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Biographies

Find another Doctor or Researcher

High Res

Robert Bruce Hinton, MD

Director, Heart Institute BioRepository (HIBR)

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-0389

Fax: 513-636-5958

Email: robert.hinton@cchmc.org

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Specialties

Clinical Interests

Cardiovascular genetics; echocardiography

Research Interests

Valve and aorta disease using human genetics and molecular developmental biology approaches

Biography

Dr. Hinton graduated from Bucknell University with degrees in Art History and Philosophy. He earned his medical degree from the Medical University of South Carolina in Charleston SC. He completed his pediatric residency training at Memorial Health University Medical Center in Savannah GA and his pediatric cardiology fellowship at Cincinnati Children’s Hospital Medical Center. Dr. Hinton went on to pursue a postdoctoral fellowship in Cardiovascular Genetics and Molecular Cardiology at Cincinnati Children’s. He has been an attending staff member of the Division of Cardiology since 2006.

Dr. Hinton’s clinical interests relate to cardiovascular genetics and echocardiography. He is a member of the cardiovascular genetics service, and staffs the echocardiography laboratory. Dr. Hinton’s academic interests focus on translational research efforts using mouse models of human disease to identify new therapeutic targets. Dr. Hinton is a member of the American Academy of Pediatrics, the American Heart Association, the American Society of Bioethics and Humanities, and the American Society of Matrix Biology. He was elected to the Society for Pediatric Research in 2007.

Education and Training

BA: Bucknell University, Lewisburg, PA.

MD: Medical University of South Carolina, Charleston, SC.

Residency: Memorial Health University Medical Center, Savannah, GA.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Fellowship: Cincinnati Children's Research Foundation, Cincinnati, OH.

Certification: Pediatrics, Pediatric Cardiology.

Publications

View PubMed Publications

Krishnamurthy VK, Guliak F, Narmoneva DA, Hinton RB. Regional structure-function relationships in mouse aortic valve tissue. J Biomech. Jan 2011;44(1):77-83.

Wirrig EE, Hinton RB, Yutzey KE. Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol. Mar 2011;50(3):561-569.

Calloway TJ, Martin LJ, Zhang X, Tandon A, Benson DW, Hinton RB. Risk factors for aortic valve disease in bicuspid aortic valve: a family-based study. Am J Med Genet A. May 2011;155A(5):1015-1020.

Hinton RB, Yutzey KE. Heart valve structure and function in development and disease. Annu Reb Physiol. Mar 2011;73:29-46.

Martin LJ, Hinton RB, Zhang X, Cripe LH, Benson DW. Aorta measurements are heritable and influenced by bicuspid aortic valve. Frontiers in Genetics. 2011;2(61).

Hinton RB. Genetic contribution to bicuspid aortic valve morphology. Am J Med Genet. 2011;155(11):2899-2900.

Acharya A, Hans CP, Koenig SN, Nichols HA, Galindo CL, Garner HR, Merrill WH, Hinton RB, Garg V. Inhibitory role of Notch1 in calcific aortic valve disease. PLoS One. 2011;6(11):e27743.

Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram D, Menick D, Field LJ, Firulli AB, Molkentin JD, Markwald RR, Conway SJ. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. Apr 2008;102(7):752-760.

Hinton RB, Alfieri C, Witt S, Glascock B, Khoury PR, Benson DW, Yutzey KE. Mouse heart valve structure and function: echocardiographic and morphometric analyses from the fetus through the aged adult. Am J Physio Heart Circ Physiol. 2008;294(6):H2480-2488.

Hinton RB, Andelfinger G, Sekar P, Hinton AC, Gendron RL, Michelfelder EC, Robitaille Y, Benson DW. Prenatal head growth and white matter injury in hypoplastic left heart syndrome. Pediatr Res. Oct 2008;64(4):364-369.

Grants

Angiogenesis Inhibition Therapy for Aortic Valve Disease. Principal Investigator. National Center for Research Resources (NIH/NCRR). Jul 2011-Jun 2012.

Twist1 regulation of valve progenitors. Co-Investigator. National Heart, Lung and Blood Institute (NIH/NHLBI). Jul 2010-Jun 2015.

Trial of Beta Blocker Therapy (Atenolol) vs. Angiotensis II Receptor Blocker Therapy (Losartan). Co-Investigator. National Heart, Lung and Blood Institute (NIH/NHLBI) Pediatric Heart Network. Sept 2006-Aug 2016.

Aortic root structure-function relationships in a mouse model of aortic valve disease and aortopathy. Supervisor. American Heart Association, Great Rivers Affiliate. Jul 2011-Jun 2012.