Tiffany Cook, PhD

Associate Professor, UC Department of Pediatrics

Phone 513-636-6991

Fax 513-803-0740

Email tiffany.cook@cchmc.org

Understanding the molecular basis of eye development; differentiation of color photoreceptor subtypes in the Drosophila retina; cell-specific regulation of opsin gene expression; mechanisms of cell-specific transcriptional activation and repression

Differentiation of color photoreceptor subtypes in the Drosophila retina; cell-specific regulation of opsin gene expression; mechanisms of cell-specific transcriptional activation and repression

Visit the Cook Lab.

BA: Biology, Summa Cum Laude, Phi Beta Kappa, 1987-1991. 

PhD: Biomedical Sciences/Molecular Biology, 1991-1997. 

Postdoctoral fellowships: Gastroenterology, 1997-1999; Molecular Genetics, 1999-2004.

Jukam D, Xie B, Rister J, Terrell D, Charlton-Perkins M, Pistillo D, Gebelein B, Desplan C, Cook T. Opposite network-level feedback in the Hippo pathway for growth regulation and post-mitotic neural fate. Science 2013 Aug 29. [Epub ahead of print]

Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet. 44:1265-71, 2012.

Terrell D, Xie B, Workman M, Mahato S, Zelhof A, Gebelein B, Cook T. OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eyeDev Dyn. 2012;241(1):215-28.

Charlton-Perkins M, Brown NL, Cook T. Lens in focus: A comparison of lens development in Drosophila and vertebratesMolec Genet Genom. 2011;286(3-4):189-213.

Charlton-Perkins M, Whitaker SL, Fei Y, Xie B, Li-Kroeger D, Gebelein B, Cook T. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating EGF and Notch-dependent signalingNeural Dev. 2011;6(1):20.

Cook T, Zelhof A, Mishra M, Nie J. 800 Facets of Retinal Degeneration. Prog Mol Biol Transl Sci 2011;100:331-68.

Charlton-Perkins M, Cook TA. Building a Fly Eye:  Terminal Differentiation Events of the Retina, Corneal Lens, and Pigmented EpitheliaCurr Top Dev Biol. 2010;93:129-73.

McDonald EC, Xie B, Workman M, Charlton-Perkins M, Terrell DA, Reischl J, Wimmer E, Gebelein B, Cook TA. Multiple transcriptional regulatory domains within Otd control photoreceptor differentiation. Dev Biol. 2010;347:122-32.

Mishra M, Oke A, Lebel C, McDonald EC, Plummer Z, Cook TA, and Zelhof AC. Pph13 and Orthodenticle define a dual regulatory pathway for Drosophila photoreceptor cell morphogenesis and function. Development. 2010;137:2895-904.

Xie B, Charlton-Perkins M, McDonald EC, Gebelein B, Cook TA. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development. 2007;134:4243-4253.