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High Res

Sudhansu K. Dey, PhD

Lova Riekert Chair and Professor of Pediatrics, Cancer and Cell Biology

Director, Division of Reproductive Sciences

Professor, UC Department of Pediatrics

Phone: 513-803-1158

Fax: 513-803-1160

Email: sk.dey@cchmc.org

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Specialties

Prostaglandin-nuclear receptor-angiogenic signaling axis during embryo implantation with special emphasis to cPLA2α-Cox2-PPARδ-Vegf network in the uterus; cytokine-growth factor-homeobox-morphogen signaling axis in implantation involving Lif-Hb-Egf-Hoxa10/Msx1-Ihh/Bmp/Wnt network in the uterus; immunophilin/cochaperone-nuclear signaling in the mouse uterus during implantation involving Fkbp52-PR; ligand-receptor signaling with endocannabinoids during the periimplantation events in mice in the context of anandamide interacting with G-protein coupled receptors, CB1 and CB2; molecular and genetic basis of epithelial ovarian cancer with special reference to prostaglandin-PPAR signaling; miRNA and Cox-2 regulation in uterine biology and cancer; Pten and uterine carcinoma: conditionally gene deleted mouse models

Visit the Dey Lab.

Biography

Dr. Dey received his PhD from Calcutta University in 1972, after which he obtained postdoctoral training at Kansas University Medical Center from 1973-1977, followed by his faculty appointment in 1977 where he rose to the rank of University Distinguished Professor. He moved to Vanderbilt University as Dorothy Overall Wells Professor of Pediatrics, Cell & Dev Biology and Pharmacology in 2002. In both places, he directed NIH-funded reproductive biology training grants. In 2008, Dr. Dey moved to Cincinnati Children’s Hospital Medical Center as Lova Riekert Chair and Professor of Pediatrics to start a new Division of Reproductive Sciences. He has published over 250 original articles and is funded by two MERIT Awards and a Program Project Grant from NIH. His research mission has been to define the molecular road map to embryo-uterine interactions during pregnancy. His recent work published in Nat Med and JCI provides novel information in the context of ectopic pregnancy and progesterone resistance to pregnancy failure. In 2008, Dr. Dey received Carl G. Hartman Award, the highest honor of the Society for the Study of Reproduction.

He has graduated 5 PhD students, and mentored 35 postdoctoral students, 20 of whom are currently independent faculty members, and most others are investigators in major research institutions. His laboratory currently consists of 4 postdoctoral fellows, 1 graduate student, 1 MD/PhD student, 1 visiting graduate student and two research assistants.

Education and Training

BSc: University of Calcutta, India, 1965.

MSc: University of Calcutta, India, 1967.

PhD: University of Calcutta, India, 1972.

Publications

View PubMed Publications

Sun X, Xie H, Yang J, Wang H, Bradshaw HB, Dey SK. Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16887-92.

Hirota Y, Acar N, Tranguch S, Burnum KE, Xie H, Kodama A, Osuga Y, Ustunel I, Friedman DB, Caprioli RM, Daikoku T, Dey SK. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15577-82.

Hirota Y, Cha J, Dey SK. Revisiting reproduction: Prematurity and the puzzle of progesterone resistance. Nat Med. 2010 May;16(5):529-31.

Dey SK. How we are born. J Clin Invest. 2010 Apr 1;120(4):952-5.

Hirota Y, Daikoku T, Tranguch S, Xie H, Bradshaw HB, Dey SK. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest. 2010 Mar 1;120(3):803-15.

Sun X, Jackson L, Dey SK, Daikoku T. In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus. Endocrinology. 2009 Nov;150(11):5065-73.

Sun X, Dey SK. Cannabinoid/Endocannabinoid signaling impact on early pregnancy events. Curr Top Behav Neurosci. 2009;1:255-73. Review.

Burnum KE, Cornett DS, Puolitaival SM, Milne SB, Myers DS, Tranguch S, Brown HA, Dey SK, RM Caprioli. Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J Lipid Res. (2009).

Daling JR, Doody DR, Sun X, Trabert BL, Weiss NS, Chen C, Biggs ML, Starr JR, Dey SK, SM Schwartz. Association of marijuana use and the incidence of testicular germ cell tumors. Cancer. 2009 115(6):1215-23.

Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, C Chiang. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 2009.