Sandip Bhattacharyya, MSc, PhD

Assistant Professor, UC Department of Pediatrics

Center for the Prevention of Preterm Birth

Phone 513-803-8039

Email sandip.bhattacharyya@cchmc.org

Inflammation Immunology; Signal Transduction

Dr. Bhattacharyya received his doctoral degree in immunology and cell biology from Jadavpur University, India. His doctoral research shed light on multi-level regulation of host immune responses in experimental visceral leishmaniasis. During his post-doctoral training at the University of North Carolina, Chapel Hill, Dr. Bhattacharyya explored critical roles of Interleukin-10 for regulation of Nuclear Factor Kappa B signaling pathway in dendritic cells. Later, at Washington University, St Louis and Vanderbilt University, Nashville, Dr. Bhattacharyya uncovered new mechanisms for glucocorticoid actions on Toll-like receptor-induced inflammatory pathways. His findings provided evidence for signal-dependent glucocorticoid sensitivity.  Dr. Bhattacharyya’s study indicated that the spectrum of TLRs activated determines their responsiveness to steroid therapy.

Dr. Bhattacharyya was selected for the Ramanujan Fellowship, 2011, awarded by the Department of Science and Technology, Government of India.

BSc: Chemistry, University of Calcutta, Calcutta, India.

MSc: Biochemistry, University of Calcutta, Calcutta, India.

PhD: Cell Biology and Immunology, Jadavpur University, Calcutta, India.

Post Doctoral Fellowship: University of North Carolina, Chapel Hill, NC.

Senior Scientist: Washington University, Saint Louis, MO / Vanderbilt University, Nashville, TN.

Ratajczak C.K., Asada M, Allen, G.C., McMahon, D.G., Muglia, L.M., Smith, D., Bhattacharyya, S., and Muglia, L.J. Generation of myometrium-specific Bmal1 knockout mice for parturition analysis. Reproduction, Fertility and Development. 2012;24(5):759-67.

Bhattacharyya S, Kay T, Zhao Z, Muglia LJ. Glucocorticoids Target suppressor of cytokine synthesis 1 (SOCS1) and Type 1 Interferons to Regulate Toll-like Receptor-induced STAT1 Activation. Proc Natl Acad Sci USA. 2011;108(23):9554-9559.

Bhattacharyya, S, Ratajczak CK, Vogt SE, Kelley C, Colonna M, Schreiber RD. Muglia, LJ. TAK1 Targeting by Glucocorticoids Determines JNK and IkB Regulation in Toll-like Receptor-Stimulated Macrophages. Blood. 2010;115(10):1921-1931.

Kim HJ, Zhao H, Kitaura H, Bhattacharyya S, Brewer JA, Muglia LJ, Ross FP, Teitelbaum SL. Glucocorticoids and the osteoclast. Ann N Y Acad Sci. 2007;1116:335-339.

Bhattacharyya S, Brown DE, Brewer JA, Vogt SE, Muglia LJ. Glucocorticoid receptor regulates toll-like receptor-4 mediated inflammatory responses by inhibition of p38 MAP kinase. Blood. 2007;109(10):4313-4319.

Kim HJ, Zhao H, Kitaura H, Bhattacharyya S, Brewer JA, Muglia LJ, Ross FP, Teitelbaum SL. Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest. 2006;116(8):2152-2160.

Bhattacharyya S, Sen P, Wallet M, Long B, Baldwin AS Jr., Tisch R. Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood. 2004;104(4):1100-1109.

Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M, Baldwin AS, Jr.,  Tisch, R. NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol. 2003;170(4):1770-1780.

Bhattacharyya S, Ghosh S, Dasgupta B, Mazumder D, Roy S, Majumdar S. Chemokine-induced leishmanicidal activity in murine macrophages via the generation of nitric oxide. J Infect Dis. 2002;185(12):1704-1708.

Bhattacharyya S, Ghosh S, Jhonson PL, Bhattacharya SK, and Majumdar S. Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events. Infect Immun. 2001;69(3):1499-1507.