James P. Bridges, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-636-0337

Fax 513-636-7868

Email james.bridges@cchmc.org

Airway smooth muscle remodeling in chronic lung disease; identification/function of HIF target genes in pulmonary epithelium; transcriptional control of epithelial plasticity during lung Injury/remodeling

James Bridges, PhD, investigates the role of hypoxia inducible factors (HIFs) and downstream gene targets in chronic lung disease. These goals are achieved by utilizing both gain and loss-of-function mouse models to evaluate the mechanistic basis underlying the pathophysiologic changes in pulmonary function associated with altered HIF activity.

BS: Biochemistry, University of Colorado at Boulder, CO, 1995.

PhD: Molecular and Developmental Biology, University of Cincinnati, Cincinnati, OH, 2005.

Post-doctoral training: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010.

Bridges JP, Ikegami M, Mason RJ, Shannon JM. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. Journal of Clinical Investigation, 2010; 120(5):1736.

Wang M, Bridges JP, Na CL, Xu Y, Weaver TE. The Meckel-Gruber Syndrome Protein MKS3 is Required for ER-Associated Degradation of Surfactant Protein C. Journal of Biological Chemistry, 2009;  284:33377-83.

Ahmad A, Ahmad S, Glover L, Miller S, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2α in pulmonary endothelial cells. Proc Natl Acad Sci, 2009; 106(26):10684-9.

Dong M, Bridges JP, Apsley K, Xu Y, Weaver TE. ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C. Molecular Biology of the Cell, 2008; 19(6):2620-2630

Bridges JP, Panos RJ. Surfactant Protein C related Interstitial Lung Disease. In: McCormack FX, Rounds S, eds. Molecular Basis of Pulmonary Disease: Insights from Rare Lung Disorders. Totowa, NJ: Humana, 2008.