Elisa Boscolo, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7267

Email elisa.boscolo@cchmc.org

Research

Vascular anomalies; endothelial cell biology; mTOR signaling

Elisa Boscolo received her PhD from the University of Padua, Italy. She completed her postdoctoral training and worked as instructor in Joyce Bischoff ‘s laboratory where she investigated the cellular basis and the molecular signaling involved in infantile hemangioma formation. In May 2014, Dr. Boscolo moved to Cincinnati Children’s Hospital Medical Center to study vascular anomalies.

BS: Molecular Biology, University of Padua, Padova, Italy.

PhD: Tissue Engineering, University of Padua, Padova, Italy.

Postdoctoral Fellowship: Vascular Biology, Boston Children’s Hospital, Harvard Medical School, Cambridge, MA.

Lee D, Boscolo E, Durham JT, Mulliken JB, Herman IM, Bischoff J. Propranolol Targets Contractility of Infantile Hemangioma-derived Pericytes. Br J Dermatol. 2014 Apr 10. Epub ahead of print.

Smadja DM, Guerin CL, Boscolo E, Bieche I, Mulliken JB, Bischoff J. α6-integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells. Stem Cells. 2014; 32(3):684-93.

Boscolo E, Mulliken JB, Bischoff J.  Pericytes from Infantile Hemangioma Display Pro-angiogenic Properties and Dysregulated Angiopoietin-1. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):501-9.

Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE. SOCS3 is an endogenous Inhibitor of pathologic angiogenesis. Blood. 2012; 120(14):2925-9.

Boscolo E, Mulliken JB, Bischoff J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol. 2011 Nov;179(5):2266-77.

Greenberger S, Yuan S, Walsh LA, Boscolo E, Kang KT, Matthews B, Mulliken JB, Bischoff J. Rapamycin Suppresses Self-Renewal and Vasculogenic Potential of Stem Cells Isolated from Infantile Hemangioma. J Invest Dermatol. 2011 Dec;131(12):2467-76.

Boscolo E, Stewart CL, Greenberger S, Wu JK, Durham JT, Herman IM, Mulliken JB, Kitajewski J, Bischoff J. JAGGED1 Signaling Regulates Hemangioma Stem Cell-to-Pericyte/Vascular Smooth Muscle Cell Differentiation. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2181-92.          

Greenberger S, Boscolo E, Adini I, Mulliken JB, Bischoff J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med. 2010 Mar 18;362(11):1005-13. 

Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med. 2008 Nov;14(11):1236-46.

Khan ZA*, Boscolo E*, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest. 2008 Jul;118(7):2592-9.

Venous Malformation (VM): murine model to identify therapies to target aberrant venous development. Principal Investigator. National Institutes of Health. 2013-2018.

Role of NOTCH signaling during pathological blood vessel formation and maturation. Principal Investigator. Charles H. Hood Foundation. 2011-2014.