Rashmi S. Hegde, PhD

Professor, UC Department of Pediatrics

Phone 513-636-5947

Fax 513-636-6772

Email rashmi.hegde@cchmc.org

Clinical Interests

Research in the Hegde Laboratory is aimed at understanding the structural basis for specificity in macromolecular interactions. Currently the two main areas of interest in the laboratory are: proteins involved in early vertebrate development; proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses.

Research Interests

Molecular mechanisms underlying early stages in embryonic organ development; molecular basis of developmental defects and cancer; protein-DNA interactions; X-ray crystallography.

Visit the Hegde Lab.

Rashmi Hegde received her PhD in medicinal chemistry from the University of Pittsburgh in 1989. She received post-doctoral training in the Department of Molecular Biophysics and Biochemistry at Yale University, where she was a fellow of the National Cancer Center. She was appointed assistant professor of biochemistry at New York University School of Medicine and the Skirball Institute of Biomolecular Medicine in 1994. She is presently a full professor in the Department of Pediatrics, University of Cincinnati College of Medicine and the Division of Developmental Biology at Children's Hospital Research Foundation.

PhD: University of Pittsburgh, Pittsburgh, PA, 1989.

Post-doctoral Fellowship: Yale University, 1989-1994.

Assistant Professor: New York University School of Medicine, Skirball Institute, 1994-2000.

Associate Professor: Cincinnati Children's Hospital Medical Center, 2001-2007.

Professor: Cincinnati Children's Hospital Medical Center, 2008-present.

Tadjuidje E, Wang TS, Pandey RN, Sumanas S, Lang RA, Hegde RS.  The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by BenzbromaronePLoS One. 2012;7(4):e34806.

Korfhagen TR, Kitzmiller J, Chen G, Sridharan A, Haitchi HM, Hegde RS, Divanovic S, Karp CL, Whitsett J. SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16630-5.

Tadjuidje E, Hegde RS. The Eyes Absent proteins in development and diseaseCell Mol Life Sci. Sept. 13. 2012. Epub ahead of print.

Riazuddin S, Belyantseva IA, Giese A, Kwanghyuk L, Indzhykulian A, Nandamuri SP, Yousaf R, Lee S, Terrell D, Hegde RS, Morell RJ, Ali RA, Anwar S, Rachel RA, Andrade-Elizondo PB, Sirmaci A, Husnain T, Khan SN, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Swaroop A, Ahmad W, Tekin M, Riazuddin S, Cook T, Buschbeck E, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZA. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48Nat Genet. 2012 Sep 30;44(11):1265-71.

Ponferrada VG, Fan J, Vallance JE, Hu S, Mamedova A, Rankin SA, Zorn AM, Hegde RS*, Lang RA.* CRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesisPLoS One. 2012;7(3):e32635. *co-corresponding authors.

Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of FGF3 mutations associated with deafness and LAMM syndromeBMC Med Genet. 2011 Feb 9;12:21.

Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA, Hegde RS. The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cellsOncogene. 2010;29(25):3715-22.

Xi Z, Zhang Y, Hegde RS, Shakked Z, Crothers DM. Anomalous DNA binding by E2 regulatory protein driven by spacer sequence TATANucleic Acids Res. 2010 Jun;38(11):3827-33.

Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosisOncogene. 2010 Jan 21;29(3):368-79.

Trompette A, Divanovic S, Visintin A, Madan R, Blanchard C, Hegde RS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allergenicity resulting from functional mimicry of a Toll-like receptor complex proteinNature. 2009 Jan 29;457(7229):585-588.