University of Cincinnati Department of Pediatrics

William C. Nichols, PhD

Title

Associate Professor

Appointment

Assistant Professor

Email

bill.nichols@cchmc.org

Phone

513-636-4717

Credentials

PhD: Department of Medical Genetics, Indiana University, Indianapolis, IN, 1983-89.

Associate, Howard Hughes Medical Institute, Ann Arbor, MI, 1989-91.

Research Fellow, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 1991-92.

Research Investigator, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 1992-1998.

Research Grants and Contracts

National Institutes of Health, NHLBI, “Cloning of Familial Primary Pulmonary Hypertension Gene” (R01 HL61997), W. Nichols, P.I., 30% effort, 08/01/03-07/31/09.

National Institutes of Health, NIAMS, “Juvenile Rheumatoid Arthritis as a Complex Genetic Trait” (N01 AR42218), D Glass, P.I.Co-investigator, 10% effort, 10/01/04-09/30/09.

Publications, Most Recent

Pankratz N, Marker KS, Halter CA, Rudolph A, Shults CW, Nichols WC, Foroud T, for the Parkinson Study Group – PROGENI Investigators. Clinical Correlates of Depressive Symptoms in Familial Parkinson’s Disease. Mov Disord, in press.

Nichols WC, Pankratz N, Marek D, Pauciulo MW, Elsaesser VE, Halter CA, Rudolph A, Wojcieszek J, Pfeiffer R, Foroud T, for the Parkinson Study Group – PROGENI Investigators. Mutations in GBA are associated with familial Parkinson disease susceptibility and age of onset. Neurology, in press.

Haugarvoll K, Rademakers R, Kachergus J, Nuytemans K, Ross OA, Gibson M, Tan E-K, Gaig C, Tolosa ES, Goldwurm S, Guidi M, Riboldazzi G, Brown L, Walter U, Benecke R, Berg D, Gasser T, Theuns J, Engelsborghs S, Pals P, Cras P, De Deyn PP, Barbara Pickut B, Uitti RJ, Foroud T, Nichols WC, Hagenah JM, Klein C, Samii A, Zabetian CP, Bonifati V, Broeckhoven C, Farrer MW, Wszolek Z. Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson’s disease. Neurology 70:1456-60, 2008.

Tada Y, Laudi S, Harral J, Carr M, Ivester C, Tanabe N, Takiguchi Y, Tatsumi K, Kuriyama T, Nichols WC, West J. Murine pulmonary response to chronic hypoxia is strain specific. Exp Lung Res 34:313-23, 2008.

Nichols WC, Marek DK, Pauciulo MW, Pankratz N, Halter CA, Rudolph A, Shults CW, Wojcieszek J, Foroud T, the Parkinson Study Group – PROGENI Investigators. R1514Q substitution in Lrrk2 is not a pathogenic Parkinson disease mutation. Mov Disord, 22:254-256, 2007.

Stewart DR, Cogan JD, Kramer MR, Miller WT Jr, Christiansen LE, Pauciulo MW, Messiaen LM, Tu GS, Thompson WH, Pyeritz RE, Ryu JH, Nichols WC, Kodama M, Meyrick BO, Ross DJ. Is pulmonary arterial hypertension in neurofibromatosis type 1 secondary to a plexogenic arteriopathy?Chest 132:798-808, 2007.

Nichols WC, Elsaesser VE, Pankratz N, Pauciulo MW, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T, for the Parkinson Study Group – PROGENI Investigators. LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8. Neurology 69:1737-44, 2007.

Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, Leikauf GD. Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol 37:309-21, 2007.

Pankratz N, Byder L, Halter C, Rudolph A, Shults CW, Conneally PM, Foroud T, Nichols WC, the Parkinson Study Group – PROGENI investigators. Presence of an APOE4 allele results in significantly earlier onset of Parkinson’s disease and a higher risk of dementia. Mov Disord 21:45-49, 2006.

Zhang B, McGee B, Yamaoka JS, Guglielmone H, Downes KA, Minoldo S, Jarchum G, Payvandi F, de Bosch NB, Ruiz-Saez A, Chatelain B, Olpinski M, Bockenstedt P, Sperl W, Kaufman RJ, Nichols WC, Tuddenham EGD, Ginsburg D. Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2. Blood 107:1903-1907, 2006.

Garringer HJ, Pankratz ND, Nichols WC, Reed T. Hearing impairment susceptibility in elderly men and the DFNA18 locus. Arch Otolaryngol Head Neck Surg 132:506-510, 2006.

