Geraldine Guasch, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2607

Email geraldine.guasch@cchmc.org

Research Interests

Role of stem cells in tumor development; skin cancers; genetics; biochemical studies

Visit the Guasch Lab.

Postdoctoral research fellow: The Rockefeller University, New York, NY, 2002-2008.

PhD: University of Aix-Marseille, France, Immunology/Oncology, 2002.

BS: University Montpellier II, France, Biochemistry, 1997.

View PubMed Publications

McCauley H.A, Liu C-Y, Attia A, Wikenheiser-Brokamp KA, Zhang Y, Whitsett JA, Guasch G. TGFβ signaling inhibits goblet cell differentiation via SPDEF in the conjunctival epithelium. Development. 2014 Dec:141(23):4628-39.

Gupta A, Bischoff A, Peña A, Runck LA, Guasch G. The great divide: septation and malformation of the cloaca, and its implications for surgeons. Pediatr Surg Int. 2014 Nov;30(11):1089-95.

Runck LA, Method A, Bischoff A, Levitt M, Peña A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G. Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93.

McCauley HA, Guasch G. Serial orthotopic transplantation of epithelial tumors in single-cell suspension. Methods Mol Biol. 2013;1035:231-45.

McNairn AJ, Brusadelli M, Guasch G. Signaling moderation: TGF-β in exocrine gland development, maintenance, and regulationEur J Dermatol. 2013 Apr 10.

Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E. NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared nicheNature. Mar 7 2013.

McNairn AJ, Doucet Y, Demaude J, Brusadelli M, Gordon CB, Uribe-Rivera A, Lambert PF, Bouez C, Breton L, Guasch G. TGFβ signaling regulates lipogenesis in human sebaceous glands cellsBMC Dermatol. 2013.

McNairn A, Guasch G. Epithelial Transition Zones: merging microenvironments, niches, and cellular transformation. Eur J Dermatol. 2011;21(Suppl.2):21-28.

Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in miceCell Cycle. 2010 Aug 1;9(15):3039-45. 

Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. Loss of TGF beta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epitheliaCancer Cell. 2007 Oct;12(4):313-27.