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Biographies

Find another Doctor or Researcher

A photo of Jeanne M. James.

High Res

Jeanne M. James, MD

Associate Professor, UC Department of Pediatrics | Director, Cardiology Fellowship Program | Director, Mouse Echocardiography Core

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-3151

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Specialties

Cardiovascular genetics, echocardiography, congenital heart disease, medical education, molecular cardiology, ventricular remodeling, cardiac hypertrophy.

Visit the James Lab.

Biography

Jeanne James, MD, is an Associate Professor of Pediatrics at University of Cincinnati College of Medicine and is currently the Director of the Cardiology Fellowship Training Program at Cincinnati Children's Hospital Medical Center.

A native of West Virginia, Dr. James earned her bachelor and medical degrees from West Virginia University in Morgantown, WV. She completed her pediatric residency and pediatric cardiology fellowship at Vanderbilt University Medical Center in Nashville, TN. Dr. James has been an attending staff member of the Division of Cardiology at Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine since 1995.

Dr. James' academic interests are in translational research on heart muscle disease, cardiovascular genetics and echocardiography. She has made numerous scholarly contributions to the field with publications describing both laboratory-based and clinical research. She serves as a grant reviewer for the American Heart Association and is a peer-reviewer for a number of scientific and medical journals.

Dr. James has established collaborative relationships with laboratory researchers at Cincinnati Children’s Hospital, the University of Cincinnati College of Medicine and investigators across the United States. As the Director of the Mouse Echocardiography Core, she uses non-invasive imaging to evaluate phenotypes of transgenic mice, including embryonic mice.

Dr. James serves as an attending physician in clinical echocardiography laboratory as well as the inpatient cardiology ward and consult team. Dr. James is a member of the Cardiovascular Genetics (CVG) service and has significant responsibilities in the CVG outpatient clinic. Dr. James is a member of the American Society of Echocardiography, the American Heart Association and the Society for Pediatric Research.

Education and Training

MD: West Virginia University, Morgantown, WV, 1987.

Residency: Vanderbilt University Medical Center, Nashville, TN, 1987-90.

Fellowship: Vanderbilt University Medical Center, Nashville, TN, 1991-94.

Certification: Pediatrics, 1990 - present

Certified: Pediatric Cardiology, 1996 - present

Publications

View PubMed Publications

Pattison J, Waggoner J, James J, Martin L, Gulick J, Osinska H, Klevitsky R, Kranias E, Robbins J. (2008) Phospholamban overexpression in transgenic rabbits.Transgenic Research 17(2):157-70.

Suzuki T, Palmer B, James J, Wang Y, Chen V, VanBuren P, Maughan D, Robbins J, LeWinter M. (2009) Effects of cardiac myosin isoform variation on myofilament function and cross-bridge kinetics in transgenic rabbits.Circ Heart Fail 2(4):334-41.

James J, Hor K, Moga M, Martin L, Robbins J. (2010) Effects of myosin heavy chain manipulation in experimental heart failure.J Mol Cell Cardiol 48(5):999-1006.

Hinton R, Adelman-Brown J, Witt S, Krishnamurthy V, Gruber M, Osinska H, Sakthivel B, James J, Narmoneva D, Mecham R, Benson D. (2010) Elastin haploinsufficiency results in latent progressive aortic valve disease in a mouse model.Circ Res 107(4):549-57.

Acehan D, Vaz F, Houtkooper R, James J, Moore V, Tokunaga C, Kulik W, Wansapura J, Toth M, Strauss A and Khuchua Z. (2010) Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome.J Biol Chem 286(2):899-908.

Stanley BA, Graham DR, James J, Mitsak M, Tarwater PM, Robbins J, Van Eyk JE. (2011) Altered myofilament stoichiometry in response to heart failure in a cardioprotective a-myosin heavy chain transgenic rabbit model.Proteomics Clin Appl 5(3-4):147-58.

James J and Robbins J. (2011) Signaling and myosin binding protein C.J Biol Chem 286(12):9913-9.

Combs M, Braitsch C, Lange A, James J and Yutzey K. (2011) NFATc1 promotes epicardium-derived cell (EPDC) invasion into myocardium.Development 138(9):1747-57.

James J, Kinnett K, Ittenbach R, Wang Y, Benson D and Cripe L. (2011) Electrocardiographic abnormalities in very young Duchenne muscular dystrophy patients precede the onset of cardiac dysfunction. Neuromuscul Disord 21(7):462-7.

Sadayappan S, Gulick J, Martin L, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko V, Lorenz J, Maillet M, Martin J, Heller-Brown J, Bers D, Molkentin J, James J and Robbins J. (2011) A critical function for Ser-282 in cardiac myosin binding protein-C phosphorylation and cardiac function.Circ Res 109(2):141-50.

Cheek J, Wirrig E, Alfieri C, James J and Yutzey K. Differential activation of valvulogenic, chondrogenic and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease. In press.

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