Developmental biology; pulmonary biology
Debora Sinner, PhD, obtained her doctoral degree from University of Buenos Aires, Argentina. Her dissertation focused on the effects of maternal diabetes during murine embryonic development and role of prostaglandins and reactive species of oxygen in glucose induced abnormal development. As a postdoctoral trainee in the Division of Developmental Biology at Cincinnati Children's, Dr. Sinner focused on the molecular mechanisms underlying endoderm formation, the germ layer that gives rise to the gastrointestinal tract. Under the direction of her mentor, Aaron Zorn, PhD
, we identified a mechanism by which Sox proteins regulate the Wnt signaling pathway during frog development. These findings are relevant since Wnt signaling pathway has been linked to development and disease.
After completion of her doctoral training, Dr. Sinner accepted a faculty position in the Division of Neonatology and Pulmonary Biology. Her current research focuses on upper airway and lung development. Dr. Sinner's lab is studying how paracrine Wnt signaling controls the differentiation of pulmonary cells lineages, including the microvasculature and airway cartilage.
Education and Training
MS: University of Buenos Aires, Argentina, 1999.
PhD: University of Buenos Aires, Argentina, 2003.
Post doctoral training: Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003-2009.
View PubMed Publications
Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn. 2010 Jan;239(1):56-68.
Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.
Sinner D, Kordich JJ, Opoka R Rankin SA,. Lin S-J, Jonatan D, Zorn AM, Wells JM. Beta-catenin/Tcf activity is repressed by Sox17 and enhanced by Sox4 in colon carcinoma cells. Mol Cell Biol. 2007;27:7802-7815.
Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development. 2006 May;133(10):1955-66.
Sinner D, Rankin S, Lee M, Zorn AM. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development. 2004 Jul;131(13):3069-80.
Sinner D, Caviglia JM, Jawerbaum A, Igal RA, Gonzalez E. Lipid metabolism in the embryos of diabetic rats during early organogenesis: modulatory effect of prostaglandin E2. Reprod Fertil Dev. 2003;15(1-2):75-80.
"Molecular mechanisms underlying lung growth and hypoplasia: Role of Wntless" Basil O' Connor Starter Scholar Research Award. March of Dimes. 2/1/2012-1/30/2014
"Molecular mechanisms underlying upper airway patterning and tracheomalacia" K01 NIH-NHLBI 8/1/2012-7/31/2017