Steve C. Danzer, PhD

Associate Professor, UC Department of Anesthesia

Division of Neurobiology

Phone 513-636-4526

Email steve.danzer@cchmc.org

Epilepsy; autism; neurodevelopmental disease

Visit the Danzer Lab.

PhD: University of Arizona, Tucson, Arizona.

Postdoctoral Research: Duke University, Durham, NC.

Pun RYK, Rolle IJ, LaSarge CL, Hosford BE, Rosen JM, Uhl JD, Schmeltzer SN, Faulkner C, Bronson SL, Murphy BL, Richards DA, Holland KD, SC Danzer. Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy. Neuron. 2012;75(6):1022-34.

Castro OW, Santos VR, Pun RYK, McKlveen JM, Batie M, Holland KD, Gardner M, Garcia-Cairasco N, Herman JP, SC Danzer. Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsyPLoS One. 2012;7(9):e46044.

Murphy BL, Hofacer RD, Faulkner CN, Loepke AW and SC Danzer. Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced post-injury neurogenesisEpilepsia. 2012;53 (5):908-921.

Danzer SC. Depression, stress, epilepsy and adult neurogenesis. Experimental Neurology. 2012;233(1):22-32. 

Santos VR, Wagner de Castro O, Pun RYK, Hester MS, Murphy BL, Loepke AW, Garcia-Cairasco N and SC Danzer. Contributions of mature granule cells to structural plasticity in temporal lobe epilepsyNeuroscience. 2011;197:348-57.

Murphy BL and SC Danzer. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersionJournal of Neuroscience. 2011;31(8):2959-64.

Murphy BL, Pun RY, Yin H, Faulkner CR, Loepke AW and SC Danzer. Heterogeneous integration of adult-generated granule cells into the epileptic brain. Journal of Neuroscience. 2011;31(1):105-17.

McAuliffe JJ, Bronson SL, Hester MS, Murphy BL, Dahlquist-Topalá R, Richards DA and SC Danzer. Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy. Hippocampus. 2011 Jan;21(1):93-107.

Danzer SC. Postnatal and adult neurogenesis in the development of human diseaseNeuroscientist. ct;14(5):446-58. Review. 2008.

Walter C, Murphy BL, Pun RYK, Spieles-Engemann AL and SC Danzer. Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. Journal of Neuroscience. 2007 Jul;27(28):7541-52.

Contributions of aberrant granule cell integration to the development of epilepsy. Principal Investigator. National Institute of Health. 2009-14. 1R01-NS-062806.    

Selective disruption of hippocampal dentate granule cells in autism: impact of PTEN deletion. Principal Investigator. National Institute of Health. 2009-14. #1R01-NS-065020-01.