Biographies

E-mail this page

(All fields required)

Recipient's email address

Please enter a valid email.

Your name

Please enter your name.

Your email address

Please enter a valid email.

Find another Doctor or Researcher

High Res

Stacey S. Huppert, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-803-3871

Email: stacey.huppert@cchmc.org

Show All

Specialties

Hepatic development and regeneration; three-dimensional hepatic architecture; Notch signaling; hepatobiliary disease

Visit the Huppert Lab

Education and Training

BS: Genetic Biology,Purdue University, West Lafayette, IN, 1992.

PhD: Genetics, Indiana University, Bloomington, IN, 1998.

Postdoctoral Fellow: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2003.

Instructor: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2005.

Assistant Professor: Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, 2012.

Publications

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorg Med Chem. 2012 Mar 15;20(6):1869-77.

Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology. 2012 Jan;55(1):233-43.

Huppert SS. A new set of classifications for ductal plate malformations. Hepatology. 2011 Jun;53(6):1795-7.

Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech. 2011 May;4(3):359-67.

Sparks EE, Huppert KA, Brown MA, Washington MK, Huppert SS. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology. 2010 Apr;51(4):1391-400.

Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell. 2005 May;8(5):677-88.

Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000 Jun 22;405(6789):966-70. Erratum in: Nature. 2000 Nov 30;408(6812):616.

Huppert SS, Jacobsen TL, Muskavitch MA. Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development. 1997 Sep;124(17):3283-91.

Grants

Molecular requirements for proliferation of fetal and adult liver progenitors. Principal Investigator. National Institute of Health. July 2008 – June 2013. R01 DK078640.