Kris A. Steinbrecher, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-5581

Email kris.steinbrecher@cchmc.org

Research

Inflammatory bowel disease; bacterial infection; signal transduction and gene expression in intestinal epithelial cells

Visit the Steinbrecher Lab.

PhD: Molecular and Developmental Biology, University of Cincinnati, Cincinnati, OH, 2001.

Postdoctoral Fellowship: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 2001-2005.

Xin L, Jiang TT, Chaturvedi V, Kinder JM, Ertelt JM, Rowe JH, Steinbrecher KA, Way SS. Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10672-7.

Begg DP, Steinbrecher KA, Mul JD, Chambers AP, Kohli R, Haller A, Cohen MB, Woods SC, Seeley RJ. Effect of guanylate cyclase-C activity on energy and glucose homeostasis. Diabetes. 2014 Jun 4. Epub ahead of print.

Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA,Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS. Thrombin drives tumorigenesis in colitis-associated colon cancer. Cancer Res2014 Jun 1;74(11):3020-30.

Steinbrecher KA. The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor. Curr Opin Gastroenterol. 2014 Jan;30(1):1-6.

Harmel-Laws E, Mann EA, Cohen MB, Steinbrecher KA. Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis. PLoS One. 2013 Nov 11;8(11):e79180.

Elahi S, Ertelt JM, Kinder JM, Jiang TT, Zhang X, Xin L, Chaturvedi V, Strong BS, Qualls JE, Steinbrecher KA, Kalfa TA, Shaaban AF, Way SS. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature. 2013 Dec 5;504(7478):158-62.

Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, Sheridan R, Xanthakos SA, Steinbrecher KA, Sartor RB, Kohli R, Karp CL, Divanovic S. IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology. 2014 May;59(5):1830-9.

Mann EA, Harmel-Laws E, Cohen MB, Steinbrecher KA. Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen. BMC Gastroenterol. 2013 Sep 2;13:135.

Waddell A, Ahrens R, Tsai YT, Sherrill JD, Denson LA, Hogan SP, Steinbrecher KA. Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice. J Immunol. 2013 May 1;190(9):4773-85.

Steinbrecher KA, Harmel-Laws E, Garin-Laflam MP, Mann EA, Bezerra LD, Hogan SP, Cohen MB. Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol. 2011 Jun 15;186(12):7205-14.