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High Res

Umasundari Sivaprasad

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-1629

Fax: 513-636-1657

Email: siv9ni@cchmc.org

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Specialties

Visit the Sivaprasad Lab.

Allergic inflammation; atopic dermatitis; asthma; development of anti-inflammatory therapies

Education and Training

BS: St. Xavier’s College, Mumbai, India, 1993.

MS: The University of Mumbai, India, 1995.

PhD: The Ohio State University, 2003.

Postdoctoral Research Associate: University of Virginia, 2003-2007.

Publications

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Sivaprasad, U., Canfield, J. M., Brooks, C. L. Mechanism of Ordered Lactogen Receptor Binding by Human Prolactin. Biochemistry. 43(43):13755-65. 2004.

Senga, T.S.*, Sivaprasad, U.*, Zhu, W.*, Park, J.H., Arias, E., Walter, J.C., Dutta, A., PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J. Biol Chem. 281(10): 6246-52. * Co-first authors. 2005.

Sivaprasad, U., Abbas, T., Dutta, A., Differential efficacy of 3-hydroxy 3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. Mol. Cancer Ther. 5(9):2310-16. 2006.

Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano M., Dutta, A., PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4^Cdt2 ubiquitin ligase complex. Genes and Dev. 22(18):2496-2506. PMCID: PMC2546691. 2008.

Chen, W., Sivaprasad, U., Tabata, Y., Gibson, A.M., Stier, M.T., Finkelman, F.D., Hershey, G.K., IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice. J Immunol. 183(12): 7870-76. PMCID: PMC2822278. 2009.

Sivaprasad, U., Warrier, M.R., Gibson, A.M., Chen, W., Tabata, Y., Bass, S.A., Rothenberg, M.E., Khurana Hershey, G.K., IL-13 Receptor Alpha2 has a protective role in a mouse model of cutaneous inflammation. J Immunol. 185(11):6802-8. 2010.

Sivaprasad, U., Askew, D.J., Ericksen, M.B., Gibson, A.M., Stier, M.S., Brandt, E., Bass, S.A., Daines, M.O., Chakir, J., Stringer, K.F., Wert, S.E., Whitsett, J.A., Le Cras, T.D., Wills-Karp, M., Silverman, G.A., Khurana Hershey, G.K., A non-redundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin. Immunol. 127(1):254-261.e6. PMCID: PMC3058372. 2010.

Butsch Kovacic, M., Biagini Myers, JM., Patterson, TL, Lindsey, M., Ericksen, MB, He, H., Gupta, J., Sivaprasad, U., Gibson, AM., Tsoras, AM, Chen, W., Musaad, S., Baye, TM, Khurana Hershey, G.K. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences. PLoS One 6(8):e23714 PMCID: PMC3166061. 2011.

Wills-Karp, M., Rani, R., Dienger, K., Lewkowich, I., Fox, J.G., Perkins, C., Lewis, L., Finkelman, F.D., Smith, D.E., Bryce, P.J., Kurt-Jones, E.A., Wang, T.C., Sivaprasad, U., Hershey, G.K., Herbert, D.R. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J. Exp. Med. 209(3):607-22. PMCID: PMC3302229. 2012.

Chen, W., Sivaprasad, U., Gibson, A.M., Ericksen M.B., Cunningham C.M., Bass, S.A., Kinker, K.G., Finkelman, F.D., Wills-Karp, M., Khurana Hershey, G.K. IL-13 Receptor Alpha 2 Contributes to Development of Experimental Allergic Asthma. J Allergy Clin. Immunol In Press. 2013.