understanding how neurons connect with each other to form functional neural circuits; how neurons regenerate and repair themselves after injury; how age influences the intrinsic axon growth ability

Visit the Chang Lab web page.

Postdoctoral Fellowship: Rockefeller University, University of California San Francisco, and Stanford University

PhD: California Institute of Technology

Zou Y^†, Chiu H^†, Zinovyeva A, Ambros V, Chuang C-F*, Chang C*.  Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science  ^†Equal contribution  *Senior authors contributed equally. In Press. 2013.

Schumacher JA, Hsieh Y-W, Chen S, Pirri JK, Alkema MJ, Li W-H, Chang C*, Chuang C-F*. Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans. Development, 139, 4191-4201. 2012.

Hsieh Y-W, Chang C*, Chuang C-F*. The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans.  PLoS Genetics 8(8): research article e1002864. Aug 2. 2012. *Senior Authors contributed equally.

Zou Y, Chiu H, Domenger D, Chuang C-F, Chang C. The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction. Science Signaling 5, research article ra43, 2012.

Chiu H, Alqadah  A, Chuang C-F, Chang, C. C. elegansas a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration. Cell Adhesion & Migration 2011; 5: 387-394.

Chang C, Hsieh Y-W, Lesch BJ, Bargmann CI, Chuang C-F. Microtubule-based localization of a synaptic calcium signaling complex is required for left-right neuronal asymmetry in C. elegans. Development. 138: 3509-3518. 2011.

Gabel CV, Antoine F, Chuang CF, Samuel ADT, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development. 2008;135:1129-36. 

Samuel ADT, Chung SH, Clark DA, Gabel CV, Chang C, Murthy V, Mazur E.Femtosecond laser dissection in C. elegans neural circuits.Proceedings of the International Society for Optical Engineering. 2006;6108:6108011-16.

Chang C, Adler C, Krause M, Clark S, Hao J, Gertler F, Tessier-Lavigne M, Bargmann CI. MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and Netrin. Current Biology. 2006;16:854-62.

Chang C, Yu TW, Bargmann CI, Tessier-Lavigne M. Inhibition of Netrin-mediated axon attraction by a receptor protein tyrosine phosphatase.Science. 2004;305:103-6.

Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis, and metastasis.Trends in Cell Biology. 2001;11:S37-43.

Yoon CH*, Chang C*, Hopper NA*, Lesa GM, Sternberg PW. Requirements of multidomains of SLI-1, a C. elegans homolog of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.Molecular Biology of the Cell. 2000;11:4019-31.

Chang C, Hopper NA, Sternberg PW. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO Journal. 2000;19:3283-94.

Chang C, Sternberg PW. C. elegans vulval development as a model system to study the cancer biology of EGFR signaling.Cancer and Metastasis Reviews. 1999;18:203-13.

Chang C, Newman AP, Sternberg PW. Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia. Current Biology. 1999;9:237-46.

Hsieh J, Liu J, Kostas SA, Chang C, Sternberg PW, Fire A. The RING finger/B-box factor TAM-1 and a retinoblastoma-like proteins LIN-35 modulate context-dependent gene silencing in C. elegans.Genes & Development. 1999;13:2958-70.

Bogarad LD, Arnone MI, Chang C, Davidson EH. Interference with gene regulation in living sea urchin embryos: transcription factor knock out (TKO), a genetically controlled vector for blockade of specific transcription factors. Proc National Academy of Sciences USA. 95(25):14827-32. 1998.