Takiko Daikoku, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2091

Fax 513-803-1160

Email takiko.daikoku@cchmc.org

Endometrial cancer and ovarian cancer initiation; molecular and genetic clues to embryo-uterine interactions during implantation

Visit the Daikoku Lab.

PhD: The University of Tokushima/Japan, 2000.

MS: The University of Tokushima/Japan, 1997.

BS: The University of Tokushima/Japan, 1995 .

Daikoku T, Jackson L, Besnard V, Whitsett J, Ellenson LH, Dey SK. Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes. Gynecol Oncol. 2011 May 12.

Hirota Y, Acar N, Tranguch S, Burnum KE, Xie H, Kodama A, Osuga Y, Ustunel I, Friedman DB, Caprioli RM, Daikoku T, Dey SK. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci USA. 2010 Aug 31;107(35):15577-82.

Hirota Y, Daikoku T, Tranguch S, Xie H, Bradshaw HB, Dey SK. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest. 2010 Mar 1;120(3):803-15.

Sun X, Jackson L, Dey SK, Daikoku T. In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus. Endocrinology. 2009 Nov;150(11):5065-73.

Zhuge Y, Lagman JA, Ansenberger K, Mahon CH, Daikoku T, Dey SK, Bahr JM, Hales DB. CYP1B1 expression in ovarian cancer in the laying hen Gallus domesticus. Gynecol Oncol. 2009;112:171-178.

Brown AJ, Alicknavitch M, D’Souza SS, Daikoku T, Kim-Safran CB, Marchetti D, Carson DD, Farach-Carson MC. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008;43:689-699. 

Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 2008;68:9331-9337.

Daikoku T, Dey SK. Two faces of PTEN. Nat Med. 2008:11:1192-1193.

Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK. Deficiency of immunophilin FKBP52 promotes endometriosis. Am J Pathology. 2008;173:1747-1757.

Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 2008;68(14): 5619-5627.