Elke Grassman, PhD

Director, Translational Trials Development and Support Laboratory

Field Service Assistant Professor, UC Department of Pediatrics

Phone 513-636-0958

Fax 513-636-1446

Email elke.grassman@cchmc.org

Clinical Interests

Diagnostic assay for the identification of complementation groups on specimens from patients diagnosed with Fanconi Anemia

Research Interests

Phase I gene transfer / cell therapy trials; investigational new drug (IND) submissions to the FDA; evaluate new vectors with respect to safety and efficacy; develop tailored assays for trial monitoring; stat Endotoxin testing service to support cell therapy trials

MS: University of Würzburg, Würzburg, Germany, 1995.

PhD: University of Göttingen, Göttingen, Germany, 1999.

Singh TR, Bakker ST, Agarwal S, Jansen M, Grassman E, Godthelp BC, Ali AM, Du CH, Rooimans MA, Fan Q, Wahengbam K, Steltenpool J, Andreassen PR, Williams DA, Joenje H, de Winter JP, Meetei AR. Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group MBlood. 2009 Jul 2;114(1):174-80. Epub 2009 May 7.

Balcik B, Grassman E, Reeves L. Database setup for preclinical studies of gene-modified hematopoiesis. Methods Mol Biol. 2009;506:467-76.

Schuesler T, Reeves L, Kalle C, Grassman E. Copy number determination of genetically-modified hematopoietic stem cells. Methods Mol Biol. 2009;506:281-98.

Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, Von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, Reeves L, Williams DA. Importance of murine study design for testing toxicity of retroviral vectors in support of Phase I trials. Mol Ther. 2007 Apr 15(4):782-91.

Li Z, Kustikova OS, Kamino K, Neumann T, Rhein M, Grassman E, Fehse B, Baum C. Mutagenesis by Replication-Deficient Retroviral Vectors Encoding the Large T Oncogene. Annals of the New York Academy of Sciences. 2007 1106:95-113.

Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ. Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Mol Ther. 2008 16(3):590-8.

Zychlinski D, Schambach A, Modlich U, Maetzig T, Meyer J, Grassman E, Mishra A, Baum C. Physiological promoters reduce the genotoxic risk of integrating gene vectors. Mol Ther. 2008 16(4):718-25.