Umasundari Sivaprasad

Assistant Professor, UC Department of Pediatrics

Phone 513-636-1629

Fax 513-636-1657

Email siv9ni@cchmc.org

Visit the Sivaprasad Lab.

Allergic inflammation; atopic dermatitis; asthma; development of anti-inflammatory therapies

Dr. Sivaprasad received dual BS degrees in microbiology and biochemistry (St. Xavier’s College), as well as an MS degree in biochemistry from the University of Mumbai, India. She then received her PhD degree in biochemistry from The Ohio State University in 2003 where she used surface plasmon resonance (Biacore™) technology and other biochemical methods to delineate the mechanism of prolactin binding to its cognate receptor. Her postdoctoral training in the Department of Biochemistry and Molecular Genetics at the University of Virginia was focused on elucidating the molecular mechanisms that regulate formation of the pre-replication complex during DNA replication initiation along with studies examining the effect of statins on regulation of prostate cancer cell proliferation.

In 2007 Dr. Sivaprasad joined the Division of Asthma Research with a view to developing statins as an alternative to steroids as anti-inflammatory therapy in asthma and allergic diseases. Along the way, she has developed an interest in elucidating the role of serine protease inhibitors in allergic pathophysiology. Since joining the division she has served as first author or co-author on eight peer-reviewed publications.

The long-term goal of Dr. Sivaprasad’s research is to better understand the molecular basis of allergic diseases. To this end she is utilizing her broad repertoire of skills developed during her training to apply in vitro biochemical, molecular, as well as in vivo animal model approaches to her research questions, specifically the role of serine protease inhibitors at the epithelial barriers in the lung, skin, and intestine.

She has ongoing collaborations with investigators at the University of Pittsburgh and in the Divisions of Pulmonary Biology, Immunobiology, and Pathology at Cincinnati Children’s.

BS: St. Xavier’s College, Mumbai, India, 1993.

MS: The University of Mumbai, India, 1995.

PhD: The Ohio State University, 2003.

Postdoctoral Research Associate: University of Virginia, 2003-2007.

Chen W, Sivaprasad U, Gibson AM, Ericksen MB, Cunningham CM, Bass SA, Kinker KG, Finkelman FD, Wills-Karp M, Khurana Hershey GK. IL-13 receptor α2 contributes to development of experimental allergic asthma. J Allergy Clin Immunol. 2013 Oct;132(4):951-8.

Wills-Karp M, Rani R, Dienger K, Lewkowich I, Fox JG, Perkins C, Lewis L, Finkelman FD, Smith DE, Bryce PJ, Kurt-Jones EA, Wang TC, Sivaprasad U, Hershey GK, Herbert DR. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med. 2012 Mar 12;209(3):607-22.

Schroer KT, Gibson AM, Sivaprasad U, Bass SA, Ericksen MB, Wills-Karp M, LeCras T, Fitzpatrick AM, Brown LA, Stringer KF, Khurana Hershey GK.  Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress. J Allergy Clin Immunol. 2011 Sep;128(3):539-48.

Butsch Kovacic M, Biagini Myers JM, Patterson TL, Lindsey M, Ericksen MB, He H, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Chen W, Musaad S, Baye TM, Khurana Hershey GK. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences. PLoS One. 2011; 6(8):e23714.

Brandt EB, Sivaprasad U. Th2 cytokines and atopic dermatitis. J Clin Cellular Immunol. 2011 Aug 10;2(3).

Sivaprasad U, Warrier MR, Gibson AM, Chen W, Tabata Y, Bass SA, Rothenberg ME, Khurana Hershey GK. IL-13 Receptor Alpha 2 has a protective role in a mouse model of cutaneous inflammation. J Immunol. 2010 Dec 1;185(11):6802-8.

Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MS, Brandt E, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK.  A non-redundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61.

Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson A, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21.

Chen W, Sivaprasad U, Tabata Y, Gibson AM, Stier MT, Finkelman FD, Hershey GK. IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice. J Immunol.  2009 Dec 15;183(12):7870-6.

Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes  Dev. 2008 Sep 15;22(18):2496-506.