David I. Bernstein, MD, MA
Title
Director, Infectious Diseases; Director, Gamble Program
Appointment
Albert Sabin Professor of Pediatrics
Email
david.bernstein@cchmc.org
Phone
513-636-7625
Fax
513-636-7682
Bio
Dr. Bernstein received his MA degree in microbiology and his MD degree from SUNY at Buffalo. His pediatric training was undertaken at USC and the New England Medical Center. This was followed by an ID fellowship at UCLA. During his fellowship he became interested in herpes viruses and vaccines. Upon arrival at Cincinnati Children’s Hospital Medical Center he began his work investigating the immunobiology of genital herpes infections. At this time he also became interested in rotavirus and along with his colleague Dr. Richard Ward he investigated the immune responses that provide protection. This work led to the development of a live attenuated human rotavirus vaccine initially named 89-12. The 89-12 vaccine was further modified and became the GlaxoSmithKline rotavirus vaccine, Rotarix, currently available in over 100 countries including the USA and EU. Dr. Bernstein is currently evaluating vaccines for CMV, HSV, influenza, avian influenza, RSV, norovirus and parvovirus. Dr. Bernstein has published over 200 manuscripts and book chapters on infectious diseases, vaccines and antivirals. Dr. Bernstein is currently the Albert Sabin Professor of pediatrics and director of the Division of Infectious Diseases at Cincinnati Children’s and directs one of eight NIH funded Vaccine Evaluation Units.
Credentials
MA: Microbiology, State University of New York at Buffalo, Buffalo, NY, 1973.
MD: State University of New York at Buffalo School of Medicine, Buffalo, NY, 1977.
Residency: Pediatrics, University of Southern California Medical Center, Los Angeles, CA; Tufts University School of Medicine, Boston, MA.
Fellowship: Pediatric Infectious Disease, University of California, Los Angeles, CA.
Certification: American Board of Medical Examiners, 1978; American Board of Pediatrics, 1981; Pediatrics, 1982.
Awards and Honors
Best Doctors in America, 2008
Research
Dr. Bernstein has been interested in the development and evaluation of vaccines and antivirals for many common viral infections. His work ranges from the basic understanding of the pathogenesis and immunobiology of herpes viruses and rotavirus to evaluation of vaccines and antivirals for these diseases. His work frequently takes him from preclinical evaluations in animal models to human trials. Dr. Bernstein’s interest include the development of improved adjuvants and delivery systems for vaccines. His most important accomplishment was the development and early evaluation of a live oral rotavirus vaccine that became the GlaxoSmithKline rotavirus vaccine, Rotarix, now available in over 100 countries. Dr Bernstein is also a part of programs dedicated to the treatment and prevention of influenza, norovirus and parvovirus infections.
Research Grants and Contracts
Development of strategies to treat and prevent Norovirus infections, 2004-2008, Co-Investigator.
HHSN260200500008C, The natural history of CMV-related hearing loss and the feasibility of CMV screening as adjunct to hearing in the newborn, 2005-2012, Co-Investigator and Principal Investigator of Cincinnati site.
NO1-AI-80006, Vaccine and Treatment Evaluation Units (VTEUs): Evaluation of Control Measures Against Diseases Other Than AIDS, 2007-2014, Prinicpal Investigator.
Presentations
Bernstein, D.I., Bravo, F.J., Cardin, R.D. Cyclic HPMPC therapy improves the outcome of guinea pig cytomegalovirus infection and decreases the viral load in the placenta and fetus. The 18th International Conference on Antiviral Research, Barcelona, Spain, April 2005.
Bernstein, D.I., Bravo, F.J., Cardin, R.D. Effect of cyclic HPMPC on viral replication and the outcome of guinea pig cytomegalovirus congenital infection. Pediatric Academic Society, Washington, D.C., May 2005.
Kahn, J.A., Zimet, G.D., Bernstein, D.I., Lan, D., Huant, B., Riedesel, J.M., Rosenthal, S.L. Pediatrician’s intention to recommend HPV vaccine. Pediatric Academic Society, Washington, D.C., May 2005.
Ireland, J.E., Guzman, E., Vaillant, A., Juteau, J-M, Cardin, R., Herold, B.C., Bernstein, D.I. Potent antiviral activity of REP 9 and analogs against HSV-2 infection. 19th International Conference on Antiviral Research, San Juan, Puerto Rico, May 2006.
Bernstein, D.I. Future vaccines for adolescents. 9th Annual Conference on Vaccine Research, Baltimore, MD, May 2006.
Nolan, T., Bernstein, D.I., Block, S., Hilty, M., Keyserling, H., Marchant, C., Yogev, R., Cho, P., Mendelman, P. Safety and immunogenicity of concurrent LAIV (FluMistÒ) with measles-mumps-rubella (MMRÒII) and Varicella (VarivaxÒ) vaccines in infants 12 to 15 months of age. Pediatric Academic Society, San Francisco, CA, May 2006.
