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Shiva K. Shanmukhappa, DVM, PhD, Diplomate ACVP

Assistant Professor, UC Department of Pathology & Laboratory Medicine

Phone 513-803-4289

Email shiva.shanmukhappa@cchmc.org

Research

Liver repair and regeneration; NASH; metabolic complication of HIV; sickle cell disease; nephropathy.

Shiva Kumar Shanmukhappa joined the Cincinnati Children's Division of Pathology and Laboratory Medicine in 2012 as an assistant professor of pathology overseeing the research pathology core.

From 2009-2012, Dr. Shanmukhappa was a comparative pathology fellow Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School. 

Dr. Shanmukhappa was research fellow in Division of Gastroenterology, Hepatology and Nutrition from 2003 to 2009 where he primarily worked on understanding the molecular mechanism involved in liver repair and regeneration as well as the induction of pancreatic cells in liver during defective liver repair. He identified the role of plasmin in liver repair. He has shown that plasmin mediates liver repair through the activation of HGF-MET signaling mainly affecting cell motility.

Dr. Shanmukhappa has an active research career with his primary interests in molecular control of liver repair, regeneration, biliary atresia, NASH and metabolic complications of HIV.

DVM: Veterinary College, University of Agricultural Sciences, Bangalore, India,1996.

PhD: Department of Veterinary Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 2002.

Residency: Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA.

Certification: Veterinary Anatomic Pathology, 2013.

Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA. Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia. BMC Syst Biol. 2013 Oct 20;7:104.

Marzioni M, Saccomanno S, Agostinelli L, Rychlicki C, De Minicis S, Pierantonelli I, Trauner M, Fickert P, Müller T, Shanmukhappa K, Trozzi L, Candelaresi C, Baroni GS, Benedetti A. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis. J Hepatol. 2013 Apr;58(4):750-6.

Sasseville VG, Mansfield KG, Mankowski JL, Tremblay C, Terio KA, Mätz-Rensing K, Gruber-Dujardin E, Delaney MA, Schmidt LD, Liu D, Markovits JE, Owston M, Harbison C, Shanmukhappa SK, Miller AD, Kaliyaperumal S, Assaf BT, Kattenhorn L, Macri SC, Simmons HA, Baldessari A, Sharma P, Courtney C, Bradley A, Cline JM, Reindel JF, Hutto DL, Montali RJ, Lowenstine LJ. Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies. Vet Pathol. 2012 Nov;49(6):1057-69.

Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K. Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing. PLoS One. 2011;6(7):e21979.

Mann EA, Shanmukhappa K, Cohen MB. Lack of guanylate cyclase C results in increased mortality in mice following liver injury. BMC Gastroenterol. 2010 Aug 2;10:86.

Marzioni M, Saccomanno S, Candelaresi C, Rychlicki C, Agostinelli L, Shanmukhappa K, Trozzi, L, Pierantonelli I, De Minicis S, Benedetti A. Pancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation. J Hepatol. 2010 Oct;53(4):663-70.

Shanmukhappa K, Degen J, Bezerra J. Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009 May 8;284(19): 12917-12923.

Shanmukhappa K, Kim JK and Kapil S. Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection. Virol J. 2007; 4: 62.

Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40.

Kim JK, Fahad AM, Shanmukhappa K, Kapil S. Defining the cellular target(s) of porcine reproductive and respiratory syndrome virus blocking monoclonal antibody 7G10. J Virol. 2006 Jan;80(2):689-96.

12.5 % effort, Digestive Health Center, Cincinnati Children’s Hospital Medical Center. Public Health Service Grant. Jan 2013 – Current. P30 DK078392.