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Nicolas Nassar, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-636-6597

Email: nicolas.nassar@cchmc.org

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Biography

Nicolas Nassar, PhD is a structural biologist interested in the structure/function of signaling proteins and in finding ways to inhibit their signaling in disease. More specifically, we are interested in how a given protein specifically binds and recognizes its regulators and targets. We have over the years focused on Ras-like GTPases. Recently, however we have been interested in a new family of protein tyrosine phosphatases (PTPs). We combine X-ray crystallography, site-directed mutagenesis, enzyme kinetics, and other biophysical techniques in our studies.

Education and Training

PhD: University Joseph Fourier, Grenoble – France (1992).

Postdoc: Max Plank Institut, Dortmund – Germany (1996).

Research Associate: Cornell University, Ithaca – NY (2000).

Assistant Professor: Stony Brook University, NY (2006).

Research Assistant Professor: Stony Brook University (2010).

Publications

Jackoncic J, Sondgeroth B, Carpino N, Nassar N. The 1.35 Å structure of the Phosphatase domain of the Suppressor of T Cell Receptor Signaling Protein in complex with Sulfate. Acta Cryst section F66, 2010 643-647.

Nassar N, Singh K, Garcia-Diaz M. Structure of the dominant negative S17N mutant of Ras. Biochemistry. 2010 49,1970-1974.

Ford B, Boykevisch S, Zhao C, Kunzelmann S, Bar-Sagi D, Herrmann C, Nassar N. Characterization of a Ras mutant with identical GDP- and GTP-bound structures. Biochemistry. 2009 48,11449-11457.

Carpino N, Chen Y, Nassar N, Hye-Won Oh. The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways. in review. J. Immuno. 2009 46,3224-3231.

Chen Y, Jakoncic J, Parker KA, Carpino N, Nassar N. Structures of the Phosphorylated and VO3-bound 2H-Phosphatase Domain of Sts-2. Biochemistry. 2009 48, 8129-8135.

Chen Y, Jakoncic J, Carpino N, Nassar N. Structural and Functional Characterization of the 2H-phosphatase domain of Sts-2 reveals an Acid-Dependent Phosphatase Activity. Biochemistry. 2009 48,1681-1690.

Chen Y, Jakoncic J, Keller J, Wang J, Zheng X, Carpino N, Nassar N. Structural and functional characterization of the C-terminal domain of the ecdysteroid phosphate phosphatase from Bombyx mori. Biochemistry. 2008 47,12135-12145.

Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N. The C-terminal mutase-like domain of Sts-1 is important for its T-cell suppressor activity. Molecular Cell. 2007 27, 486-487.