Maryam Fouladi, MD, MSc, FRCPC

Medical Director, Brain Tumor Center

Marjory J. Johnson Chair, Brain Tumor Translational Research

Professor, UC Department of Pediatrics

Phone 513-636-4266

Fax 513-636-3549

Email maryam.fouladi@cchmc.org

Dr. Maryam Fouladi graduated from the University of Toronto School of Medicine and completed her pediatric residency and hematology/oncology fellowship training at the Hospital for Sick Children in Toronto, Canada. Dr. Fouladi then completed her neuro-oncology fellowship training at St. Jude Children’s Research Hospital and later completed further training in the Molecular Pharmacology Department at St. Jude before becoming a neuro-oncology faculty member in 2000. She served as the Chair of the Phase I Committee at St. Jude.

Dr. Fouladi moved to Cincinnati Children’s Hospital Medical Center in 2008 to become the Medical Director of the Neuro-Oncology Program. Dr. Fouladi is currently a full professor and the Marjory J. Johnson Endowed Chair in Brain Tumor Translational Research. Dr. Fouladi was elected Chair of the Pediatric Brain Tumor Consortium (PBTC) from 2012-2016. She has chaired multiple national and institutional Phase I, II, and III clinical trials of new agents for central nervous system (CNS) malignancies through the Children’s Oncology Group (COG), the Pediatric Brain Tumor Consortium (PBTC), and local studies. Dr. Fouladi co-chairs the CNS New Agents Subcommittee at COG and she is a member of the CNS Steering Committee and a former member of the Developmental Therapeutics Steering Committee of the COG. Dr. Fouladi has extensive experience in the development and execution of trials, translational research and helping guide the agenda for pediatric neuro-oncology clinical trials nationally.

BS: Human Biology, University of Toronto, Toronto, Canada, 1987.

MD: University of Toronto, Toronto, Canada, 1991.

MSc: Institute of Medical Science, University of Toronto, Toronto, Canada, 2002.

View PubMed Publications

Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones D, Capper D, Still M, Boughhalter I, Northcott P, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen S, Balasubramanian G, Worst B, Pajtler K, Brabetz S, Johann P, Sahm F, Reimand J, Mackay A, Carvalho D, Remke M, Phillips J, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lotsch D, Berger W, Slave I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley B, Schiederjan M, Santi M, Buccoliero A, Dahiya S, Kramm C, Von Hoff K, Rutkowski S, Herold-Mende C, Fruhwald M, Milde T, Hasselblatt M, Wesseling P, Rossler J, Schueller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Scheppenheim R, Zitterbart K, Collins V.P, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, Van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester L, Koster J, Versteeg R, Volckmann R, Van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore A, Taylor M, Jones C, Jabado N, Karajannis M, Eils R, Schlesner M, Lichter P, Vol Deimling A, Pfister S, Ellison D, Korshunov A, Kool M. New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 2016 Feb 25;164(5):1060-72.

Hoffman LM, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, Ramani A, Brudno M, Kumar SS, Drissi R, Dexheimer P, Salloum R, Chow L, Hummel T, Stevenson C, Lu QR, Jones B, Witte D, Aronow B, Hawkins CE, Fouladi M. Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol Commun. 2016 Jan 4;4(1):1.

Hummel TR, Salloum R, Drissi R, Kumar S, Sobo M, Goldman S, Pai A, Leach J, Lane A, Pruitt D, Sutton M, Chow LM, Grimme L, Doughman R, Backus L, Miles L, Stevenson C, Fouladi M, DeWire M. A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas. J Neurooncol. 2016 Mar;127(1):53-61.

Poussaint TY, Vajapeyam S, Ricci KI, Panigrahy A, Kocak M, Kun LE, Boyett JM, Pollack IF, Fouladi M. Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 2015 Oct 20.

Studebaker A, Bondra K, Seum S, Shen C, Phelps DA, Chronowski C, Leasure J, Smith PD, Kurmasheva RT, Mo X, Fouladi M, Houghton PJ. Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma. Pediatr Blood Cancer. 2015 Oct;62(10):1768-74.

Kieran MW, Chi S, Goldman S, Onar-Thomas A, Poussaint TY, Vajapeyam S, Fahey F, Wu S, Turner DC, Stewart CF, Moses M, Packer RJ, Jakacki R, Banerjee A, Boyett JM, Fouladi M, Kun L. A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors. Childs Nerv Syst. 2015 Sep;31(9):1433-45.

Robinson GW, Orr BA, Wu G, Gururangan S, Lin T, Qaddoumi I, Packer RJ, Goldman S, Prados MD, Desjardins A, Chintagumpala M, Takebe N, Kaste SC, Rusch M, Allen SJ, Onar-Thomas A, Stewart CF, Fouladi M, Boyett JM, Gilbertson RJ, Curran T, Ellison DW, Gajjar A. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. J Clin Oncol. 2015 Aug 20;33(24):2646-54.

Davis J, Kreppel AJ, Brady RC, Jones B, Stevenson CB, Fouladi M, Hummel TR. Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. J Pediatr Hematol Oncol. 2015 Aug;37(6):482-5.

Hoffman LM, Fouladi M, Olson J, Daryani VM, Stewart CF, Wetmore C, Kocak M, Onar-Thomas A, Wagner L, Gururangan S, Packer RJ, Blaney SM, Gajjar A, Kun LE, Boyett JM, Gilbertson RJ. Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. Childs Nerv Syst. 2015 Aug;31(8):1283-9.

Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med. 2015 Jul;21(7):827.