Geraldine Guasch, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2607

Email geraldine.guasch@cchmc.org

Research Interests

Role of stem cells in tumor development; skin cancers; genetics; biochemical studies

Visit the Guasch Lab.

Postdoctoral research fellow: The Rockefeller University, New York, NY, 2002-2008.

PhD: University of Aix-Marseille, France, Immunology/Oncology, 2002.

BS: University Montpellier II, France, Biochemistry, 1997.

McCauley H.A, Liu C-Y, Attia A, Wikenheiser-Brokamp KA, Zhang Y, Whitsett JA, Guasch G. TGFβ signaling inhibits goblet cell differentiation via SPDEF in the conjunctival epithelium. Development. 2014. In press.

Gupta A, Bischoff A, Peña A, Runck LA, Guasch G. The great divide: septation and malformation of the cloaca, and its implications for surgeons. Pediatr Surg Int. 2014 Sep 14. Epub ahead of print.

Runck LA, Method A, Bischoff A, Levitt M, Peña A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G. Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93.

McCauley HA, Guasch G. Serial orthotopic transplantation of epithelial tumors in single-cell suspension. Methods Mol Biol. 2013;1035:231-45.

McNairn AJ, Brusadelli M, Guasch G. Signaling moderation: TGF-β in exocrine gland development, maintenance, and regulationEur J Dermatol. 2013 Apr 10.

Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E. NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared nicheNature. Mar 7 2013.

McNairn AJ, Doucet Y, Demaude J, Brusadelli M, Gordon CB, Uribe-Rivera A, Lambert PF, Bouez C, Breton L, Guasch G. TGFβ signaling regulates lipogenesis in human sebaceous glands cellsBMC Dermatol. 2013.

McNairn A, Guasch G. Epithelial Transition Zones: merging microenvironments, niches, and cellular transformation. Eur J Dermatol. 2011;21(Suppl.2):21-28.

Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in miceCell Cycle. 2010 Aug 1;9(15):3039-45. 

Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. Loss of TGF beta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epitheliaCancer Cell. 2007 Oct;12(4):313-27.