In our laboratory we are using the mouse as a model system to investigate the role of stem cells in tumor development. Our long-term goal is to understand whether skin cancers arise from stem cells and whether tumors maintain stem cells, using a combination of genetics and biochemical studies.

Visit the Guasch Lab.

Postdoctoral research fellow: The Rockefeller University, New York, NY, 2002-2008.

PhD: University of Aix-Marseille, France, Immunology/Oncology, 2002.

BS: University Montpellier II, France, Biochemistry, 1997.

McNairn A, Guasch G. Epithelial Transition Zones: merging microenvironments, niches, and cellular transformation. Eur J Dermatol. 2011;21(Suppl.2):21-28.

Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell Cycle. 2010 Aug 1;9(15):3039-45. 

Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell. 2007 Oct;12(4):313-27.

Li J, Greco V, Guasch G, Fuchs E, Mombaerts P. Mice cloned from skin cells. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2738-43.

Guasch G. [Epithelial stem cells in the skin]. Med Sci (Paris). 2006 Aug-Sep;22(8-9):710-2. French.

Guasch G, Fuchs E. Mice in the world of stem cell biology. Nat Genet. 2005 Nov;37(11):1201-6. Review.

Lowry WE, Blanpain C, Nowak JA, Guasch G, Lewis L, Fuchs E. Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev. 2005 Jul 1;19(13):1596-611.

Guasch G, Blanpain C. [Defining the epithelial stem cell niche in skin]. Med Sci (Paris). 2004 Mar;20(3):265-7. French.

Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell. 2004 Mar 19;116(6):769-78. Review.

Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E. Defining the epithelial stem cell niche in skin. Science. 2004 Jan 16;303(5656):359-63.

Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pébusque MJ. FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. Blood. 2004 Jan 1;103(1):309-12.