Fukun Guo, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-1118

Email fukun.guo@cchmc.org

Rho GTPases and T and B lymphocyte development and function

BS: Jilin University, Changchun, Jilin, China,1994.

MS: Academy of Military Medical Sciences, Beijing, China, 1997.

PhD: Southern Medical University, Guangzhou, Guangdong, China, 2000.

Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2000-2002; Children’s Hospital Medical Center, Cincinnati, OH, 2002-2004.

Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000. Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Research Instructor: Children’s Hospital Medical Center, Cincinnati, OH. 2005-2009

Sachin Kumar, Juying Xu, Charles Perkins, Fukun Guo, Scott Snapper, Fred D Finkelman, Yi Zheng, Marie-Dominique Filippi. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood. 2012;120(17):3563-3574.

Juan Li, Nuyun Liu, Kangrong Lu, Lei Zhang, Jingjing Gu, Fukun Guo, Shengli An, Lin Zhang, Lu Zhang. Cocaine-induced dendritic remodeling occurs in both D1 and D2 dopamine receptor-expressing neurons in the nucleus accumbens. Neuroscience Letters. 2012;517(2):118-122.

Shuangmin Zhang, Xuan Zhou, Richard A Lang, Fukun Guo*. RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS One. 2012.7(3):e33773 (*corresponding author).

Jessica G Woo, M Lourdes Guerrero, Fukun Guo, J Martin, Barbara S Davidson, Hilda Ortega, Guillermo M Ruiz-Palacios, Ardythe L Morrow. Human Milk Adiponectin Impacts Infant Weight Trajectory During The Second Year Of Life. Journal of Pediatric Gastroenterology & Nutrition. 2012;54(4):532-539.

Guo F, Cancelas JA, Hildeman D, Williams DA, Zheng Y. Rac GTPase isoforms, Rac1 and Rac2, play a redundant and crucial role in T-cell development. Blood. 2008; 112 (5):1767.

Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PLoS One. 2011; 6(3):e18002.

Shang X, Cancelas JA, Li L, Guo F, Liu W, Johnson JF, Ficker A, Daria D, Geiger H, Ratner N, Zheng Y. R-Ras and Rac GTPase crosstalk regulates hematopoietic progenitor cell migration, homing and mobilization. Journal of Biological Chemistry. 2011; 286(27):24068.

Sipes NS, Feng Y, Guo F, Lee HO, Chou FS, Cheng J, Mulloy J, Zheng Y. Cdc42 regulates extracellular matrix remodeling in three dimensions. Journal of Biological Chemistry. 2011; 286(42):36469-77. 

Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18505-10.

Bosco EE, Ni W, Wang L, Guo F, Johnson JF, Zheng Y. Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. Blood. 2010 Apr 22;115(16):3320-8.