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High Res

Mitchell B. Cohen, MD

Vice-Chair of Pediatrics for Clinical Affairs

Director, Division of Gastroenterology, Hepatology & Nutrition

Professor, UC Department of Pediatrics

Professor, Associate Professor, Internal Medicine

Phone: 513-636-3008

Fax: 513-636-5581

Email: mitchell.cohen@cchmc.org

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Specialties

Clinical Interests

Diarrheal disorders; inflammatory bowel disease; celiac disease

Research Interests

Intestinal secretion; diarrheal disease; developmental biology

Visit the Cohen-Steinbrecher Lab.

Biography

Mitchell B. Cohen, MD, completed his pediatric training at Johns Hopkins Hospital and entered the public health service where he served at the Keams Canyon Indian Hospital on the Hopi Reservation in northeast Arizona. Subsequently, he completed a pediatric gastroenterology and nutrition fellowship at Cincinnati Children's Hospital Medical Center.

Dr. Cohen has had a long-standing interest in the pathophysiology of diarrheal diseases and continues to direct basic science and clinical research programs related to intestinal secretion and infection. These programs include studies of the guanylin family of intestinal peptides, epidemiology and pathogenesis of diarrheagenic E. coli and studies of human cholera and typhoid fever vaccines.

Dr. Cohen is the director of Gastroenterology, Hepatology & Nutrition at Cincinnati Children's. He is also vice-chair of Pediatrics for Clinical Affairs, associate director of the NIDDK-funded Silvio O. Conte Digestive Diseases Research Core Centers (DDRCC) entitled Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease and the director of the NIH-funded Fellowship Training Program in Pediatric Gastroenterology.

Dr. Cohen has served as president of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and chair of the section on Growth Development and Aging of the American Gastroenterological Association. He is a member of the Clinical Research Committee of the Cystic Fibrosis Foundation (CFFTI), and has served as permanent and ad hoc member on a number of NIH study sections and the National Commission on Digestive Diseases.

Education and Training

MD: Mount Sinai School of Medicine, New York, NY, 1977.

Residency: Johns Hopkins Hospital, Baltimore, MD, 1977 to 1980.

Fellowship: Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center of Cincinnati, 1983 to 1986; Research Scholar, Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center of Cincinnati, 1986 to 1987.

Certification: Pediatrics, 1981; Pediatric Gastroenterology and Nutrition, 1990, 1997, 2004.

Publications

View PubMed Publications

Steinbrecher KA, Cohen MB. Transmembrane guanylate cyclase in intestinal pathophysiology. Curr Opin Gastroenterol. 2010 Nov 20.

Mann EA, Shanmukhappa K, Cohen MB. Lack of guanylate cyclase C results in increased mortality in mice following liver injury. BMC Gastroenterol. 2010 Aug 2;10:86.

Graham RC, Heubi JE, Cohen MB, Li B. Teaching and tomorrow: a novel recruitment program for a pediatric subspecialty. J Pediatr Gastroenterol Nutr. 2009 Nov;49(5):594-8.

Cohen MB. Clostridium difficile infections: emerging epidemiology and new treatments. J Pediatr Gastroenterol Nutr. 2009 Apr;48 Suppl 2:S63-5.

Garin-Laflam MP, Steinbrecher KA, Rudolph JA, Mao J, Cohen MB. Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G740-9.

Cohen MB, Gunter JB. How safe is intravenous sedation with midazolam and fentanyl for pediatric gastrointestinal endoscopy? Nat Clin Pract Gastroenterol Hepatol. 2007 Oct;4(10):538-9. Epub 2007 Aug 21.

Pasternak B, Grom A, Yazigi N, Cohen MB. Suppurative peripheral arthritis in inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):117-20. No abstract available.

Rudolph JA, Pratt J, Mourya R, Steinbrecher KA, Cohen MB. Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell line. Cell Signal. 2007 Jun;19(6):1221-8.

Burrow TA, Cohen MB, Bokulic R, Deutsch G, Choudhary A, Falcone RA Jr, Grabowski GA. Gaucher disease: progressive mesenteric and mediastinal lymphadenopathy despite enzyme therapy. J Pediatr. 2007 Feb;150(2):202-6.

Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier BK, Akers R, Cohen MB, Collins MH, Assa'ad AH, Aceves SS, Putnam PE, Rothenberg ME. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology. 2006 Nov;131(5):1381-91.

Grants

Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease. Program Director; Director, Administrative Core. National Institutes of Health. Aug 2007 - May 2012. #P30 DK 0789392.

Evaluation of control measures against human infectious diseases other than AIDS. Co-Investigator. National Institute of Allergy and Infectious Diseases. Nov 2007 - Oct 2012. #N01-AI25459.