David A. Hildeman, PhD

Director, Immunology Graduate Program

Associate Professor, UC Department of Pediatrics

Phone: 513-636-3923

Fax: 513-636-5355


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Clinical Interests

T cells; autoimmunity; sex differences in immune responses; apoptosis

Research Interests

Our lab is primarily interested in molecular factors that control the decision between tolerance and immunity within T lymphocytes. We use staphylococcal enterotoxins, recombinant vaccinia viruses, lymphocytic choriomeningitis virus and MHC tetrameric reagents as tools to study antigen -specific T cell responses. Our interest in tolerance centers on regulation of mechanisms that control the survival and death of activated T cells in vivo, namely Bcl-2 and its antagonist Bim. We are also interested in the manipulation and regulation of antigen-specific T cell responses via novel vaccine strategies to either induce tolerance or enhance immunity. Finally, we are interested in mechanisms underlying sex-based differences in T cell responses and how these differences relate to autoimmune disease.

Education and Training

PhD:  University of Wisconsin-Madison, Madison, Wisconsin, 1997.


View PubMed Publications


Regulation of Apoptosis in Activated Primary T Cells. Principal Investigator. National Institute of Allergy and Infectious Diseases. Dec 2008 – Nov 2013. #R01 AI057753. 

Homeostasis and function of regulatory T cells in aging. Co-Principal Investigator. National Institute on Aging. Sep 2009 - Aug 2011.  #RO1 AG3054748.