Andrew B. Herr, PhD

Associate Professor, UC Department of Pediatrics

Phone 513-803-7490

Email andrew.herr@cchmc.org

Research

Structural biology and biophysics of antibodies; immune receptors; bacterial surface proteins

Andrew Herr, PhD, is an associate professor in the Division of Immunobiology and Center for Systems Immunology, with an affiliate appointment in the Division of Infectious Diseases. Dr. Herr completed his thesis work in molecular biophysics from Washington University in St. Louis, and completed his postdoctoral work in structural immunology at the California Institute of Technology as a Damon Runyon Research Fellow. He was recruited to the University of Cincinnati College of Medicine as an Ohio Eminent Scholar in Structural Biology before moving to Cincinnati Children’s Hospital.

Dr. Herr solved the first structure of a human IgA1 antibody bound to its cognate Fc receptor while at Caltech, and his lab has continued to study antibodies and immune receptors implicated in autoimmune diseases. In addition, the lab is studying a family of related collagen-specific immune receptors such as glycoprotein VI, which activates platelets upon exposure to fibrous collagen. The Herr lab also studies mechanisms of bacterial pathogenesis. Specifically, they discovered the zinc-dependent mechanism of intercellular adhesion in bacterial biofilms formed by Staphylococcus epidermidis and S. aureus. Biofilms are specialized bacterial colonies that are highly resistant to antibiotics and immune responses, so developing novel therapies to prevent biofilm formation is of high importance.

Before joining the faculty at Cincinnati Children’s, Dr. Herr was an Ohio Eminent Scholar in Structural Biology at the University of Cincinnati College of Medicine and served as an associate director of the Cincinnati Medical Scientist (MD/PhD) Training Program. Dr. Herr received the 2014 Emerging Entrepreneurial Achievement Faculty Award from UC for his work to commercialize a novel anti-infective therapy based on his lab’s research.

BA: Oral Roberts University, Tulsa, OK, 1993.

PhD: Washington University Medical School, St. Louis, MO, 1999.

Postdoc: California Institute of Technology, Pasadena, CA, 2003.

Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerizationImmunity. 2013 Dec 12;39(6):1019-31.

Conrady DG, Wilson JJ, Herr AB. Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E202-11.

Herr AB, Conrady DG. Thermodynamic analysis of metal ion-induced assembly. Methods Enzymol. 2011;488:101-21.

Herr AB, Farndale RW. Structural insights into the interactions between platelet receptors and fibrillar collagen. J Biol Chem. 2009 Jul 24;284(30):19781-5.

Horii K, Brooks MT, Herr AB. Convulxin forms a dimer in solution and can bind eight copies of glycoprotein VI: Implications for platelet activation. Biochemistry. 2009 Apr 7;48(13):2907-14.

Conrady DG, Brescia CC, Horii K, Weiss AA, Hassett DJ, Herr AB. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19456-61.

Gomes, MM, SB Wall, K Takahashi, J Novak, MB Renfrow, and AB Herr. Analysis of IgA1 N-glycosylation and its contribution to FcaRI binding. Biochemistry. 2008 Oct 28;47(43):11285-99.

Horii K, Kahn ML, Herr AB. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 2006 Aug 1;108(3):936-42.

Herr, AB, ER Ballister, and PJ Bjorkman. Insights into IgA-mediated immune responses from the crystal structures of human FcaRI and its complex with IgA1-Fc. Nature. 2003 Jun 5;423(6940):614-20.

Ornitz DM, Herr AB, Nilsson M, Westman J, Svahn CM, Waksman G. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science. 1995 Apr 21;268(5209):432-6.

Studies of metal-dependent intercellular adhesion in Staphylococcal biofilms. Principal Investigator. National Institutes of Health. Sep 2011 – Jun 2015. NIH R01 GM094363.

Analytical tools for the analysis of clustered O-glycans in clinical samples. Principal Investigator of Sub-contract. National Institutes of Health. Sep 2011 – Jul 2015. NIH R01 GM098539.