Shiva K. Shanmukhappa, DVM, PhD, Diplomate ACVP

Assistant Professor, UC Department of Pathology & Laboratory Medicine

Phone: 513-803-4289


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Liver repair and regeneration; NASH; metabolic complication of HIV; sickle cell disease; nephropathy.


Shiva Kumar Shanmukhappa joined the Cincinnati Children's Division of Pathology and Laboratory Medicine in 2012 as an assistant professor of pathology overseeing the research pathology core.

From 2009-2012, Dr. Shanmukhappa was a comparative pathology fellow Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School. 

Dr. Shanmukhappa was research fellow in Division of Gastroenterology, Hepatology and Nutrition from 2003 to 2009 where he primarily worked on understanding the molecular mechanism involved in liver repair and regeneration as well as the induction of pancreatic cells in liver during defective liver repair. He identified the role of plasmin in liver repair. He has shown that plasmin mediates liver repair through the activation of HGF-MET signaling mainly affecting cell motility.

Dr. Shanmukhappa has an active research career with his primary interests in molecular control of liver repair, regeneration, biliary atresia, NASH and metabolic complications of HIV.

Education and Training

DVM: Veterinary College, University of Agricultural Sciences, Bangalore, India,1996.

PhD: Department of Veterinary Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 2002.

Residency: Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA.

Certification: Veterinary Anatomic Pathology, 2013.


View PubMed Publications


12.5 % effort, Digestive Health Center, Cincinnati Children’s Hospital Medical Center. Public Health Service Grant. Jan 2013 – Current. P30 DK078392.