Biographies

Debora I. Sinner, PhD

Instructor, UC Department of Pediatrics

Phone: 513-803-1353

Email: debora.sinner@cchmc.org

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Specialties

Developmental biology; pulmonary biology

Visit the Sinner Lab.

Biography

Debora Sinner, PhD, obtained her doctoral degree from University of Buenos Aires, Argentina. Her dissertation focused on the effects of maternal diabetes during murine embryonic development and role of prostaglandins and reactive species of oxygen in glucose induced abnormal development. As a postdoctoral trainee in the Division of Developmental Biology at Cincinnati Children's, Dr. Sinner focused on the molecular mechanisms underlying endoderm formation, the germ layer that gives rise to the gastrointestinal tract. Under the direction of her mentor, Aaron Zorn, PhD, we identified a mechanism by which Sox proteins regulate the Wnt signaling pathway during frog development. These findings are relevant since Wnt signaling pathway has been linked to development and disease.

After completion of her doctoral training, Dr. Sinner accepted a faculty position in the Division of Neonatology and Pulmonary Biology. Her current research focuses on upper airway and lung development. Dr. Sinner's lab is studying how paracrine Wnt signaling controls the differentiation of pulmonary cells lineages, including the microvasculature and airway cartilage.

Education and Training

MS: University of Buenos Aires, Argentina, 1999.

PhD: University of Buenos Aires, Argentina, 2003.

Post doctoral training: Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003-2009.

Publications

View PubMed Publications

Grants

"Molecular mechanisms underlying lung growth and hypoplasia: Role of Wntless" Basil O' Connor Starter Scholar Research Award. March of Dimes. 2/1/2012-1/30/2014

"Molecular mechanisms underlying upper airway patterning and tracheomalacia" K01  NIH-NHLBI 8/1/2012-7/31/2017