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Biographies

Find another Doctor or Researcher

Christopher Baum, MD

Adjunct Associate Professor

Associate Professor, UC Department of Pediatrics

Phone: 513-636-1333

Email: christopher.baum@cchmc.org

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Specialties

Clinical Interests

Retrovirus biology and vectorology; stem cell biology; gene therapy; leukemia biology

Biography

Christopher Baum, MD was born April 13, 1962 in Marburg, Germany. He studied philosophy and medicine in Freiburg and Hamburg, Germany. He received his certification and MD in 1991. In 1992, Baum pursued postgraduate training in molecular biology at the University of Hamburg; his focus was the expression analysis of novel Nkx homeobox genes. Since 1996, he has led the research group in retroviral vector development for genetic modification of hematopoietic cells at Heinrich-Pette-Institut in Hamburg. In 2000, Baum moved his lab to Hannover Medical School (Germany), one of the largest centers for organ transplantation in Europe. Since April 2006 Dr. Baum is Full Professor and Head of the Department of Experimental Hematology at the Hannover Medical School. He works as an Adjunct Associate Profesor in Cincinnati Children's Hospital since July 2002.

Education and Training

MD: University of Hamburg, Germany, 1991.

Publications

View PubMed Publications

Arumugam PI, Higashimoto T, Urbinati F, Modlich U, Nestheide S, Xia P, Fox C, Corsinotti A, Baum C, Malik P. Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region. Mol Ther. 2009 Nov;17(11):1929-37.

Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, Thomale J, Williams DA. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res. 2008 Aug 1;68(15):6171-80.

Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, Reeves L, Williams DA. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Mol Ther. 2007 Apr;15(4):782-91.

Will E, Speidel D, Wang Z, Ghiaur G, Rimek A, Schiedlmeier B, Williams DA, Baum C, Ostertag W, Klump H. HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues. Cell Cycle. 2006 Jan;5(1):14-22.

Schambach, A, Schiedlmeier B, Kuhicke K, Verstegen M, Margison G, Li Z, Kamino K, Bahne J, Alexandrov A, Hermann FG, von Laer D, Baum C. Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.Gene Therapy 2006; 13:1037-1047.

Von Kalle C, Fehse B, Layh-Schmitt G, Schmidt M, Kelly P, Baum C. Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable. Semin Hematol. 2004 Oct;41(4):303-18.

Schambach A, Galla M, Modlich U, Will E, Chandra S, Reeves L, Colbert M, Williams DA, von Kalle C, Baum C. Lentiviral vectors pseudotyped with murine ecotropic evelope: Increased biosafety and convenience for preclinical research. Experimental Hematology. 2006; 34-588-592.

Schambach A, Bohne J, Baum C, Hermann FG, Egerer L, von Laer D, Giroglou T. Woodchuck hepatitis virus posttranscriptional regulatory element deleted from X protein enhances retroviral vector titer and expression. Gene Therapy. 2006; 13:241-246.

Kustikova O, Fehse B, Modlich U, Düllmann J, Kamino K, von Neuhoff N, Schlegelberger B, Li Z, Baum C. Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science. 2005 May 20;308(5725):1171-4.

Galla M, Will E, Kraunus J, Chen L, Baum C. Retroviral pseudotransduction for targeted cell manipulation. Mol Cell. 2004 Oct 22;16(2):309-15.