Developmental genetics of mammalian lens and retinal formation

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BA: Southern Illinois University, Biology and Chemistry, Edwardsville, IL, 1982

PhD: University of Wisconsin, Cellular and Molecular Biology, 1994

Postdoctoral Fellow: University of Michigan, Department of Biology, 1995-1996

Postdoctoral Fellow: University of Michigan Medical School, Division of Internal Medicine and Department of Human Genetics, 1996-1999

Prasov, L, Brown, NL and Glaser, T. A critical analysis of Atoh7 (Math5) splicing in the developing mouse retina.  PLoS One. 2010; Aug 5(8):e12315.

Macgregor S, Hewitt AW, Hysi PG, Ruddle JB,Medland SE, Henders AK, Gordon SD, Andrew T, McEvoy B, Sanfilippo PG, Carbonaro F, Tah V, Li YJ, Bennett SL, Craig JE, Montgomery GW, Tran-Viet KN, Brown NL, Spector TD, Martin NG, Young TL, Hammond CJ, Mackey DA. Genome-wide association identifies ATOH7 as a major gene determining human optic nerve size. Human Molecular Genetics. 2010; Apr 15;340(2):490-503. 

Hufnagel RB, Le TT, Riesenberg AL, Brown NL. Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Developmental Biology. 2010;340:490-503.

Riesenberg AN, Liu Z, Kopan R, Brown NL. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. Journal of Neuroscience. 2009;29(41): 12865-77.

Riesenberg AN, Le TT, Willardson MI, Blackburn DC, Vetter ML, Brown NL. Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis. 2009;47(3):175-187.

Le TT, Conley K, Brown NL. Jagged1 is necessary for normal mouse lens development. Developmental Biology. 2009;328(1):118-126.

Willardson MI, Suli A, Pan Y, Marsh-Armstrong N, El-Hodiri H, Chen CB, Moore KB, Brown NL, Vetter ML. Temporal regulation of Ath5 gene expression during eye development. Developmental Biology. 2009;326(2):471-481.

Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophth Vis Sci. 2009;50(1):432-440.

Rowan S, Conley K, Le TT, Donner AL, Maas RL, Brown, NL. Notch signaling is required for mouse lens growth and differentiation. Developmental Biology. 2008; 321(1):111-122.

Blackburn DC*, Conley K*, Platchetzki D, Kempler K, Battelle BA, Brown NL. Isolation and expression of Pax6 and atonal homologues in the American Horseshoe Crab, Limulus polyphemus. Developmental Dynamics. 2008;237(8):2209-2219.

Hufnagel RB, Riesenberg AN, Saul SM, Brown NL. Conserved regulation between Math5 and Math1 as revealed by Math5-GFP transgenes. Molecular and Cellular Neuroscience. 2007;36(4):435-488.

Book Chapters

Brown N.L. Ganglion cell development: early steps/fate. In Encyclopedia of the Eye Joseph C. Besharse, Reza Dana, and Darlene A. Dartt (eds.). Vol 2. Amsterdam: Elsevier/Academic, 2010. 

Hufnagel, RB and Brown, NL. Specification of Retinal Cell Types in Comprehensive Developmental Neuroscience John Rubenstein and Pasko Rakic (eds). Elsevier/Academic In Press.