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A photo of Cyndi Bachurski.

High Res

Cindy J. Bachurski, PhD

Director, Neonatology and Pulmonary Biology Elective Rotation, University of Cincinnati, School of Medicine

Director, High School Senior Summer Internship Program, Cincinnati Children's Hospital Medical Center

Director, Excellence in Science Education and Learning (ExSEL) II Program, PATHWAYS to Health Careers, University of Cincinnati College of Medicine

Associate Professor, UC Department of Pediatrics

Phone: 513-636-8918

Fax: 513-636-7868

Email: cindy.bachurski@cchmc.org

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Specialties

Research Interests

Epithelial remodeling in lung injury / repair; transcription factor interactions in lung development; regulation of the Type II cell phenotype / lung epithelial progenitor cells; regulation of late lung development / BPD

Biography

Cindy Bachurski, PhD, is an Associate Professor in the Division of Pulmonary Biology at Cincinnati Children's Research Foundation (CCRF) and the Department of Pediatrics at the University of Cincinnati.

Dr. Bachurski's laboratory studies transcriptional control of the establishment and maintenance of the pulmonary Type II cell. She uses sophisticated transgenic mouse technology and molecular and biochemical analysis methods to ask mechanistic questions about transcription factor interactions during lung development, and in response to injury.

Dr. Bachurski has a long-term interest in mentoring young scientists. She organized a Research Explorer Scout Troop for high school students (1997 to 2001). She is currently the director of the Summer Internship Program at Cincinnati Children's, for graduating high school students to work with clinician-mentors. She also co-chairs the Cincinnati Children's High School Science Symposium honoring outstanding, local high school students and their teachers.

She is an active member of the Cincinnati Children's Women's Faculty Association where she has chaired several committees, organized workshops on Mentoring, and the Faculty Development page for the Cincinnati Children's web site.

Starting in the summer of 2008, Dr. Bachurski also directs the ExSELII program in which the best students from the Howard Hughes Medical Institute funded ExSEL program are invited to work full time on a mentored research lab project for 9 weeks in the summer. Click here to access the HHMI summer programs.

Education and Training

PhD: Microbiology, University of Maryland, College Park, MD, 1990.

Postdoctoral Fellowship: Biological Chemistry, Johns Hopkins University, Baltimore, MD, 1990 to 1992.

Postdoctoral Fellowship: Pulmonary Biology, Children's Hospital Research Foundation, Cincinnati, OH, 1992 to 1994.

Publications

View PubMed Publications

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. Surfactant associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol. 2009 Aug;41(2):226-36.

Kessler CA, Bachurski CJ, Schroeder J, Stanek J, Handwerger S. TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells. Mol Cell Endocrinol. 2008;295: 32-8.

Hillman NH, Moss TJ, Nitsos I, Kramer BW, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptor and Agonist Responses in the Developing Fetal Sheep Lung. Pediatr Res Pediatr Res. 2008;63:388-93.

Hillman NH, Moss TJ, Kallapur SG, Bachurski C, Pillow JJ, Polglase GR, Nitsos I, Kramer BW, Jobe AH. Brief, Large Tidal Volume Ventilation Initiates Lung Injury and a Systemic Response in Fetal Sheep. Am J Respir Crit Care Med. 2007;176: 575-81.

Wilson TC, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs. Pediatr Res. 2005;58:1204-9.

Steele-Perkins G, Plachez C, Butz KG, Yang G, Bachurski CJ, Kinsman SL, Litwack ED, Richards LJ, Gronostajski RM. The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development. Mol Cell Biol. 2005;25:685-98.

Bachurski CJ, Yang GH, Currier TA, Gronostajski R, Hong D. Nuclear Factor I / Thyroid Transcription Factor 1 interactions modulate Surfactant Protein C transcription. Molecular Cellular Biology.2003;23:9014-24.

DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC, Whitsett JA. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival and tissue specific gene expression. Journal of Biological Chemistry. 2003;278:35574-83.

Ikegami MI, Moss TJ, Kallapur SG, Mulrooney N, Kramer BW, Nitsos I, Bachurski CJ, Newnham JP, Jobe AH. Minimal lung and systemic responses to TNF in preterm sheep. Am J of Physiol Lung Cell Mol Physiol. 2003;285:L121-9.

Kallapur SG, Kramer BW, Moss TJM, Newnham JP, Jobe AH, Ikegami M, Bachurski CJ. Maternal glucocorticoids increase endotoxin induced lung inflammation in preterm lambs. American Journal of Physiological Lung Cellular Molecular Physiology. 2003;284(4):L633-42.

Grants

HHMI Precollege Outreach Initiative for Biomedical Research Institutions. Cincinnati Children's Liaison. Mentoring Community Outreach Grant. Sep 2007- Aug 2012.

Cincinnati Center for Clinical and Translational Science and Training. Cincinnati Children's Liaison.
National Institutes of Health. Aug 2009 - Mar 2014. #U54RR025216-01.

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Research » S » Section of Neonatology, Perinatal and Pulmonary Biology » Faculty

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