Strasser, J., Cardin, R., Chalk, C., Ireland, J., Fairman, J., Bernstein D. JuvImmune is a novel vaccine adjuvant that enhances protection of mice from lethal HSV-2 infection hollowing immunization. 20th International Conference on Antiviral Research, Palm Springs, CA, May 2007.
Bravo, F., Cardin, R., Bernstein, D. An animal model of HCMV infection in SCID mice. 20th International Conference on Antiviral Research, Palm Springs, CA, May 2007.
Bravo, F.J., Cardin, R.C., Hostetler, K.Y. and Bernstein, D.I. Effect of treatment with the cidofovir analogue HDP-CDV in guinea pig models of congenital cytomegalovirus infection. Pediatric Academic Society, Honolulu, HI, May 2008.
Publications, Most Recent
Bravo, F.J., Cardin, R.D. and Bernstein, D.I. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J. Infect Dis. 193:591-597, 2006.
Bernstein, D.I. and Ward, R.L. Rotarix: Development of a live attenuated monovalent human rotavirus vaccine.Pediatric Annals. 35:38-43, 2006.
Heineman, T.C., Schleiss, M., Bernstein, D.I., Spaete, R.R., Yan, L., Duke, G., Prichard, M., Wang, Z., Yan, Q. Sharp, M.A., Arvin, A.M. and Kemble, G. A phase 1 study of four live, recombinant HCMV Towne/Toledo chimeric vaccines.J. Infect. Dis. 193:1350-1360, 2006.
Madhi, S.A., Cutland, C., Zhu, Y., Hackell, J.G., Newman, F., Blackburn, N., Murphy, B.R., Belshe, R.B., Karron, R.A., Deatly, A.M., Gruber, W.C., Bernstein, D.I., Wright, P.F. Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers.Vaccine. 20:2432-2439, 2006.
Ward, J.I., Cherry, J.D., Chang, S.J., Partridge, S., Keitel, W., Edwards, K., Lee, M., Treanor, J., Greenberg, D.P., Barenkamp, S., Bernstein, D.I., Edelman, R.; APERT Study Group. Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT).Clin. Infect. Dis. 43:151-157, 2006.
Rosenthal, S.L., Zimet, G.D., Leichliter, J.S., Stanberry, L.R., Fife, K.H., Tu, W., Bernstein, D.I. The psychosocial impact of serological diagnosis of asymptomatic herpes simplex virus type 2 infection.Sex. Transm. Infect. 82:154-157, 2006.
Staat, M.A., Cortese, M.M., Bresee, J.S., Begue, R.E., Vitek, C., Rhodes, P., Zhang, R., Gentsch, J., Roberts, N.E., Jaeger, J.L., Ward, R., Bernstein, D.I., Dennehy, P.H. Rhesus rotavirus vaccine effectiveness and factors associated with receipt of vaccine.Pediatr Infect Dis J. 25:1013-1018, 2006.
Bernstein, D.I. Live attenuated human rotavirus vaccine, Rotarix.Semin Pediatr Infect Dis. 17:188-194, 2006.
Klein, N.P., Holmes, T.H., Sharp, M.A., Heineman, T.C., Schleiss, M.R., Bernstein, D.I., Kemble, G., Arvin, A.M., Dekker, C.L. Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults.Vaccine. 24:5913-5918, 2006.
Ward, R.L., Kirkwood, C.D., Sander, S., Smith, V.E., Shao, M., Bean, J.A., Sack, D.A., and Bernstein, D.I. Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate.J. Infect. Dis. 194:1729-1736, 2006.
Bravo, F.J., Cardin, R.D., Bernstein, D.I. A model of human cytomegalovirus infection in severe combined immunodeficient mice.Antiviral Res. 76:104-110, 2007.
Kahn, J.A., Rosenthal, S.L., Tissot, A.M., Bernstein, D.I., Wetzel, C., Zimet, G.D. Factors influencing pediatricians’ intention to recommend human papillomavirus vaccines.Ambul. Pediatr. 7:367-373, 2007.
Professional Organization Memberships
Infectious Disease Society of America
Society for Pediatric Research
Pediatric Infectious Disease Society
American Society for Microbiology
American Society for Virology
International Society for Antiviral Research
- American Pediatric Society
Special Interests
Rotavirus; herpes simplex virus; cytomegalovirus; preclinical and clinical evaluations of vaccine; immune respose to herpes virus
Patents
Editorial Boards
Antiviral Research 1996 - Present
Antimicrobial Agents and Chemotherapy 2002 – Present
Board of Directors
Elected Position, Board of Directors, Society for Antiviral Research 2000 - Present
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
