Biophysical and crystallographic studies of cellular adhesion and receptor signaling
Education and Training
BA: Biomedical Chemistry, Oral Roberts University, Tulsa, OK.
PhD: Molecular Biophysics , Washington University, St. Louis, MO.
Fellowship: California Institute of Technology, Pasadena, CA.
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Herr AB, Conrady DG. Thermodynamic analysis of metal ion-induced protein assembly. Methods Enzymol. 2011;488:101-21.
Conrady DG, Flagler MJ, Friedmann DR, Vander Wielen BD, Kovall RA, Weiss AA, Herr AB. Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2. PLoS One. 2010 Dec 28;5(12):e15153.
Gomes, MM, H Suzuki, MT Brooks, M Tomana, Z Moldovanu, J Mestecky, BA Julian, J Novak, Herr AB. Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study. Biochemistry. 2010;49:5671-5682.
Horii K, Brooks MT, Herr AB. Convulxin forms a dimer in solution and can bind eight copies of glycoprotein VI: implications for platelet activation. Biochemistry. 2009 Apr 7;48(13):2907-14.
Conrady DG, Brescia CC, Horii K, Weiss AA, Hassett DJ, Herr AB. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19456-61.
Gomes MM, Wall SB, Takahashi K, Novak J, Renfrow MB, Herr AB. Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding. Biochemistry. 2008 Oct 28;47(43):11285-99.
West AP Jr, Herr AB, Bjorkman PJ. The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog. Immunity. 2004 May;20(5):601-10.
Herr AB, White CL, Milburn C, Wu C, Bjorkman PJ. Bivalent binding of IgA1 to FcalphaRI suggests a mechanism for cytokine activation of IgA phagocytosis. J Mol Biol. 2003 Mar 28;327(3):645-57.
Herr AB, Ballister ER, Bjorkman PJ. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Nature. 2003 Jun 5;423(6940):614-20.
Ornitz DM, Herr AB, Nilsson M, Westman J, Svahn CM, Waksman G. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science. 1995 Apr 21;268(5209):432-6.