Sandra J.F. Degen, PhD

Associate Chair for Academic Affairs

Vice President for Research, University of Cincinnati

Professor, UC Department of Pediatrics

Phone 513-636-4816

Fax 513-636-4317

Email sandra.degen@cchmc.org

Regulation of expression of proteins in blood coagulation and growth control: prothrombin; hepatocyte growth factor-like protein (HGFL) and its membrane tyrosine kinase receptor (Ron)

Sandra J. F. Degen, PhD, received her BA degree in chemistry from the University of California, San Diego in 1976 and her PhD degree in biochemistry from the University of Washington in 1982.

Following a two year post-doctoral fellowship at the Friedrich Miescher Institute in Basel, Switzerland, she was appointed as an assistant professor of pediatrics at the University of Cincinnati in 1985. She is presently a tenured professor of pediatrics.

The research in Dr. Degen's laboratory focused on two areas of interest that includes blood coagulation and cancer research. Dr. Degen has three patents in this area. Dr. Degen has had continuous grant support since she received her first academic position, and until 2006 was principal investigator on two National Institutes of Health (NIH) grants.

Dr. Degen's honors and awards include being selected as a pew scholar in the biomedical sciences supported by the Pew Memorial Trust, being awarded an Established Investigatorship from the American Heart Association, serving as a regular member of the Hematology II study section at the NIH and being selected to attend the Executive Leadership in Academic Medicine Program for Women in 1997. Most recently she was selected to participate in the Science and Society Institute sponsored by the Pew Scholars Program.

For the University of Cincinnati, she is responsible for all research compliance activities, the animal research program, sponsored research services, sponsored program accounting, entrepreneurial affairs, the intellectual property office, research educational programs and regional, state and federal advocacy with regard to research. More information can be found at the web site for the Office of Research.

Dr. Degen serves on the board of directors of Bio/Start, the Ohio Aerospace Institute, TechSolve and the Oak Ridge Associated Universities.

BA: University of California, San Diego, 1976.

PhD: University of Washington, Seattle, WA, 1982.

Fellowship: Post-doctoral fellowship at the University of Washington in Seattle, WA, 1982-83; post-doctoral Fellowship at the Friedrich Meischer Institute in Basel, Switzerland, 1983-1985.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood. 2009 Jan 15;113(3):696-704.

Wetzel CC, Leonis MA, Dent A, Olson MA, Longmeier AM, Ney PA, Boivin GP, Kader SA, Caldwell CC, Degen SJ, Waltz SE.  Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G253-61. 

Kahn JA, Degen SJ, Mansour ME, Goodman E, Zeller MH, Laor T, Lanphear NE, Boat TF. Pediatric faculty members' attitudes about part-time faculty positions and policies to support part-time faculty: a study at one medical center. Acad Med. 2005 Oct;80(10):931-9.

Wu J, Wang Y, Xiao W, Meyer KB, Schmidt KM, Morris RE, Degen SJ, La Barbera AR. Assessment of recombinant porcine follicle-stimulating hormone receptor using a novel polyclonal ectodomain antibody. Endocr Res. 2004 May;30(2):269-85.

Hess KA, Waltz SE, Toney-Earley K, Degen SJThe receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulationFertil Steril. 2003 Sep;80 Suppl 2:747-54.

Peace BE, Hill KJ, Degen SJ, Waltz SE. Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. Exp Cell Res. 2003 Oct 1;289(2):317-25.

Wetzel CC, Degen SJ, Waltz SE. Cis-acting elements in the hepatocyte growth factor-like protein gene regulate kidney and liver-specific expression in mice. DNA Cell Biol. 2003 May;22(5):293-301.

Hess KA, Waltz SE, Chan EL, Degen SJ. Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function. Biol Reprod. 2003 Apr;68(4):1267-75. 

Sun WY, Coleman MJ, Witte DP, Degen SJ. Rescue of prothrombin-deficiency by transgene expression in mice. Thromb Haemost. 2002 Dec;88(6):984-91.

Leonis MA, Toney-Earley K, Degen SJ, Waltz SE. Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure. Hepatology. 2002 Nov;36(5):1053-60.