David S. Cooper, MD, MPH

Chief Safety Officer, Heart Institute

Associate Medical Director, Cardiovascular Intensive Care Unit

Co-Director, Center for Acute Care Nephrology

Medical Director, Cardiac Extracorporeal Life Support Program

Associate Professor, UC Department of Pediatrics


Pediatric cardiac critical care; patient safety; extracorporeal life support


Acute/chronic kidney injury; anticoagulation on extracorporeal support; abnormal sleep patterns in patients with congenital heart disease; antibiotic Stewardship in the CVICU; correlation of Near Infrared Spectroscopy (NIRS) and outcome in the cardiovascular intensive care unit; quality and outcomes in the CICU 

Dr. Cooper is board certified in Pediatrics, Pediatric Cardiology and Pediatric Critical Care. He is currently the Heart Institute Safety Officer, Co-Director of the Center for Acute Care Nephrology, Director of the Cardiac ECMO Program and Associate Medical Director of the CICU at Cincinnati Children’s Hospital Medical Center.

Dr. Cooper's career over the past 10 years has focused on the care of critically ill neonates, infants, children, adolescents and adults with complex congenital heart disease (CHD). He has a particular interest in how care in the intensive care unit can impact morbidity with a specific interest in hematologic, infectious and renal morbidities. Additionally, Dr. Cooper has had extensive involvement with the Pediatric Cardiac Critical Care Consortium (PC4), including the development of the PC4 CICU database that will be used to track outcomes and improve outcomes for patients with critical cardiac disease.

MD: University of South Florida College of Medicine, Tampa, Florida, 1996.

MPH: University of South Florida College of Public Health, Tampa, Florida, 1999.

Residency: All Children’s Hospital, University of South Florida, St. Petersburg, FL.

Fellowships: Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Critical Care, Children’s Medical Center Dallas, UT Southwestern, Dallas, Texas.

Certifications: American Board of Pediatrics; American Board of Pediatrics, Sub-board of Pediatric Cardiology; American Board of Pediatrics, Sub-board of Pediatric Critical Care.

View PubMed Publications

DeSena HC, Nelson DP, Cooper DS. Cardiac Intensive Care for the Neonate and Child After Cardiac Surgery. Current Opinion in Cardiology. 2015 Jan;30(1):81-8.

Kwiatkowski DM, Menon S, Krawczeski CD, Goldstein SL, Morales DL, Philips A, Manning PB, Eghtesady P, Wang Y, Nelson DP, Cooper DS. Improved Outcomes with Peritoneal Dialysis Catheter Placement after Cardiopulmonary Bypass in Infants. Journal of Thoracic and Cardiovascular Surgery. 2015 Jan;149(1):230-6.

Gaies M, Cooper DS, Tabbutt S, Schwartz SM, Ghanayem N, Chanani NK, Costello JM, Thiagarajan RR, Laussen PC, Shekerdemian LS, Donohue JE, Willis GM, Gaynor JW, Jacobs JP, Ohye RG, Charpie JR, Pasquali SK, Scheurer MA. Collaborative quality improvement in the cardiac intensive care unit: development of the Paediatric Cardiac Critical Care Consortium (PC4). Cardiol Young. 2014 Aug;28:1-7.

Jolley M, Thiagarajan R, Salvin J, Barrett C, Cooper DS, Teele S. ECMO in Patients with Superior Cavopulmonary Anastomosis (Glenn). Journal of Thoracic and Cardiovascular Surgery. 2014;148(4):1512-8.

Costello JM, Pasquali SK, He X, Jacobs JP, Hill KD, Cooper DS, Baker CL, Jacobs ML. Gestational Age at Birth and Outcomes after Neonatal Cardiac Surgery: An Analysis of the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database. Circulation. 2014;129:2511-2517.

Tabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, Frank DU, Lu M, Pizarro C, Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L, Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P, Pediatric Heart Network Investigators. Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg. 2012 Oct;144(4):882-95.

Ghanayem NS, Allen KR, Tabbutt S, Atz AM, Clabby ML, Cooper DS, Eghtesady P, Frommelt PC, Gruber PJ, Hill KD, Kaltman JR, Laussen PC, Lewis AB, Lurito KJ, Minich LL, Ohye RG, Schonbeck JV, Schwartz SM, Singh RK, Goldberg CS, Pediatric Heart Network Investigators. Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg. 2012 Oct;144(4):896-906.

Cooper DS, Charpie JR, Flores FX, Gaynor JW, Salvin JW, Devarajan P, Krawczeski CD. Acute kidney injury and critical cardiac disease. World J Ped Congen Heart Surg. 2011;2:411-423.

Jacobs JP, Asante-Korang A, O'Brien SM, Chai PJ, Dadlani GH, Rodriguez-Fazzi GL, Vu D, McCormack J, McKenna DE, Boucek RJ Jr, Cooper DS, Saltiel A, Carapellucci J, van Gelder HM, Daicoff GR, Quintessenza JA. Lessons learned from 119 consecutive cardiac transplants for pediatric and congenital heart disease. Ann Thorac Surg. 2011 Apr;91(4):1248-54.

Pilchard J, Dadlani G, Andropoulos D, Jacobs JP and Cooper DS. Intensive care and perioperative management of patients with complete atrioventricular septal defect. World J Ped Congen Heart Surg. 2010 Apr;1:105-111.

Evaluation of the Pharmacokinetics of ATIII in Neonates and Infants Undergoing CPB and ECMO Support. Principal Investigator. Grifols. 2014-present.

A Randomized, Placebo Controlled, Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Intravenous (IV) Acetaminophen for the Treatment of Acute Pain in Pediatric Patients. Site Principal Investigator. Cadence. 2014-present.

Use of acute kidney injury biomarkers to predict impaired milrinone pharmacokinetics in children. Mentor. Thrasher grant. 2013-present.

Extracorporeal Life Support Organization (ELSO) Research Grant. Principal Investigator. Extracorporeal Life Support Organization. 2012-present.