Christina Gross, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3493

Email christina.gross@cchmc.org

Research

Molecular neuroscience, fragile X syndrome

Visit the Gross Lab.

Diploma in Biochemistry: Ruhr University Bochum, Germany, 2000.

PhD: Free University of Berlin, Germany, 2004.

Sasaki Y, Gross C, Xing L, Goshima Y, Bassell GJ. Identification of axon-enriched microRNAs localized in growth cones of cortical neurons. Dev Neurobiol. 2014 Mar;74(3):397-406.

Gross C, Bassell GJ. Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders. Front Mol Neurosci. 2014 Feb 13;7:12.

Gross C, Bassell GJ. Excess Protein Synthesis in FXS Patient Lymphoblastoid Cells Can Be Rescued with a p110beta-Selective Inhibitor. Mol Med. 2012 May 9;18:336-45.

Gross C, Berry-Kravis EM, Bassell GJ. Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond. Neuropsychopharmacology. 2012 Jan;37(1):178-95.

Swanger SA, Bassell GJ, Gross C. High-Resolution Fluorescence In Situ Hybridization to Detect mRNAs in Neuronal Compartments In Vitro and In Vivo. Methods Mol Biol. 2011;714:103-123.

Jakkamsetti V, Tsai N-P, Gross C, Molinaro G, Collins KA, Nicoletti F, Wang KH, Osten P, Bassell GJ, Gibson JR, Huber KM. Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression. Neuron. 2013 Oct 2;80(1):72-9.

Pak C, Garshasbi M, Kahrizi K, Gross C, Apponi  LH, Noto JJ, Kelly SM, Leung SW, Tzschach A, Behjati F, Abedini SS, Mohseni M, Jensen LR, Hu H, Huang B, Stahley  SN, Liu G, Williams KR, Burdick S, Feng Y, Sanyal S, Bassell GJ, Ropers HH, Najmabadi H, Corbett AH, Moberg K, Kuss AW. Mutation of a Conserved Polyadenosine RNA binding Protein, ZC3H14/dNab2, Impairs Neural Function in Drosophila and Humans. Proc Natl Acad Sci USA. 2011 Jul 26;108(30):12390-5.

Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, Bassell GJ. Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation and mGluR signaling. Mol Cell. 2011 Jun 10;42(5):673-88.

Gross C, Yao X, Pong DL, Jeromin A, Bassell GJ. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J Neurosci. 2011 Apr 13;31(15):5693-8.

Gross C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ. Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci. 2010 Aug 11;30(32):10624-38.