James E. Heubi, MD
Title
Director, General Clinical Research Center
Appointment
Professor of Pediatrics
Email
james.heubi@cchmc.org
Phone
513-636-4415
Fax
513-636-4695
Bio
James E. Heubi, MD, has been a practicing pediatric gastroenterologist since 1979, when he joined the staff at Cincinnati Children's Hospital Medical Center.
Dr. Heubi's practice includes the treatment of all disorders affecting the gastrointestinal tract, liver and biliary tract and pancreas.
Dr. Heubi's areas of practice interests include liver disease and complications related to end-stage liver disease and liver transplantation and the management of patients with "short gut" or compromised gut function requiring prolonged enteral or parenteral nutritional support.
Dr. Heubi is the Director of General Clinical Research Center at Cincinnati Children's and is the Associate Dean for Clinical Research, University of Cincinnati, College of Medicine.
Credentials
MD: Indiana University School of Medicine, Indianapolis, IN, 1973.
Residency: Pediatric Residency, James Whitcomb Riley Hospital for Children, Indiana University, Indianapolis, IN, 1973 to 1975.
Fellowship: Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati, OH, 1975 to 1978.
Certification: Pediatric Gastroenterology and Nutrition, 1990.
Awards and Honors
Research
- Cholesterol absorption
- Cholesterol metabolism
- Inborn errors of bile acid metabolism
- Bone metabolism in health and disease
- TPN-related cholestestasis and its treatment
Research Grants and Contracts
MO1 RR08084 (PI: Boat / PD: Heubi)
12/01/01 to 11/30/06
NIH / NCRR
General Clinical Research Center
R01 DK68463 (Heubi)
5/1/05-1/31/10
NIH/NIDDK
Intralumenal Effects on Cholesterol Absorption/Synthesis
R01 AT2190 (Setchell)
9/22/05-9/21/09
NIH/NCCAM
Soy Isoflavone Metabolite Equol-Formation and Fate
U54 RR019455 (PD: Sokol/Center PI: Heubi)
6/01/04 to 5/31/09
NIH / NCRR
Rare Liver Disease Network
N01-HD-1-3329 (Kalkwarf PI)
8/1/06-7/31/09
NIH
Bone Mineral Density in Childhood Study: Clinical Center
NIH P20 RR 023846 (Tsevat PI)
09/01/2006-08/31/2007
NIH/NCRR (Role Co-Investigator)
University of Cincinnati CTSA Planning Grant
Cystic Fibrosis Foundation (Heubi)
1/01/06-12/31/06
Fecal Behenic Acid: A New Marker for Fat Malabsorption
T35 (Heubi)
4/1/02 to 3/31/07
NIH (NIDDK)
Short-Term Medical Student Training Grant
T32 DK07727 (Cohen PI)
7/01/05 to 6/30/10
NIH / NIDDK
Pediatric Gastroenterology and Nutrition Training Grant
Children's Hospital Research Foundation 10/1/02 to 9/30/03 (Heubi PI)
Intravenous Sulfates of Ursodeoxycholic Acid for Prevention / Treatment of TPN-Associated Liver Disease
Publications, Most Recent
View James Heubi's publications at Cincinnati Children's as listed by PubMed.
- Jandacek RJ, Heubi JE, Tso P. (2004) A novel, noninvasive method for the measurement of intestinal fat absorption.Gastroenterology 127:139-44.
- Bove KE, Heubi JE, Balistreri WF, Setchell KD. (2004) Bile acid synthetic defects and liver disease: a comprehensive review.Pediatr Dev Pathol 7:315-34.
- Guthery SL, Heubi JE, Filipovich A. (2004) Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study.Bone Marrow Transplant 33:1235-9.
- Miles L, Heubi JE, Bove KE. (2005) Hepatocyte glycogen accumulation in patients undergoing dietary management of urea cycle defects mimics storage disease.J Pediatr Gastroenterol Nutr 40:471-6.
- Stark LJ, Hommel KA, Mackner LM, Janicke DM, Davis AM, Pfefferkorn M, Crandall W, Heubi J. (2005) Randomized trial comparing two methods of increasing dietary calcium intake in children with inflammatory bowel disease.J Pediatr Gastroenterol Nutr 40:501-7.
- Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. (2005) Liver transplantation in children younger than 1 year--the Cincinnati experience.J Pediatr Surg 40:268-73.
- Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. (2005) Liver transplantation in children younger than 1 year–the Cincinnati experience.J Pediatr Surg 40:268-73; discussion 273.
- Demmers TA, Jones PJ, Wang Y, Krug S, Creutzinger V, Heubi JE. (2005) Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age.Pediatrics 115:1594-601.
- Setchell KD, Clerici C, Lephart ED, Cole SJ, Heenan C, Castellani D, Wolfe BE, Nechemias-Zimmer L, Brown NM, Lund TD, Handa RJ, Heubi JE. (2005) S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.Am J Clin Nutr 81:1072-9.
- Borowitz D, Durie PR, Clarke LL, Werlin SL, Taylor CJ, Semler J, De Lisle RC, Lewindon P, Lichtman SM, Sinaasappel M, Baker RD, Baker SS, Verkade HJ, Lowe ME, Stallings VA, Janghorbani M, Butler R, Heubi J. (2005) Gastrointestinal outcomes and confounders in cystic fibrosis.J Pediatr Gastroenterol Nutr 41:273-85.
- Thomas SR, Kalkwarf HJ, Buckley DD, Heubi JE. (2005) Effective dose of dual-energy X-ray absorptiometry scans in children as a function of age.J Clin Densitom 8:415-22.
- Stark LJ, Davis AM, Janicke DM, Mackner LM, Hommel KA, Bean JA, Lovell D, Heubi JE, Kalkwarf HJ. (2006) A randomized clinical trial of dietary calcium to improve bone accretion in children with juvenile rheumatoid arthritis.J Pediatr 148:501-7.
- Focht DR, 3rd, Baker RC, Heubi JE, Moyer MS. (2006) Variability in the management of childhood constipation.Clin Pediatr (Phila) 45:251-6.
- Woollett LA, Wang Y, Buckley DD, Yao L, Chin S, Granholm N, Jones PJ, Setchell KD, Tso P, Heubi JE. (2006) Micellar solubilisation of cholesterol is essential for absorption in humans.Gut 55:197-204.
- Setchell KD, Heubi JE. (2006) Defects in Bile Acid Biosynthesis-Diagnosis and Treatment.J Pediatr Gastroenterol Nutr 43:S17-S22.
Special Interests
Additional Appointments:
Associate Dean for Clinical Research, University of Cincinnati College of Medicine
Program Director, Medical Student Summer Research (funded by National Institutes of Health T35 DK060444), University of Cincinnati College of Medicine
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
