About
BA: Biology and Psychology, Washington University, St. Louis, Missouri, 1983.
PhD: Microbiology, Louisiana State University, Baton Rouge, Louisiana, 1989.
Interests
The research focus of the Cardin Lab is to understand the virus-host interactions that are important for CMV pathogenesis and immunological control of long term latent CMV infection. CMV encodes viral homologs to host proteins (such as IL-10, TNF, chemokine receptors) that interfere with the host immune response by immune evasion or by mimicry. Understanding the advantages provided by 'hijacking' of host proteins by CMV will lead to the development of effective vaccine strategies.
Publications
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. Vaccine. 2016; 34(17):1993-1999.
Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs. Antiviral Chemistry and Chemotherapy. 2015; 24(1):19-27.
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes. Science Translational Medicine. 2014; 6(265):265ra169.
Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes. Antiviral Chemistry and Chemotherapy. 2014; 23(5):189-196.
An adjuvanted herpes simplex virus 2 subunit vaccine elicits a T cell response in mice and is an effective therapeutic vaccine in Guinea pigs. Journal of Virology. 2013; 87(7):3930-3942.
Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model. Journal of Virology. 2013; 87(7):4112-4117.
CMV infection attenuates the disease course in a murine model of multiple sclerosis. PLoS ONE. 2012; 7(2):e32767.
N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs. Antiviral Research. 2011; 92(2):386-388.
Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues. Journal of Virology. 2011; 85(12):6091-6095.
Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig. Vaccine. 2011; 29(11):2071-2078.
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026
© 1999-2025 Cincinnati Children's Hospital Medical Center. All rights reserved.
