Minzhe Guo.

Minzhe Guo, PhD


  • Assistant Professor, UC Department of Pediatrics

About

Interests

Developing novel computational methods and software tools to support single cell multi-omics data analysis and integration for scientific discovery or to facilitate data management, access, and visualization; Applying expertise in computations, bioinformatics and single-cell multiomic data analysis to study important questions in lung development and diseases, including perinatal lung maturation and lung adaptation at birth, idiopathic pulmonary fibrosis, mucinous adenocarcinoma of the lung, lymphangioleiomyomatosis, bronchopulmonary dysplasia, cystic fibrosis, and alveolar capillary dysplasia

Research Areas

Pulmonary Biology

Publications

Selected

Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.

Selected

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Muus, C; Luecken, MD; Eraslan, G; Sikkema, L; Waghray, A; Heimberg, G; Kobayashi, Y; Vaishnav, ED; Subramanian, A; Smillie, C; Smith, NP; Sountoulidis, A; Strunz, M; Sullivan, TB. Nature Medicine. 2021; 27:546-559.

Selected

In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; Kalin, TV; Whitsett, JA; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Selected

Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. Du, Y; Ouyang, W; Kitzmiller, JA; Guo, M; Zhao, S; Whitsett, JA; Xu, Y. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:146-149.

Selected

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; Kwiatkowski, DJ; Whitsett, JA; McCormack, FX; Xu, Y. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Selected

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes. Wang, A; Chiou, J; Poirion, OB; Buchanan, J; Valdez, MJ; Verheyden, JM; Hou, X; Kudtarkar, P; Narendra, S; Newsome, JM; Xu, Y; Gaulton, KJ; Preissl, S; Sun, X. eLife. 2020; 9.

Selected

CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions. Stuart, WD; Guo, M; Fink-Baldauf, IM; Coleman, AM; Clancy, JP; Mall, MA; Lim, FY; Brewington, JJ; Maeda, Y. NAR Genomics and Bioinformatics. 2020; 2:lqaa036.

Selected

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Basil, MC; Katzen, J; Engler, AE; Guo, M; Herriges, MJ; Kathiriya, JJ; Windmueller, R; Ysasi, AB; Zacharias, WJ; Chapman, HA; Snoeck, H; Vunjak-Novakovic, G; Whitsett, JA; Morrisey, EE. Cell Stem Cell. 2020; 26:482-502.

Selected

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; Whitsett, JA; Xu, Y. Nature Communications. 2019; 10:37.

Selected

Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.