Rashmi S. Hegde, PhD

Professor, UC Department of Pediatrics

Phone: 513-636-5947

Fax: 513-636-6772


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Clinical Interests

Research in the Hegde Laboratory is aimed at understanding the structural basis for specificity in macromolecular interactions. Currently the two main areas of interest in the laboratory are: proteins involved in early vertebrate development; proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses

Research Interests

Molecular mechanisms underlying early stages in embryonic organ development; molecular basis of developmental defects and cancer; protein-DNA interactions; X-ray crystallography

Visit the Hegde Lab.


Rashmi Hegde received her PhD in Medicinal Chemistry from the University of Pittsburgh in 1989. She received post-doctoral training in the Department of Molecular Biophysics and Biochemistry at Yale University, where she was a fellow of the National Cancer Center. She was appointed Assistant Professor of Biochemistry at New York University School of Medicine and the Skirball Institute of Biomolecular Medicine in 1994. She is presently a full Professor in the Department of Pediatrics, University of Cincinnati College of Medicine and the Division of Developmental Biology at Children's Hospital Research Foundation.

Education and Training

PhD: University of Pittsburgh, Pittsburgh, PA, 1989.

Post-doctoral Fellowship: Yale University, 1989-1994.

Assistant Professor: New York University School of Medicine, Skirball Institute, 1994-2000.

Associate Professor: (2001 - 2007) Cincinnati Children's Hospital Medical Center.

Professor (2008 - present): Cincinnati Children's Hospital Medical Center.


View PubMed Publications


Mechanism of Action of Retinal Determination Proteins. NIH/NEI  RO1 EY014648  (2004 – 2013) Principal Investigator. 

The long-term objective of this project is to decipher the mechanisms of action of the Dachshund and Eyes Absent proteins in eye development.

Eyes Absent phosphatase inhibitors in eye diseases. NIH/NEI R21 EY019125 (07/01/09 – 06/30/11) Principal Investigator.                 

This small, exploratory grant supported high-throughput screening for small molecule inhibitors of the Eyes Absent phosphatase.

CRIM1-ß-catenin- Cadherin interactions in Eye Development and Disease. NIH/NEI R01 EY019377  (07/01/09 – 06/30/11) (MPI)

The major goal of this project is to investigate the role of cadherin-catenin interactions in both eye disease and development.