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Biographies

Find another Doctor or Researcher

High Res

Chieh Chang, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-0945

Email: chieh.chang@cchmc.org

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Specialties

understanding how neurons connect with each other to form functional neural circuits; how neurons regenerate and repair themselves after injury; how age influences the intrinsic axon growth ability

Visit the Chang Lab web page.

Biography

2008-present Head, Laboratory of Assembly and Regeneration of Neuronal Circuits, Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation

2006-2008 Assistant Professor of Biology, Associate member of Neurology and Neurosurgery, McGill University, Montreal, Canada

2001-2006 Postdoctoral Fellow with Marc Tessier-Lavigne at the Howard Hughes Medical Institute, Stanford University and with Cornelia I. Bargmann at the Howard Hughes Medical Institute, University of California, San Francisco & Rockefeller University

1995-2001 Doctoral research with Paul W. Sternberg at the Howard Hughes Medical Institute, California Institute of Technology

Education and Training

Postdoctoral Fellowship: Rockefeller University, University of California San Francisco, and Stanford University

PhD: California Institute of Technology

Publications

View PubMed Publications

Chiu H, Alqadah A, Chuang C-F, Chang, C. C. elegans as a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration.Cell Adhesion & Migration 2011; 5: 387-394.

Chang C, Hsieh Y-W, Lesch BJ, Bargmann CI, Chuang C-F. Microtubule-based localization of a synaptic calcium signaling complex is required for left-right neuronal asymmetry in C. elegans. Development. 138: 3509-3518. 2011.

Gabel CV, Antoine F, Chuang CF, Samuel ADT, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development. 2008;135:1129-36.

Samuel ADT, Chung SH, Clark DA, Gabel CV, Chang C, Murthy V, Mazur E. Femtosecond laser dissection in C. elegans neural circuits. Proceedings of the International Society for Optical Engineering. 2006;6108:6108011-16.

Chang C, Adler C, Krause M, Clark S, Hao J, Gertler F, Tessier-Lavigne M, Bargmann CI. MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and Netrin. Current Biology. 2006;16:854-62.

Chang C, Yu TW, Bargmann CI, Tessier-Lavigne M. Inhibition of Netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science. 2004;305:103-6.

Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis, and metastasis. Trends in Cell Biology. 2001;11:S37-43.

Yoon CH*, Chang C*, Hopper NA*, Lesa GM, Sternberg PW. Requirements of multidomains of SLI-1, a C. elegans homolog of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation. Molecular Biology of the Cell. 2000;11:4019-31.

Chang C, Hopper NA, Sternberg PW. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO Journal. 2000;19:3283-94.

Chang C, Sternberg PW. C. elegans vulval development as a model system to study the cancer biology of EGFR signaling. Cancer and Metastasis Reviews. 1999;18:203-13.

Chang C, Newman AP, Sternberg PW. Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia. Current Biology. 1999;9:237-46.

Hsieh J, Liu J, Kostas SA, Chang C, Sternberg PW, Fire A. The RING finger/B-box factor TAM-1 and a retinoblastoma-like proteins LIN-35 modulate context-dependent gene silencing in C. elegans. Genes & Development. 1999;13:2958-70.

Bogarad LD, Arnone MI, Chang C, Davidson EH. Interference with gene regulation in living sea urchin embryos: transcription factor knock out (TKO), a genetically controlled vector for blockade of specific transcription factors. Proc National Academy of Sciences USA. 95(25):14827-32. 1998.