Lesley A. Doughty, MD

Physician, Division of Critical Care Medicine

Associate Professor, UC Department of Pediatrics

Phone 513-636-4259

Fax 513-636-4267

Email lesley.doughty@cchmc.org

Sepsis; multiple organ failure; viral immunomodulation
MD: Dartmouth Medical School.

Residency: Tripler Army Medical Center.

Fellowship: Children's Hospital of Pittsburgh.
Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatr Crit Care Med. 2011 Jan;12(1):120-121.

Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010 Oct;38(10):1955-61.

Giuliano JS Jr, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock. 2007 Dec;28(6):650-654.

Wheeler DS, Lahni P, Odoms K, Jacobs BR, Carcillo JA, Doughty LA, Wong HR. Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock. Inflamm Res. 2007 May;56(5):216-9.

Han YY, Doughty LA, Kofos D, Sasser H, Carcillo JA. Persistently Increased Procalcitonin Is Associated with Poor Outcome among Children with Bacterial Sepsis. Crit Care Med. 2003;4:21-25.

Ayala A, Chung CS, Lomas J, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski P. Shock Induced Neutrophil Mediated Priming for Acute Lung Injury in Mice: Divergent Effects of TLR 4 and TLR 4 / FasL Deficiency. AJP. 2003;161:2283-2294.

Lomas JL, Chung CS, Grutkoski pS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A. Differential Effects of MIP-2 and KC on Hemorrhage Induced Neutrophil Priming for Lung Inflammation: Assessment by Adoptive Cells. Shock. 2003;19(4):358-365.

Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ. Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Medicine. 2003;29:980-984.

Durbin J, Doughty L, Nguyen K, Caliguri M, Van Deusen J, Biron C. The role of STAT1 in viral sensitization to LPS. J Endotoxin Res. 2003;9:313-316.

Doughty LA. Modulation of the immune response in critical illness / injury. Immunology and Infectious Disease. Eds. Doughty L. and Linden P. Kluwer Academic Publishers, Norwell, MA, 2003.