Xiaonan Han, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-636-7592

Fax 513-636-5581

Email xiaonan.han@cchmc.org

Signal transducer and activator of transcription (STAT) in inflammatory bowel disease (IBD); gut barrier dysfunction in IBD; drug development in the therapy of IBD.

Visit the Han Lab web site.

PhD: Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), Beijing, China, 2000.

Post-doctoral: University of Pittsburgh Medical School, Pittsburgh, PA, 2003.

Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010 Aug;59(8):1066-78.

Munitz A, Cole ET, Beichler A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology. 2010 Aug;139(2):530-41.

Han X. Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies. Recent Pat Inflamm Allergy Drug Discov. 2010;4(2):159-76. Review.

Groschwitz KR, Ahrens R, Osterfeld H, Gurish MF, Han X, Abrink M, Finkelman FD, Pejler G, Hogan SP. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22381-6.

Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.

Han X, Ren X, Jurickova I, Groschwitz K, Pasternak BA, Xu H, Wilson TA, Hogan SP, Denson LA. Regulation of intestinal barrier function by signal transducer and activator of transcription 5b. Gut. 2009 Jan;58(1):49-58.

Carey R, Jurickova I, Ballard E, Bonkowski E, Han X, Xu H, Denson LA. Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel diseaseInflamm Bowel Dis. 2008 Apr;14(4):446-57.

Han X, Osuntokun B, Benight N, Loesch K, Frank SJ, Denson LA. Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis. Am J Pathol. 2006 Dec;169(6):1999-2013.

Han X, Benight N, Osuntokun B, Loesch K, Frank SJ, Denson LA. Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis. Gut. 2007 Jan;56(1):73-81.