Cogan JD, Pauciulo MW, Batchman AP, Prince MA, Robbins IM, Hedges LK, Stanton KC, Wheeler LA, Phillips III JA, Loyd JE, Nichols WC. High Frequency of BMPR2 Exonic Deletions/Duplications in Familial Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 174:590-598, 2006.

Pankratz N, Pauciulo MW, Elsaesser VE, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T, Nichols WC, the Parkinson Study Group – PROGENI Investigators. Mutations in LRRK2 other than G2019S are rare in a North American-based sample of familial Parkinson disease. Mov Disord 21:2257-2260, 2006.

Pankratz N, Pauciulo MW, Elsaesser VE, Marek DK, Halter CA, Wojcieszek J, Rudolph A, Shults CW, Foroud T, Nichols WC, the Parkinson Study Group – PROGENI Investigators. Mutations in DJ-1 are rare in familial Parkinson disease. Neurosci Lett 408:209-213, 2006.

Funalot B, Nichols WC, Perez-Tur J, Mercier G, Lucotte G. Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease. Genet Test 10:290-293, 2006.

Ishihara L, Warren L, Gibson R, Amouri R, Lesage S, Durr A, Tazir M, Wszolek ZK, Uitti RJ, Nichols WC, Griffith A, Hattori N, Leppert D, Watts R, Zabetian CP, Foroud TM, Farrer MJ, Brice A, Middleton L, Hentati F. Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations. Arch Neurol 63:1250-1254, 2006.

Professional Organization Memberships

Abstracts

Pauciulo MW, Clark KA, Wheeler LA, Loyd JE, Nichols WC. Towards identification of BMPR2 deletion/duplication breakpoints in familial pulmonary arterial hypertension. Poster presentation at the 57th Annual Meeting of the American Society of Human Genetics, San Diego, CA October 2007

Pauciulo MW, Clark KA, Wheeler LA, Loyd JE, Nichols WC. Towards identification of BMPR2 deletion/duplication breakpoints in familial pulmonary arterial hypertension. Poster presentation at the International Conference of the American Thoracic Society, San Francisco, CA, May 2007.

Pankratz N, Pauciulo MW, Elsaesser VE, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T, Nichols WC, the Parkinson Study Group – PROGENI investigators. Mutations in LRRK2 other than G2019S are rare in familial Parkinson disease. Poster presentation at the 56th Annual Meeting of the American Society of Human Genetics, New Orleans, LA October 2006

Nichols WC, Marek DK, Pauciulo MW, Pankratz N, Halter CA, Rudolph A, Shults CW, Wojcieszek J, Foroud T. R1514Q Substitution in Lrrk2 is not a pathogenic Parkinson disease mutation. Poster presentation at the 56th Annual Meeting of the American Society of Human Genetics, New Orleans, LA October 2006

Pauciulo MW, Liu L, Tuchfarber WA, Hale PT, Foroud T, Nichols WC. Using a murine model to identify genes important in pulmonary arterial hypertension. Poster presentation at the 56th Annual Meeting of the American Society of Human Genetics, New Orleans, LA October 2006

Pauciulo MW, Liu L, Tuchfarber WA, Hale PT, Foroud T, Nichols WC. Linkage evidence for loci contributing to hypoxia-induced pulmonary hypertension. Poster discussion presentation at the International Conference of the American Thoracic Society, San Diego, CA, May 2006.

Pauciulo MW, Cogan JD, Batchman AP, Prince MA, Hedges LK, Stanton KC, Wheeler LA, Robbins IM, Phillips JA, Loyd JE, Nichols WC. Exonic deletions/duplications of BMPR2 account for a significant proportion of mutations in familial pulmonary arterial hypertension (PAH). Poster discussion presentation at the International Conference of the American Thoracic Society, San Diego, CA, May 2006.

Nichols WC, Pauciulo MW, Elsaesser VE, Marek DK, Pankratz N, Halter CA, Rudolph A, Shults CW, Foroud T, the Parkinson Study Group – PROGENI investigators. Screening for known LRRK2 mutations in familial Parkinson disease. Poster presentation at the World Parkinson Congress, Washington, D.C., February 2006.

Special Interests

Elucidation of the molecular basis for primary pulmonary hypertension (PPH); mapping of genes contributing to Parkinson Disease (PD); mapping of genes contributing to juvenile rheumatoid arthritis (JRA); genetic mapping of other mendelian disorders.