Sickle cell disease and other hemoglobinopathies; red blood cell physiology; cation transport and volume regulation; hematological problems of the newborn

MD: Duke University School of Medicine, Durham, NC, 1977.

PhD: Physiology and Pharmacology, Duke University Durham, NC, 1977.

Residency: Duke University Medical Center, Durham, NC, 1978-1980.

Fellowship: Children's Hospital, Harvard Medical School, Boston, MA, 1980-1982.

Certification: General Pediatrics, American Academy of Pediatrics, 1983, sub-board in Neonatal/Perinatal Medicine, American Academy of Pediatrics, 1983.

Hammill AM, Risinger MA, Joiner CH, Keddache M, Kalfa TA. Compound heterozygosity for two novel mutations in the erythrocyte protein 4.2 gene causing spherocytosis in a Caucasian patient. Br J Haematol. 2011 Jan 31.

Yang MQ, Laflamme K, Gotea V, Joiner CH, Seidel NE, Wong C, Petrykowska HM, Lichtenberg J, Lee S, Welch L, Gallagher PG, Bodine DM, Elnitski L. Genome-wide detection of a TFIID localization element from an initial human disease mutation.Nucleic Acids Res. 2010 Nov 11.

George A, Pushkaran S, Li L, An X, Zheng Y, Mohandas N, Joiner CH, Kalfa TA. Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood Cells Mol Dis. 2010 Jun 15;45(1):41-5.

Rayburg M, Kalinyak KA, Towbin AJ, Baker PB, Joiner CH. Fatal bone marrow embolism in a child with hemoglobin SE disease.Am J Hematol. 2010 Mar;85(3):182-4.

Barber LA, Palascak MB, Joiner CH, Franco RS. Aminophospholipid translocase and phospholipid scramblase activities in sickle erythrocyte subpopulations. Br J Haematol. 2009 Aug;146(4):447-55.

Cohen RM, Franco RS, Khera PK, Smith EP, Lindsell CJ, Ciraolo PJ, Palascak MB, Joiner CH. Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. Blood. 2008 Nov 15;112(10):4284-91.

Khera PK, Joiner CH, Carruthers A, Lindsell CJ, Smith EP, Franco RS, Holmes YR, Cohen RM. Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation.Diabetes. 2008 Sep;57(9):2445-52.

Joiner CH. Gardos pathway to sickle cell therapies? Blood. 2008 Apr 15;111(8):3918-9.

Lindsell CJ, Franco RS, Smith EP, Joiner CH, Cohen RM. A method for the continuous calculation of the age of labeled red blood cells.Am J Hematol. 2008 Jun;83(6):454-7. Erratum in: Am J Hematol. 2008 Jul;83(7):608.

Roszell NJ, Danton MJ, Jiang M, Witte D, Daugherty C, Grimes T, Girdler B, Anderson KP, Franco RS, Degen JL, Joiner CH. Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice.Am J Hematol. 2007 Dec;82(12):1044-8.