Paul E. Steele, MD, is medical director of the clinical laboratory at Cincinnati Children's Hospital Medical Center, arriving in 1999. He came to Children's Hospital Medical Center of Cincinnati from University Hospital of Cincinnati, where he was a member of the laboratory medicine staff for 11 years.
Dr. Steele's background includes general laboratory directorship, as he was medical director of University Hospital's Immediate Response Laboratory for over two years before coming to Cincinnati Children's.
Dr. Steele has also served as medical director of Diagnostic Immunology since arriving at University Hospital. In this position, he was involved in humoral immunology, including infectious disease serology, autoimmune testing, protein characterization, and allergy testing; he was also involved in flow cytometry, including transplantation, stem cell and HIV monitoring, as well as evaluation and monitoring of hematopoietic neoplasms.
Dr. Steele has also been involved in molecular pathology. At University Hospital, he put in place a molecular diagnostics laboratory which provided molecular genetic detection of lymphoid clonality as well as chromosomal translocation in chronic myelocytic leukemia. At Children's Hospital Medical Center of Cincinnati, he has become a participant in overseeing the molecular genetic testing for infectious disease.
Dr. Steele's research interests include the evaluation of human endogenous retroviral sequences and their role in human pathology. This work is an outgrowth of studies he began as a postdoctoral fellow at the National Institutes of Health.
Specifically, Dr. Steele has created antisera to a biosynthetic fusion protein containing a portion of a human endogenous retroviral envelope gene that encodes a putative immunosuppressive protein. This antisera detects a human protein which is the subject of Dr. Steele's study.