University of Cincinnati Department of Pediatrics

Prasad Devarajan, MD

Title

Louise M. Williams Endowed Chair, Director of Nephrology and Hypertension

Appointment

Professor of Pediatrics and Developmental Biology, University of Cincinnati College of Medicine

Email

prasad.devarajan@cchmc.org

Phone

513-636-4531

Fax

513-636-7407

Credentials

Premedical Studies: Bombay University, India, 1979

MD: Bombay University, India, 1985

Position History

1985-1986 Graduate Research, Dept of Physiology (Laboratory of Leon C. Moore, Ph.D.), SUNY Stony Brook, NY

1986-1989 Internship and Residency, Dept of Pediatrics, SUNY Stony Brook, NY

1989-1991 NIH Fellow, Pediatric Scientist Development Program, Hematology / Genetics, (Laboratory of Edward J. Benz, Jr., MD), Yale University School of Medicine, New Haven, Conn.

1991-1993 Postdoctoral Fellowship, Dept. of Pediatrics, Division of Nephrology, Yale University School of Medicine, New Haven, Conn.

1993-1995 Research Associate, Dept of Pathology and Cell Biology (Laboratory of Jon S. Morrow, MD, PhD), Yale University School of Medicine, New Haven, Conn.

1993-1998 Assistant Professor, Dept of Pediatrics, Division of Nephrology, Yale University School of Medicine, New Haven, Conn.

1998-2002 Associate Professor and Director of Research, Dept. of Pediatrics, Division of Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY

July 2002 Louise M. Williams Endowed Chair, Professor of Pediatrics and Developmental Biology, Director of Nephrology and Hypertension, Director of Clinical Nephrology Laboratories, CEO of the Dialysis Unit, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

Awards and Honors

Best Doctors in America, 2008

Awarded "2005 Best Doctors"

1992-present Member, Society for Pediatric Research, American Society of Pediatric Nephrology, International Pediatric Nephrology Association, American Society of Nephrology, National Kidney Foundation, American Heart Association

2000-present Reviewer, multiple NIH Study Sections and Special Emphasis Panels

2001-present Member, American Society of Pediatric Nephrology Research Council

2001-present Associate Editor, American Journal of Physiology (Cell Physiology)

2001-present Associate Editor, Pediatric Nephrology

2001-present Managing Editor, Frontiers in Bioscience

2001-present Editorial Board, Cancer Therapy

2004-present ASPN representative, Acute Kidney Injury Network

2005-2008 Acute Renal Failure Advisory Committee, American Society of Nephrology

2008-present American Society of Pediatric Nephrology Program Committee

2008-present Elected Council Member, American Society of Pediatric Nephrology

Research Grants and Contracts

NIH/NIDDK R01 Devarajan (PI) 04/01/05-03/31/10
Implications of the ASK1/JNK pathway in ARF 1.2 calendar months
This proposal examines the role of ASK1/JNK signal transduction pathway in acute renal failure

Department of Defense Devarajan (PI) 07/01/07-06/30/10
Early Prediction of Lupus Nephritis Using Advanced Proteomics 1.2 calendar months
The proposal seeks to identify differentially expressed urinary proteins in lupus, using proteomic profiling

NIH/NIDDK T32 Devarajan (PI) 07/01/07-06/30/12
Research Training in Pediatric Nephrology 0.6 calendar months
This is the Training Grant for the Pediatric Nephrology Fellowship

NIH/NHLBI R01 Parikh (PI); Devarajan (Center PI) 07/01/07-06/30/12
Biomarkers of renal injury in cardiac surgery 1.2 calendar months
This proposal seeks to validate NGAL, cystatin C and IL-18 as biomarkers of renal injury after cardiac surgery

NIH/NIDDK U01 Parikh (PI); Devarajan (Center PI) 09/01/08-08/30/13
Long term outcomes of AKI after cardiac surgery 0.6 calendar months
This proposal seeks to define the long term outcomes of acute renal injury after cardiac surgery

CCHMC Translational Research Initiative Devarajan (PI) 07/01/09-06/30/10
Novel biomarkers for lupus renal disease 0.6 calendar months
This proposal seeks to validate novel urinary biomarkers in patients with lupus nephritis

Publications, Most Recent

Prasad Devarajan's publications as listed by PubMed

Haase M, Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Reade MC, Bagshaw SM, Seevanayagam N, Seevanayagam S, Doolan L, Buxton B, Dragun D. Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med. 2009 Jan;37(1):39-47

Suzuki M, Wiers K, Brooks EB, Greis KD, Haines K, Klein-Gitelman MS, Olson J, Onel K, O'Neil KM, Silverman ED, Tucker L, Ying J, Devarajan P, Brunner HI. Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis.Pediatr Res. 2009 May;65(5):530-6

Bennett MR, Ravipati N, Ross G, Nguyen MT, Hirsch R, Beekman RH, Rovner L, Devarajan P. Using proteomics to identify preprocedural risk factors for contrast induced nephropathy. Proteomics Clin Appl. 2008;2(7-8):1058-1064.

Devarajan P. Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant. 2008 Dec;23(12):3737-43

Stabach PR, Devarajan P, Stankewich MC, Bannykh S, Morrow JS. Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells. Am J Physiol Cell Physiol. 2008 Nov;295(5):C1202-14

Devarajan P. NGAL in acute kidney injury: from serendipity to utility. Am J Kidney Dis. 2008 Sep;52(3):395-9

Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, Buchen C, Khan F, Mori K, Giglio J, Devarajan P, Barasch J. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med. 2008 Jun 3;148(11):810-9

NguyenMT, Dent CL, Ross GF, Harris N, Manning PB, Mitsnefes MM, Devarajan P. Urinary aprotinin as a predictor of acute kidney injury after cardiac surgery in children receiving aprotinin therapy. Pediatr Nephrol. 2008 Aug;23(8):1317-26

Lewis AG, Köhl G, Ma Q, Devarajan P, Köhl J. Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival. Clin Exp Immunol. 2008 Jul;153(1):117-26

Ma Q, Devarajan P. Induction of proapoptotic Daxx following ischemic acute kidney injury. Kidney Int. 2008 Aug;74(3):310-8

Bennett M, Dent CL, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol. 2008 May;3(3):665-73

Devarajan P, Parikh C, Barasch J. Case 31-2007: a man with abdominal pain and elevated creatinine. N Engl J Med. 2008 Jan 17;358(3):312

Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006 Jun;17(6):1503-20.

Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D'Agati V, Devarajan P, Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest. 2005 Mar;115(3):610-21.

Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005 Apr 2-8;365(9466):1231-8