Dr. Boyce is an expert in the development of human cell culture systems, wound healing, burn physiology, biocompatability of implantable materials, microscopy, and quantitative biochemical techniques. He is interested in mechanisms of wound healing with cultured human skin, skin regeneration with cultured cells and biopolymers, treatment of chronic wounds, control of infection, proopiomelanocortin and its peptides in human epidermis, and dermal irritation. Dr. Boyce's work has developed culture systems for skin substitutes that are used to treat burn wounds as a significant improvement to traditional split thickness skin grafting procedures. He characterized these cultures and the living skin substitute with noninvasive biophysical techniques, and is working to understand the formation of hyperpigmentation during skin grafting. Dr. Boyce's expertise in skin restoration and his focus on research applications are critical cornerstones of the Skin Sciences Institute.