Weiguo Chen, MD, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4752

Fax: 513-636-1657


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Asthma; allergy and immunology


Dr. Chen received his MB degree in clinical medicine and an MS degree in biochemistry at Shanghai Medical University. In 2000, he received his PhD degree in cell and molecular biology at the University of Cincinnati. After completing his postdoctoral training at the University of California, Berkeley, he joined Cincinnati Children’s in 2001.

Dr. Chen is a molecular biologist with research interests in molecular mechanisms of asthma pathogenesis. Over the past few years, Dr. Chen’s research focus shifted to studying epigenetic regulation of gene expression in allergic asthma, especially the enzymes involved in nitric oxide metabolism and oxidative stress, and seeking novel pharmacological therapies for asthma. His current studies include (1) Role of dimethylarginine dimethylaminohydrolases in the development of allergic asthma; (2) Epigenetic regulation of dimethylarginine dimethylaminohydrolases; and (3) Therapeutic effect of farnesoid X receptor agonists in allergic asthma.

Dr. Chen has been actively conducting research on regulation of signaling pathways in the development of allergic asthma. He is a co-investigator on a project studying the biological functions of interleukin-13 receptors, demonstrating a distinct role of interleukin-13 receptor alpha 2 in the pathogenesis of allergic asthma.  Dr. Chen is collaborating with other investigators from the Department of Environmental Health at the University of Cincinnati, Center for Autoimmune Genomics and Etiology, and Pyrosequencing Core Laboratory for Genomic and Epigenomic Research at Cincinnati Children’s to study the role of RNA editing in the development of allergic asthma as allergen exposure has been shown to alter RNA editing in lung tissues in experimental asthma.

Dr. Chen’s long-term career goals are to advance his understanding of the molecular basis for asthma and help find a cure for asthma. 

Education and Training

MD: Shanghai Medical University, China, 1985.

MS: Biochemistry, Shanghai Medical University, China, 1990.

PhD: Cell and Molecular Biology, University of Cincinnati, OH, 2000.

Postdoctoral: University of California at Berkeley, Berkeley, CA, 2000-2001; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2001-2008.


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