Suhas G. Kallapur, MD
Appointment
Associate Professor of Pediatrics, University of Cincinnati College of Medicine
Email
suhas.kallapur@cchmc.org
Phone
513-636-3879
Fax
513-636-7868
Credentials
MBBS: University of Bombay, India, 1984.
DCH: College of Physicians and Surgeons, Bombay, 1986
MD, Pediatrics: University of Bombay, India, 1986
Residency: Pediatrics, University of Bombay, India, 1984-87
Residency: Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, 1988-90.
Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1990-1993.
Position History
Associate Professor of Pediatrics, Children’s Hosp. Med. Center, Cincinnati, OH, 2004-present
Assistant Professor of Pediatrics, Children’s Hosp. Med. Center, Cincinnati, OH, 1997-2004
Staff Pediatrician, Children’s Hosp. Med. Center, Cincinnati, OH, 1995-1996
Instructor in Pediatrics, Univ. of Cincinnati, Cincinnati, OH, 1993-1996
Fellow, Neonatal-Perinatal Medicine, Children’s Hosp. Med. Center, Univ. of Cincinnati, Cincinnati, OH, 1990-1993
Resident in Pediatrics, Children’s Hospital of Michigan, Wayne State Univ., Detroit MI, 1989-1990
Intern, Pediatrics, Children’s Hospital of Michigan, Wayne State Univ., Detroit, MI, 1988-1989
Residency in Pediatrics, Seth GS Medical College, KEM, Hospital & B.J. Wadia; Hospital for Children, University of Bombay, Bombay, India, 1984-1987
Awards and Honors
Director of CME, Division of Neonatology, Cincinnati, 2004-present
William Cooper Procter Scholarship for Post Fellowship Training in Basic Science and Molecular Genetics, 1993-1995
Best Resident for 1989 - 1990 at the Children's Hospital of Michigan, Detroit, Michigan, USA
Adjudged the Best Resident for 1987 at the K.E.M. Hospital, Bombay, India
Research
Our group is interested in understanding how the fetus copes with and adapts to infectious and inflammatory insults in utero e.g. exposure to chorioamnionitis. Our research focus is to understand the pathogenesis of lung injury, and systemic inflammatory responses in fetuses and newborns. We use sheep model and have begun some work in humans.
Research Grants and Contracts
Active
NIH-NICHD - R01 HD57869: Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis. (PI) 02/03/09-01/31/14
NIH-NICHD 5 R01 HD12714-29: Neonatal Resuscitation and Preterm Lung Injury. (Co-Investigator; PI Jobe) 12/01/05-11/30/10
Completed
MERCK (MSG ID#28268): Pharmacokinetics of Montelukast in very low birth weight (VLBW) infants. (PI) 12/1/06-11/30/08
Publications, Most Recent
Kallapur SG, Moss TJM, Auten RL, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intraamniotic LPS induced inflammation and maturation in preterm fetal lamb lung. Submitted 2009.
Kramer BW, Moss TJM, Nitsos I, Polglase G, Newnham JP, Kallapur SG, Jobe AH. Modulation of systemic inflammatory responses by chorioamnion, lung or gut exposures to LPS in the fetal sheep. Submitted 2009.
Hillman NH, Kallapur SG, Pillow JJ, Moss TJM,Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Submitted 2009.
Jobe AH, Pillow JJ, Nitsos I, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Submitted 2009.
Kallapur SG, Nitsos I, Moss TJM, Polglase GR, Pillow JJ, Cheah FC, Kramer BW, Newnham JP, Ikegami M, Jobe AH. IL-1 signaling mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by intra-amniotic LPS.Am J Respir Crit Care Med 2009 (In press).
Cheah FC, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intraamniotic lipopolysaccharide in a sheep model of chorioamnionitis.Am J Physiol Lung Mol Cell Biol 2009;296:L384-93.
Pillow JJ, Hillman NH, Polglase GR, Moss TJM, Champion Z, Kallapur SG, Cheah FC, Kramer BW, Jobe AH. Oxygen, temperature and humidity content of inspired gases and their influences on lung injury in near-term lambs. Submitted 2009.
Ball MK, Jobe AH, Polglase GR, Kallapur SG, Cheah FC, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs.Resuscitation 2009 (In press).
