Christina Gross, PhD

Assistant Professor, UC Department of Pediatrics

Molecular neuroscience, fragile X syndrome

Visit the Gross Lab.

Diploma in Biochemistry: Ruhr University Bochum, Germany, 2000.

PhD: Free University of Berlin, Germany, 2004.

View PubMed Publications

Gross C*, Raj N, Gemma M, Amanda AG, Whyte AJ, Gibson JR, Huber KM, Gourley SL, Bassell GJ*. Selective role of the catalytic PI3K subunit p110β in impaired higher-order cognition in Fragile X syndrome. Cell reports. 2015;11:681-688. *co-corresponding authors.

Gross C*, Chia-Wei C, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ*. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in Fragile X syndrome. Cell reports. 2015;11:727-736. *co-corresponding authors.

Gross C, Hoffmann A, Bassell GJ, Berry-Kravis EM. Therapeutic Strategies in fragile X syndrome: from bench to bedside and back. Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics. 2015;1-25. 

Sasaki Y, Gross C, Xing L, Goshima Y, Bassell GJ. Identification of axon-enriched microRNAs localized in growth cones of cortical neurons. Dev Neurobiol. 2014 Mar;74(3):397-406.

Gross C, Bassell GJ. Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders. Front Mol Neurosci. 2014 Feb 13;7:12.

Jakkamsetti V, Tsai N-P, Gross C, Molinaro G, Collins KA, Nicoletti F, Wang KH, Osten P, Bassell GJ, Gibson JR, Huber KM. Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression. Neuron. 2013 Oct 2;80(1):72-9.

Gross C, Bassell GJ. Excess Protein Synthesis in FXS Patient Lymphoblastoid Cells Can Be Rescued with a p110beta-Selective Inhibitor. Mol Med. 2012 May 9;18:336-45.

Gross C, Yao X, Pong DL, Jeromin A, Bassell GJ. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J Neurosci. 2011 Apr 13;31(15):5693-8.

Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, Bassell GJ. Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation and mGluR signaling. Mol Cell. 2011 Jun 10;42(5):673-88.

Gross C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ. Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci. 2010 Aug 11;30(32):10624-38.