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High Res

Tsuyoshi Fukuda, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-803-0428

Fax: 513-636-0168

Email: tsuyoshi.fukuda@cchmc.org

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Specialties

Clinical pharmacology (pharmacogenetics, pharmacokinetics and pharmacodynamics)

Biography

Dr. Fukuda received his Pharmacy degree and PhD in Pharmaceutical Science from Osaka University, Japan. He received postdoctoral training in the department of Clinical Pharmacology and Pharmacogenomics (Prof. J. Azuma, MD) and served as an Assistant Professor at Osaka University, Graduate School of Pharmaceutical Sciences. Dr. Fukuda spent over 10 years in the field of Clinical Pharmacology while engaged in Pharmacogenetic research. Dr. Fukuda’s efforts have resulted in over 40 peer-reviewed publications with project members that include Master level and Ph.D. students, clinical fellows, and private sector R & D staff. He was awarded The Japanese Society of Clinical Pharmacology and Therapeutics Research Prize as its youngest recipient in 2003.

Dr. Fukuda joined the Division of Clinical Pharmacology (Prof. Alexander A Vinks, PharmD, PhD) at Cincinnati Children's Hospital Medical Center in 2007. His current research interests include the clinical application of pharmacogenetics and pharmacokinetic-pharmacodynamic (PK/PD) modeling and simulation, focusing on improving our understanding of inter-patient differences in drug response and developing individualized dosing strategies in pediatric patients.

Education and Training

BS: Osaka University, School of Pharmacy, Osaka, Japan, 1995.

Pharmacist: Japan, 1995.

MS: Osaka University, Osaka, Japan,1997.

PhD: Osaka University, Osaka, Japan, 2000.

Certification: Clinical Pharmacology (Pharmacist), 2003 (Japanese Society of Clinical Pharmacology), 2008 renewed.

Publications

View PubMed Publications

Sherwin CM, Fukuda T, Brunner HI, Goebel J, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan 1;50(1):1-24. doi: 10.2165/11536640-000000000-00000.PMID: 21142265

Sagcal-Gironella AC, Fukuda T, Wiers K, Cox S, Nelson S, Dina B, Sherwin CM, Klein-Gitelman MS, Vinks AA, Brunner HI. Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid and Their Relation to Response to Therapy of Childhood-Onset Systemic Lupus Erythematosus. Semin Arthritis Rheum. 2010 Jul 22.

Fukuda T, Goebel J, Thøgersen H, Maseck D, Cox S, Logan B, Sherbotie J, Seikaly M, Vinks AA. Inosine Monophosphate Dehydrogenase (IMPDH) Activity as a Pharmacodynamic Biomarker of Mycophenolic Acid Effects in Pediatric Kidney Transplant Recipients. J Clin Pharmacol. 2010 Apr 23.

Sherwin CM, Fukuda T, Brunner HI, Goebel J, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet 2010.

Nakamura N, Fukuda T, Nonen S, Hashimoto K, Azuma J, Gemma N. Simple and accurate determination of CYP2D6 gene copy number by a loop-mediated isothermal amplification method and an electrochemical DNA chip. Clinical Chem Act 2010 Jan 20.

Prausa SE, Fukuda T, Maseck D, Curtsinger KL, Liu C, Zhang K, Nick TG, Sherbotie JR, Ellis EN, Goebel J, Vinks AA. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clin Pharmacol Ther. 2009 May;85(5):495-500.

Kato M, Fukuda T, Wakeno M, Okugawa G, Takekita Y, Watanabe S, Yamashita M, Hosoi Y, Azuma J, Kinoshita T, Serretti A. Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):115-23.

Yamamoto A, Nonen S, Fukuda T, Yamazaki H, Azuma J. Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. Drug Metab Pharmacokinet. 2009;24(1):114-7.

Kato M, Fukuda T, Wakeno M, Okugawa G, Takekita Y, Serretti A, Azuma J, Kinoshita T. 5-HT1A gene polymorphisms contributed to antidepressant response in major depression. Nihon Shinkei Seishin Yakurigaku Zasshi. 2009 Feb;29(1):23-31.

Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T. ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 15;32(2):398-404.