, Dent C, Schwartz S, Wedekind C, Bogenschutz L, VanVliet T, Nelson D: Adrenal dysfunction contributes to catecholamine refractory low cardiac output syndrome in critically ill children. American Heart Association 2005 Scientific Sessions, November 2005.

Spaeth JP, Dent CL, Jones BV, Kurth CD: Preoperative cerebral oximetry, cerebral activity and MRI findings in neonates with HLHS before surgical palliation. American Society of Anesthesiologists Annual Meeting 2005, October 2005.

Spaeth JP, Dent CL, Jones BV, Kurth CD: Postoperative cerebral oximetry and MRI findings in neonates with HLHS following stage I palliation. American Society of Anesthesiologists Annual Meeting 2005, October 2005.

Sajan I, Dent C, Schwartz S, Wedekind C, Bogenschutz L, VanVliet T, Nelson D: Adrenal dysfunction in critically ill children with congenital heart disease. ODICH 2005, May 2005.

Dent CL, Tarabishi R, Mishra J, Ma Q, VanVliet T, Bogenschutz L, Mitsnefes M, Devarajan P: NGAL: A novel early biomarker of renal injury following cardiac surgery. American College of Cardiology Annual Sessions 2005, March 2005.

Spaeth JP, Dent CL: Anesthetic management for MRI scanning in neonates with hypoplastic left heart syndrome. Society of Pediatric Anesthesia Annual Meeting, February 2005.

Spaeth JP, Dent CL, Jones BV, Kurth CD. MRI findings in neonates with HLHS undergoing the Norwood procedure using regional cerebral perfusion. Society of Pediatric Anesthesia Annual Meeting, February 2005.

Sajan, I, Dent C, Schwartz S, Wedekind C, Bogenschutz L, VanVliet T, Nelson D: Relative adrenal insufficiency in children with congenital heart disease. 34th Critical Care Congress, Society of Critical Care Medicine, January 2005.

Sajan, I, Dent C, Schwartz S, Wedekind C, Bogenschutz L, VanVliet T, Nelson D: Relative adrenal insufficiency in children following congenital heart surgery. PCICS 5th International Symposium on Pediatric Cardiac Intensive Care, December 2004.

Dent CL, Spaeth JP, Schwartz SM, Jones BV, VanVliet T, Bogenschutz L, Hallinan B, Glauser TA, Kurth CD: Characterization of MRI abnormalities before and after Norwood palliation for hypoplastic left heart syndrome. American Heart Association 2004 Scientific Sessions, November 2004.

Dent CL, Schwartz SM, Spaeth JP, Bogenschutz L, VanVliet T, Nelson DP, Pearl JM, Kurth CD: Impaired cerebral oxygenation is common in the perioperative Norwood period. American Heart Association 2004 Scientific Sessions, November 2004.

Nicolas RT, Kort HW, Balzer DT, Trinkaus K, Dent CL, Hirsch R, Canter CE: Recipient and donor age affect the development of coronary arteriopathy after pediatric cardiac transplantation: An intravascular ultrasound study. American Heart Association 2004 Scientific Sessions, November 2004.

Devarajan P, Tarabishi R, Mishra J, Ma Q, Mitsnefes M, Dent C: NGAL: A novel early biomarker of renal injury following cardiac surgery. American Society of Nephrology 37th Annual Meeting & Scientific Exposition, October 2004.

Markham L, Shanley T, Spicer R, Dent C, Schwartz S, Wong B, Cripe L: The use of combined cardiopulmonary therapy for symptomatic heart failure associated with Duchenne muscular dystrophy. World Muscle Society Meeting, September 2004.

Wheeler DS, Pearl JM, Schwartz SM, Dent C, Manning PB, Nelson DP: Factors prolonging ICU stay following the arterial switch operation (ASO) for transposition of the great arteries (TGA). 33rd Critical Care Congress, Society of Critical Care Medicine, February 2004.

Musa NL, Dent CL, Nelson DP, Manning PB, Pearl JM, Schwartz SM: Blood pressure is inversely related to oxygen delivery early after Norwood operation. 33rd Critical Care Congress, Society of Critical Care Medicine, February 2004.