The research focus of the Cardin lab is to understand the virus-host interactions that are important for CMV pathogenesis and immunological control of long term latent CMV infection. CMV encodes viral homologs to host proteins (such as IL-10, TNF, chemokine receptors) that interfere with the host immune response by immune evasion or by mimicry. Understanding the advantages provided by 'hijacking' of host proteins by CMV will lead to the development of effective vaccine strategies.
Education and Training
BA: Biology and Psychology, Washington University, St. Louis, Missouri, 1983.
PhD: Microbiology, Louisiana State University, Baton Rouge, Louisiana, 1989.
View PubMed Publications
Bravo FJ, Bernstein DI, Beadle JR, Hostetler KY, Cardin RD. Oral Hexadecyloxypropyl-Cidofovir (HDP-CDV) Therapy of Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection. Antimicrob Agents Chemother. 2010 Nov 15. [Epub ahead of print]
Farley N, Bernstein DI, Bravo FJ, Earwood J, Sawtell N, Cardin RD. Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy. Antiviral Res. 2010 May;86(2):188-95. Epub 2010 Feb 16.
Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A. Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection. Virol J. 2009 Dec 2;6:214.
Cardin RD, Schaefer GC, Allen JR, Davis-Poynter NJ, Farrell HE. The M33 chemokine receptor homolog of murine cytomegalovirus exhibits a differential tissue-specific role during in vivo replication and latency. J Virol. 2009 Aug;83(15):7590-601. Epub 2009 May 13.
Bernstein DI, Cardin RD, Bravo FJ, Strasser JE, Farley N, Chalk C, Lay M, Fairman J. Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines. Clin Vaccine Immunol. 2009 May;16(5):699-705. Epub 2009 Mar 11.
Bravo FJ, Cardin RD, Bernstein DI. A model of human cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 2007 Nov;76(2):104-10. Epub 2007 Jul 10.
Bravo FJ, Cardin RD, Bernstein DI. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2006 Feb 15;193(4):591-7. Epub 2006 Jan 13.