Kramer BW, Kallapur SG, Moss TJM, Nitsos I, Newnham JP, Jobe AH. Intraamniotic LPS modulates TLR signaling in the lung and blood monocytes of fetal sheep.Innate Immunity 2009 (In press).
Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and Systemic Inflammation in Preterm Lambs on CPAP or Conventional Ventilation.Pediatr Res 2009 (In press).
Moss TJM, Nitsos I, Knox CL, Polglase G, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.Am J Obstet Gynecol 2009;200:96e1-e6.
Polglase GR, Hillman N, Pillow JJ, Cheah FC, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive End-Expiratory Pressure and Tidal Volume During Initial Ventilation of Preterm Lambs.Pediatric Research 2008;64:517-22.
Sweet DG, Huggett MT, Warner JA, Moss TJM, Kloosterboer N, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal Betamethasone and Chorioamnionitis Induce Different Collagenases during Lung Maturation in Fetal Sheep.Neonatology 2008;94:79-86.
Hillman NH, Moss TJM,Kramer BW, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Toll-Like Receptors and Agonist Responses in the Developing Fetal Sheep Lung.Pediatr Res 2008;63:388-93.
Cheah FC, Jobe AH, Moss TJM, Newnham JP, Kallapur SG. Oxidative stress infetal lambs exposed to intraamniotic endotoxin in a chorioamnionitis model.Pediatr Res 2008;63:274-9.
Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Newnham JP, Ikegami M, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep.Am J Obstet Gynecol 2008;198:122.e1-e8.
Kallapur SG, Jobe AH, Ball MK, Nitsos I, Moss TJM, Hillman NH, Newnham JP, Kramer BW. Pulmonary and systemic endotoxin tolerance in preterm fetuses exposed to chorioamnionitis.J Immunol 2007;179:8491-9.
Hillman NH, Moss TJM, Kallapur SG, Bachurski CJ, Pillow JJ, Polglase G, Nitsos I, Kramer BW, Jobe AH. Brief large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep.Am J Respir Crit Care Med 2007;176:575-81.
Kramer BW, Joshi SN, Moss TJM, Newnham JP, Sindelaar R, Jobe AH, Kallapur SG. Endotoxin induced maturation of monocytes in preterm fetal sheep lung.Am J Physiol Lung Cell Mol Physiol 2007;293:L345-53.
Jobe AH, Moss TJM, Nitsos I, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: Testing dose and formulation in fetal sheep.Am J Obs Gyn 2007;197:523.e1-e6.
Book Chapters, Review Articles, and Editorials
Kramer BW, Kallapur SG, Newnham JP, Jobe AH. Prenatal Inflammation and Lung Development. Article for Seminars in Fetal and Neonatal Medicine for edition titled: Modern Respiratory Management of the Newborn. Eds. Hummler and Schulze. 2009;14:2-7.
Kallapur SG, Kramer BW, Jobe AH. Prenatal inflammation and immune responses of the preterm lung. In Bronchopulmonary Dysplasia. Ed. Abman SH. 2008 (In press).
Kallapur SG, Hillman NH. Inflammation and BPD. eNeonatal Review 2008 March edition. (Also created a podcast.)
Kallapur SG, Jobe AH. Antenatal Factors that influence postnatal lung development and injury. In Fetal and Neonatal Physiology (4th edition). Eds. Polin, Fox and Abman. W.B. Saunders and Co. Philadelphia, PA (2007)
Professional Organization Memberships
Teaching
Dr. Kallapur is the Director of Continuing Medical Education (CME) program in Neonatology and established CME category I activities in the Division in 1997. Dr. Kallapur has coordinated Neonatology's weekly Grand Rounds since its inception as a category I CME activity. He has also chaired the NeoFest conference since its inception in 1998. This regional half-day conference is devoted to a chosen theme and the faculty who present at this conference are leading experts, nationally and internationally renowned in the subject area. Dr. Kallapur also serves as a member of the planning committee for the two-day Midwest Critical care symposium for neonatologists and allied health care workers.
Special Interests
- Chorioamnionitis
- Bronchopulmonary dysplasia
- Respiratory distress syndrome
- Fetal immunity
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
